Therapy Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Therapy Name Tempol
Synonyms
Therapy Description

Tempol is a heterocyclic nitroxide free radical that induces cellular oxidative stress, and may inhibit the activity of Idh1 and Idh2, induce tumor cell death, and inhibit tumor cell proliferation (PMID: 32366855, PMID: 11033415).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
Tempol MTS-01|MBM-02|Piperidine Nitroxide Tempol is a heterocyclic nitroxide free radical that induces cellular oxidative stress, and may inhibit the activity of Idh1 and Idh2, induce tumor cell death, and inhibit tumor cell proliferation (PMID: 32366855, PMID: 11033415).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04874506 Phase II Tempol MBM-02 (Tempol) for the Treatment of Glioblastoma Multiforme (GBM) Unknown status USA 0
NCT04876755 Phase II Tempol MBM-02 (Tempol) for the Treatment of Biochemical Recurrent Prostate Cancer Unknown status USA 0
NCT04337099 Expanded access Tempol A Single Patient Compassionate Use of MBM-02 (Tempol) for the Treatment of Prostate Cancer Available USA 0
NCT05491928 Expanded access Tempol Treatment of Metastatic Cancer in Terminally Diagnosed Patients Available USA 0


Additional content available in CKB BOOST