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Therapy Name 7-hydroxystaurosporine
Synonyms
Therapy Description

7-hydroxystaurosporine (UCN-01) is a derivative of staurosporine that inhibits CHK1 and PKC, with higher potency toward PKC-alpha, PKC-beta, and PKC-gamma, and also modulates CDK activity through upregulation of CDK inhibitors, potentially resulting in inhibition of tumor growth (PMID: 8022414, PMID: 15831461, PMID: 15150122, PMID: 31942030).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
7-hydroxystaurosporine UCN-01|KRX-0601|NSC-638850 CDK Inhibitor (Pan) 3 CHK1 Inhibitor 17 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 PKC Inhibitor (Pan) 11 7-hydroxystaurosporine (UCN-01) is a derivative of staurosporine that inhibits CHK1 and PKC, with higher potency toward PKC-alpha, PKC-beta, and PKC-gamma, and also modulates CDK activity through upregulation of CDK inhibitors, potentially resulting in inhibition of tumor growth (PMID: 8022414, PMID: 15831461, PMID: 15150122, PMID: 31942030).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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