Therapy Detail
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| Therapy Name | Bintrafusp alfa + NHS-IL12 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bintrafusp alfa | MSB0011359C|M7824 | Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117 TGFBR2 Antibody 3 | Bintrafusp alfa is a human PD-L1 (CD274) antibody fused with transforming growth factor-beta (TGF-beta, TGFBR2) receptor II extracellular domain, which blocks two immuno-inhibitory pathways simultaneously, therefore enhances anti-tumor immunity (PMID: 29298798, PMID: 32461347). | |
| NHS-IL12 | M9241|M-9241 | NHS-IL12 (M9241) is an immunocytokine composed of IL-12 linked to human tumor necrosis factor targeted IgG1, which may result in enhanced anti-tumor immune response (PMID: 24681847). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04235777 | Phase I | Bintrafusp alfa + NHS-IL12 | TGF-beta Trap (M7824) and NHS-IL12 (M9241) Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies | Recruiting | USA | 0 |
| NCT04303117 | Phase Ib/II | NHS-IL12 Bintrafusp alfa + NHS-IL12 | NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma | Recruiting | USA | 0 |
| NCT04756505 | Phase I | Bintrafusp alfa + NHS-IL12 | Immunotherapy (NHS-IL12 & Bintrafusp Alfa) and Radiation Therapy for the Treatment of Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer, the REINA Trial | Withdrawn | 0 | |
| NCT04327986 | Phase Ib/II | Bintrafusp alfa + NHS-IL12 | Immune Checkpoint Inhibitor M7824 and the Immunocytokine M9241 in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Advanced Pancreas Cancer | Terminated | USA | 0 |
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