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Therapy Name | B7-H3 CAR T cells |
Synonyms | |
Therapy Description |
B7-H3 CAR T cells are T-cells engineered to express a chimeric antigen receptor (CAR) that targets B7-H3, which potentially decrease growth of B7-H3-expressing tumor cells (PMID: 31485480). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
B7-H3 CAR T cells | SCRI-CARB7H3(s) | B7-H3 CAR T cells are T-cells engineered to express a chimeric antigen receptor (CAR) that targets B7-H3, which potentially decrease growth of B7-H3-expressing tumor cells (PMID: 31485480). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT04185038 | Phase I | B7-H3 CAR T cells | Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors | Recruiting | USA | 0 |
NCT05474378 | Phase I | B7-H3 CAR T cells | B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme | Recruiting | USA | 0 |