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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Sapitinib||AZD8931|AZD-8931||EGFR Inhibitor (Pan) 55 HER2 Inhibitor 36 HER3 Inhibitor 1||Sapitinib (AZD-8931) binds to and inhibits the ERBB family members EGFR, ERBB2 (HER2), and ERBB3, which may lead to decreased tumor cell proliferation and increased apoptosis (PMID: 20145185, PMID: 31765988).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|BRAF L597Q||colon adenocarcinoma||predicted - sensitive||Sapitinib||Preclinical - Patient cell culture||Actionable||In a preclinical study, Sapitinib (AZD8931) inhibited growth of tumor cells derived from the metachronous para-aortal lymph node metastasis harboring BRAF L597Q, which was resected from a patient with colon adenocarcinoma (PMID: 31704811).||31704811|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|