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Therapy Name VLX600
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
VLX600 VLX-600|VLX 600 VLX600 is a small molecule drug that inhibits mitochondrial oxidative phosphorylation, which impairs mitochondrial function and induces autophagy, potentially increasing cell death, and inhibiting proliferation, and tumor growth (PMID: 24548894).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown colorectal cancer not applicable VLX600 Preclinical - Patient cell culture Actionable In a preclinical study, VLX600 treatment inhibited proliferation of cells derived from colorectal cancer patients in culture (PMID: 24548894). 24548894
Unknown unknown colon carcinoma not applicable VLX600 Preclinical - Cell line xenograft Actionable In a preclinical study, VLX600 treatment induced mitochondrial dysfunction, led to autophagy induced cell death, reduced clonogenicity and viability of quiescent cells in a spheroid culture, and inhibited proliferation of colon carcinoma cells in culture, and inhibited tumor growth in cell line xenograft models (PMID: 24548894). 24548894
Unknown unknown melanoma not applicable VLX600 Preclinical - Cell culture Actionable In a preclinical study, VLX600 treatment inhibited proliferation of a mouse melanoma cell line in culture (PMID: 24548894). 24548894
Unknown unknown breast carcinoma not applicable VLX600 Preclinical - Cell culture Actionable In a preclinical study, VLX600 treatment inhibited proliferation of a mouse breast carcinoma cell line in culture (PMID: 24548894). 24548894

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status


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