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|Therapy Name||9-ING-41 + Carboplatin + Paclitaxel|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|9-ING-41||9 ING 41||GSK-3beta Inhibitor 4||9-ING-41 is an ATP-competitive inhibitor that selectively blocks GSK-3beta, potentially leading to cell cycle arrest and apoptosis, and antitumor effects including inhibition of cell proliferation and tumor growth (PMID: 31894292, PMID: 29846250).|
|Carboplatin||Paraplatin||CBDCA||Chemotherapy - Platinum 6||Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary).|
|Paclitaxel||Taxol||7-Epipaclitaxel||Antimicrotubule Agent 12 BCL2 Family Inhibitor 6||Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03678883||Phase Ib/II||9-ING-41 + Carboplatin + Paclitaxel 9-ING-41 + Irinotecan 9-ING-41 + Doxorubicin 9-ING-41 + Lomustine 9-ING-41 + Carboplatin 9-ING-41 + Gemcitabine + Nab-paclitaxel 9-ING-41 9-ING-41 + Gemcitabine||9-ING-41 in Patients With Advanced Cancers||Recruiting|