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|Therapy Name||Avelumab + DCC-3014|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Avelumab||Bavencio||MSB0010718C||Immune Checkpoint Inhibitor 94 PD-L1/PD-1 antibody 66||Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov).|
|DCC-3014||DCC3014|DCC 3014||CSF1R Inhibitor 24||DCC-3014 inhibits CSF1R, potentially resulting in increased anti-tumor immune response in combination with other agents (Cancer Res 2016;76(14 Suppl):Abstract nr 4889, PMID: 29679908).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT04242238||Phase I||Avelumab + DCC-3014||Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas||Recruiting|