The Clinical Knowledgebase (CKB)

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CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the same public access version we have been providing to the community since 2016. CKB CORE contains all the content associated with 86 genes that are commonly found on cancer hotspot panels. New and updated content is pushed out daily.

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Check out the CKB BOOST subscription version for content extending to 1,000+ genes.

Nov 27, 2018 - Vitrakvi (larotrectinib) approved regardless of tumor type for NTRK fusions, except with acquired resistance mutations! Need a list of resistance mutations? Visit and sign-up for CKB BOOST.