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|Therapy Name||Cyclophosphamide + Oncolytic HSV-1 rRp450|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Cyclophosphamide||Cytoxan||CPM||Chemotherapy - Alkylating 16||Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).|
|Oncolytic HSV-1 rRp450||rRp450||Oncolytic HSV-1 rRp450 is an engineered oncolytic type-I herpes simplex virus 1 (HSV-1) that encodes CYP2B1, which activates cancer prodrugs including cyclophosphamide and enhances sensitivity to chemotherapy agents, potentially resulting in increased tumor cell lysis and reduced metastases (PMID: 12209705).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|