Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Therapy Name | Anti-HER2/HER3 DC vaccine + Celecoxib + Interferon alpha-2b + Rintatolimod |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Anti-HER2/HER3 DC vaccine | Anti-HER2/3 dendritic cell vaccine | Anti-HER2/HER3 DC vaccine is a dendritic cell vaccine that targets ERBB2 (HER2) and HER3, which potentially stimulates cytotoxic immune response against tumor cells expressing ERBB2 (HER2) and HER3, and may reduce tumor growth (NCI Drug Dictionary). | ||
Celecoxib | Celebra | Celebra (celecoxib) is a COX-2 inhibitor FDA approved as an anti-inflammatory agent and for colorectal polyp reduction (FDA.gov) and also promotes apoptosis of tumor cells (PMID: 17909047). | ||
Interferon alpha-2b | Intron A | Alfatronol|Alfatronol|interferon alpha-2b|Sch 30500 | ||
Rintatolimod | Ampligen|Atvogen|Poly(I).Poly(c12,U) | Rintatolimod (Ampligen) is a synthetic dsRNA molecule that activates TLR3 and other interferon-induced proteins, which may result in increased anti-tumor immune response (PMID: 27045557, PMID: 19200817). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT04348747 | Phase II | Anti-HER2/HER3 DC vaccine + Celecoxib + Interferon alpha-2b + Pembrolizumab + Rintatolimod Anti-HER2/HER3 DC vaccine + Celecoxib + Interferon alpha-2b + Rintatolimod | Dendritic Cell Vaccines Against Her2/Her3, Cytokine Modulation Regimen, and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer | Not yet recruiting | USA | 0 |