The Clinical Knowledgebase (CKB)

Powered by The Jackson Laboratory

CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. CKB CORE contains all the content associated with 50 genes that are commonly found on cancer hotspot panels. New and updated content is pushed out daily and viewable genes are available on a quarterly rotating schedule.

Check out   CKB BOOST for content extending to 1800+ genes.

Oct 20, 2022 - Attention CKB users! We've made changes to improve the search performance and enhance the search results for Explore by Variant, providing you quick access to more variant-related content! If you have any questions or comments, please feel free to reach out to us at

Oct 17, 2022 - Time for the next quarterly update to the CORE gene list! We are highlighting the tumor suppressor genes this quarter. If you have any questions/comments, please feel free to reach out to us at!

Oct 14, 2022 - Looking for guidance on how to find the best interpretation tools for your oncology data? Then check out this recent commentary in BioIT World!

Sep 12, 2022 - Hello CKB users! Are you presenting a talk or poster at AMP 2022 that mentions CKB as a resource? If so, let us know! We would love to connect with you and promote your talk or poster at our JAX-CKB BOOTH #940! Feel free to e-mail us at