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|Therapy Name||CD45RA-depleted donor lymphocytes|
CD45RA-depleted donor lymphocytes are lymphocytes that have been treated to remove the CD45RA-expressing population, potentially resulting in decreased graft vs. host disease after transplantation (PMID: 25559618, PMID: 29500069).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CD45RA-depleted donor lymphocytes||CD45RA-depleted donor lymphocytes are lymphocytes that have been treated to remove the CD45RA-expressing population, potentially resulting in decreased graft vs. host disease after transplantation (PMID: 25559618, PMID: 29500069).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03849651||Phase II||TCR alpha/beta+/CD19+ depleted hematopoietic cells CD45RA-depleted donor lymphocytes anti-thymocyte globulin + Cyclophosphamide + Filgrastim + Fludarabine + Melphalan + Mesna + Thiotepa Blinatumomab||TCRalphabeta-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies||Recruiting||USA||0|
|NCT02960646||Phase I||Fludarabine + Melphalan CD45RA-depleted donor lymphocytes Cyclophosphamide Tacrolimus Rituximab||Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies||Completed||USA||0|