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Therapy Name CAB-AXL-ADC
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CAB-AXL-ADC BA3011 CAB-AXL-ADC is an antibody-drug conjugate comprising a reversible Axl antibody conjugated to monomethyl auristatin E (MMAE), which delivers the cytotoxic agent to Axl-expressing tumor cells, potentially inducing cytotoxicity and tumor growth inhibition (Cancer Res 2018;78(13 Suppl):Abstract nr 827; Journal of Clinical Oncology 2018 36:15_suppl, TPS12126).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown pancreatic cancer not applicable CAB-AXL-ADC Preclinical - Pdx Actionable In a preclinical study, CAB-AXL-ADC treatment inhibited tumor growth in a prostate cancer cell line xenograft model and in Gemzar (gemcitabine)-resistant patient-derived xenograft (PDX) models of pancreatic cancer (Cancer Res 2018;78(13 Suppl):Abstract nr 827). detail...
Unknown unknown lung cancer not applicable CAB-AXL-ADC Preclinical - Cell line xenograft Actionable In a preclinical study, CAB-AXL-ADC treatment inhibited tumor growth in a lung cancer cell line xenograft model (Cancer Res 2018;78(13 Suppl):Abstract nr 827). detail...
Unknown unknown prostate cancer not applicable CAB-AXL-ADC Preclinical - Cell line xenograft Actionable In a preclinical study, CAB-AXL-ADC treatment inhibited tumor growth in a prostate cancer cell line xenograft model (Cancer Res 2018;78(13 Suppl):Abstract nr 827). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03425279 Phase Ib/II CAB-AXL-ADC CAB-AXL-ADC Safety and Efficacy Study in Patients With Solid Tumors Recruiting


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