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Therapy Name Retroviral vector transduced B7-H3 CAR T cells
Synonyms
Therapy Description

Retroviral vector transduced B7-H3 CAR T cells are T cells engineered using a retroviral vector to express a chimeric antigen receptor (CAR) that targets B7-H3, which potentially decrease growth of B7-H3-expressing tumor cells (PMID: 31485480).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Retroviral vector transduced B7-H3 CAR T cells SCRI-CARB7H3(s) Retroviral vector transduced B7-H3 CAR T cells are T cells engineered using a retroviral vector to express a chimeric antigen receptor (CAR) that targets B7-H3, which potentially decrease growth of B7-H3-expressing tumor cells (PMID: 31485480).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04185038 Phase I Retroviral vector transduced B7-H3 CAR T cells Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors Recruiting USA 0
NCT05474378 Phase I Retroviral vector transduced B7-H3 CAR T cells B7-H3 Chimeric Antigen Receptor T Cells (B7-H3CART) in Recurrent Glioblastoma Multiforme Recruiting USA 0


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