Therapy Detail

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Therapy Name Saracatinib
Synonyms
Therapy Description

Saracatinib (AZD0530) is a multi-kinase inhibitor with activity against ABL and SRC, which may block proliferation, metastasis, and survival in cancer cells (PMID: 19393585).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Saracatinib AZD0530 BCR-ABL Inhibitor 25 SRC Inhibitor 29 Saracatinib (AZD0530) is a multi-kinase inhibitor with activity against ABL and SRC, which may block proliferation, metastasis, and survival in cancer cells (PMID: 19393585, PMID: 32398945).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132C intrahepatic cholangiocarcinoma sensitive Saracatinib Preclinical Actionable In a preclinical study, intrahepatic cholangiocarcinoma cells harboring IDH1 R132C demonstrated increased sensitivity to Saracatinib (AZD0530) induced growth inhibition compared to IDH1 wild-type cells in culture (PMID: 27231123). 27231123
Unknown unknown stomach cancer not applicable Saracatinib Phase II Actionable In a Phase II trial, Saracatinib (AZD0530) treatment resulted in stable disease in 23.5% (4/17) of patients with gastric cancer (PMID: 21400081). 21400081
BRAF V600E melanoma sensitive Saracatinib Preclinical Actionable In a preclinical study, saracatinib inhibited proliferation of human melanoma cell lines harboring BRAF V600E that are resistant to Braf inhibition in culture (PMID: 23242808). 23242808
IDH1 R132S intrahepatic cholangiocarcinoma sensitive Saracatinib Preclinical Actionable In a preclinical study, intrahepatic cholangiocarcinoma cells harboring IDH1 R132S demonstrated increased sensitivity to Saracatinib (AZD0530) induced growth inhibition compared to IDH1 wild-type cells in culture (PMID: 27231123). 27231123
ALK C1156Y ALK rearrange lung adenocarcinoma sensitive Saracatinib Preclinical - Patient cell culture Actionable In a preclinical study, Saracatinib (AZD0530) and Lorbrena (lorlatinib) synergistically inhibited viability of cells derived from the tumor from a patient with lung adenocarcinoma harboring ALK rearrangement and an acquired ALK C1156Y in culture (PMID: 31585938). 31585938
Unknown unknown osteosarcoma no benefit Saracatinib Phase II Actionable In a Phase II trial, Saracatinib (AZD0530) treatment was well tolerated, but did not result in statistically significant benefit in median progression-free survival (19.4 vs 8.6 months, p=0.47) or overall survival (not reached in both arms) compared to placebo in patients with osteosarcoma with lung metastases (PMID: 32398945; NCT00752206). 32398945

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Clinical Trial Phase Therapies Title Recruitment Status
NCT01216176 Phase Ib/II Anastrozole Saracatinib A Pharmacokinetic and Randomized Trial of Neoadjuvant Treatment With Anastrozole Plus AZDO530 in Postmenopausal Patients With Hormone Receptor Positive Breast Cancer Completed


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