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Therapy Name TAK-169
Synonyms
Therapy Description

TAK-169 is an engineered toxin body comprising a fragment of CD38 antibody fused to Shiga-like toxin A-subunit (SLTA) that inactivates ribosomes, which potentially inhibits protein synthesis leading to killing of CD38-expressing cancer cells and tumor regression (Cancer Res 2019;79(13 Suppl):Abstract nr 2384).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TAK-169 TAK169|TAK 169 CD38 Antibody 17 TAK-169 is an engineered toxin body comprising a fragment of CD38 antibody fused to Shiga-like toxin A-subunit (SLTA) that inactivates ribosomes, which potentially inhibits protein synthesis leading to killing of CD38-expressing cancer cells and tumor regression (Cancer Res 2019;79(13 Suppl):Abstract nr 2384).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04017130 Phase I TAK-169 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Efficacy of TAK-169 in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Recruiting USA 0


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