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Therapy Name ASLAN003
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ASLAN003 ASLAN 003|ASLAN-003 ASLAN003 inhibits dihydroorotate dehydrogenase, which may induce differentiation and inhibit proliferation of leukemia cells (PMID: 31699789).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown acute myeloid leukemia not applicable ASLAN003 Preclinical - Pdx & cell culture Actionable In a preclinical study, ASLAN003 induced differentiation and inhibited proliferation of acute myeloid leukemia (AML) cell lines and primary AML cells in culture, resulted in reduced tumor burden and prolonged survival in cell line xenograft and patient-derived xenograft (PDX) models (PMID: 31699789). 31699789

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03451084 Phase II ASLAN003 A Dose Optimisation Study of ASLAN003 in Acute Myeloid Leukemia Recruiting


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