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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|ASLAN003||ASLAN 003|ASLAN-003||ASLAN003 inhibits dihydroorotate dehydrogenase, which may induce differentiation and inhibit proliferation of leukemia cells (PMID: 31699789).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||acute myeloid leukemia||not applicable||ASLAN003||Preclinical - Pdx & cell culture||Actionable||In a preclinical study, ASLAN003 induced differentiation and inhibited proliferation of acute myeloid leukemia (AML) cell lines and primary AML cells in culture, resulted in reduced tumor burden and prolonged survival in cell line xenograft and patient-derived xenograft (PDX) models (PMID: 31699789).||31699789|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03451084||Phase II||ASLAN003||A Dose Optimisation Study of ASLAN003 in Acute Myeloid Leukemia||Recruiting|