The Clinical Knowledgebase (CKB)

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CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. CKB CORE contains all the content associated with 50 genes that are commonly found on cancer hotspot panels. New and updated content is pushed out daily and viewable genes are available on a quarterly rotating schedule.

Check out   CKB BOOST for content extending to 1800+ genes.

Jul 18, 2022 - Time for the next quarterly update to the CORE gene list! We are highlighting the tyrosine kinase genes this quarter. If you have any questions/comments, please feel free to reach out to us at!

Apr 7, 2022 - Did you know you can find content related to TMB (tumor mutational burden), MSI (microsatellite instability), TILs (tumor infiltrating lymphocytes), and HRD (homologous repair deficiency) in CKB BOOST? Each biomarker can be found using 'Explore by Gene' or 'Explore by Variant'! Have questions or comments? Feel free to e-mail us at

Mar 18, 2022 - CKB BOOST update! You can now find clinical trials for select countries other than the US and Canada. The list currently includes France, Germany, Spain, Italy, Austria, and Belgium. Have questions or comments on how to best search for clinical trials? Email us at!