Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|PRT543||PRT-543|PRT 543||PRMT5 Inhibitor 12||PRT543 is an inhibitor that selectively binds to and inhibits PRMT5, resulting in decreased histone H2A, H3, and H4 arginine mono and di-methylation, which potentially leads to modulation of gene expression resulting in decreased tumor cell growth (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03886831||Phase I||PRT543||A Study of PRT543 in Participants With Advanced Solid Tumors and Hematologic Malignancies||Active, not recruiting||USA||0|