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Vorolanib (X-82) is a dual VEGFR/PDGFR inhibitor, which inhibits tumor angiogenesis and cell proliferation in tumors (Journal of Clinical Oncology 34, no. 15_suppl (May 20 2016) 2588-2588).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Vorolanib||X-82|CM-082|CM082||PDGFR Inhibitor (Pan) 27 VEGFR Inhibitor (Pan) 32||Vorolanib (X-82) is a dual VEGFR/PDGFR inhibitor, which inhibits tumor angiogenesis and cell proliferation in tumors (PMID: 32335374, PMID: 30478190).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||Vorolanib||Phase I||Actionable||In a Phase I clinical trial, X-82 was tolerated and demonstrated preliminary efficacy in patients with advanced solid tumors (J Clin Oncol 30, 2012 (suppl; abstr 3041)).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT01296581||Phase I||Vorolanib||Safety Study of X-82 in Patients With Advanced Solid Tumors||Completed|