The Clinical Knowledgebase (CKB)

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CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. CKB CORE contains all the content associated with 85 genes that are commonly found on cancer hotspot panels. New and updated content is pushed out daily and viewable genes are available on a quarterly rotating schedule.

Not finding the content you need? Need more advanced searching?

Check out the CKB BOOST subscription version for content extending to 1,300+ genes.


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Request curation for specific Genes, variants, or PubMed publications.

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Feb 25, 2020 - The JAX-CKB team is looking for a Variant Assay Interpretation Scientist! More details regarding this exciting position can be found here.

Feb 12, 2020 - Check out this recent article to learn how CKB can be your genomic digital encyclopedia of cancer! Mainstreaming Precision Oncology

Jan 30, 2020 - We're looking for new people to join the JAX-CKB team! Check out the job listings here: Scientific Software Engineer

Jan 6, 2020 - CKB CORE now offers content for RSPO3, POLE, FANCA, and DOT1L, but removes EGFR, PTEN, TP53, and MET. However, these genes are always accessible with a CKB BOOST subscription!