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|Therapy Name||MSC2490484A + unspecified PD-L1 antibody|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MSC2490484A||M3814|M-3814|Nedisertib|Peposertib||DNA_PK Inhibitor 6||Peposertib (MSC2490484A) is a DNA-dependent protein kinase (DNA-PK) inhibitor that blocks DNA damage repair, which may lead to antitumor activity by sensitizing cancer cells to radiation and agents that induce DNA double strand breaks (PMID: 32220971).|
|unspecified PD-L1 antibody||Experimental PD-L1 antibody||PD-L1/PD-1 antibody 63|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||colorectal cancer||not applicable||MSC2490484A + unspecified PD-L1 antibody||Preclinical||Actionable||In a preclinical study, the combination of MSC2490484A and an unspecified PD-L1 antibody resulted in greater inhibition of tumor growth compared to the unspecified PD-L1 antibody alone in a colorectal cancer cell line mouse model (PMID: 32238472).||32238472|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|