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Therapy Name Mecbotamab Vedotin
Synonyms
Therapy Description

Mecbotamab Vedotin is an antibody-drug conjugate comprising a reversible Axl antibody conjugated to monomethyl auristatin E (MMAE), which delivers the cytotoxic agent to Axl-expressing tumor cells, potentially inducing cytotoxicity and tumor growth inhibition (Cancer Res 2018;78(13 Suppl):Abstract nr 827; Journal of Clinical Oncology 2018 36:15_suppl, TPS12126).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Mecbotamab Vedotin BA3011|CAB-AXL-ADC|BA-3011|BA 3011 AXL Antibody 5 Mecbotamab Vedotin is an antibody-drug conjugate comprising a reversible Axl antibody conjugated to monomethyl auristatin E (MMAE), which delivers the cytotoxic agent to Axl-expressing tumor cells, potentially inducing cytotoxicity and tumor growth inhibition (Cancer Res 2018;78(13 Suppl):Abstract nr 827; Journal of Clinical Oncology 2018 36:15_suppl, TPS12126).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03425279 Phase Ib/II Mecbotamab Vedotin CAB-AXL-ADC Safety and Efficacy Study in Patients With Solid Tumors Recruiting USA 2
NCT04681131 Phase II Mecbotamab Vedotin Mecbotamab Vedotin + unspecified PD-1 antibody CAB-AXL-ADC Safety and Efficacy Study in Adults With NSCLC Recruiting USA | ESP | DEU 4


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