The Clinical Knowledgebase (CKB)

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CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. CKB CORE contains all the content associated with 85 genes that are commonly found on cancer hotspot panels. New and updated content is pushed out daily and viewable genes are available on a quarterly rotating schedule.

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Check out the CKB BOOST subscription version for content extending to 1,300+ genes.


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Jul 31, 2020 - New FDA approval for Atezolizumab plus Cobimetinib and Vemurafenib for patients with BRAF V600-positive advanced melanoma! Find more information on this in CKB CORE. Need up-to-date information on other FDA drug approvals? Consider a CKB BOOST subscription, which includes full acess to all drugs and their FDA approvals, along with related content!

May 11, 2020 - Check out CKB's new cancer variant visual navigation! Learn more here.

Jan 6, 2020 - CKB CORE now offers content for RSPO3, POLE, FANCA, and DOT1L, but removes EGFR, PTEN, TP53, and MET. However, these genes are always accessible with a CKB BOOST subscription!