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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AC480||BMS-599626|AC-480||EGFR Inhibitor (Pan) 46 HER2 Inhibitor 23||AC480 (BMS-599626) is an inhibitor of EGFR and ERBB2 (HER2), which may prevent downstream signaling and inhibit the proliferation of tumor cells that overexpress these receptors (PMID: 17062696, PMID: 30624604).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||AC480||Phase I||Actionable||In a Phase I trial, AC480 demonstrated safety and potential efficacy in patients with several solid tumor types (PMID: 21576284).||21576284|
|ERBB2 positive||Advanced Solid Tumor||predicted - sensitive||AC480||Phase I||Actionable||In a Phase I clinical trial, AC480 (BMS-599626) treatment demonstrated preliminary clinical activity, resulting in stable disease as best response in 25% (11/44) of patients with advanced solid tumors, including patients expressing EGFR and/or ERBB2, with 2 patients achieving stable disease for greater than 6 months (PMID: 21576284).||21576284|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|