About CKB

The Jackson Laboratory Clinical Knowledgebase (CKB) is a semi-automated/manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and clinical trials related to oncology. CKB not only contains current information on the protein effect of somatic gene variants, but also connects the variant to targeted therapies through an efficacy evidence annotation. In addition, CKB captures clinical trial patient eligibility criteria that include genomic alterations (genotype-specific). The public access version of CKB encompasses 82 commonly known driver genes. Users can search CKB via gene, gene variants, drug, drug class, indication, and clinical trials. The web-based version of CKB is designed to interrogate the knowledgebase for specific data attributes while also enabling a robust browse like feature when the desired content is unknown.

CKB Data Model Overview:

For additional information, please contact ckbsupport@jax.org

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Citations About:

Sara E. Patterson, Rangjiao Liu, Cara M. Statz, Daniel Durkin, Anuradha Lakshminarayana, and Susan M. Mockus. The Clinical Trial Landscape in Oncology and Connectivity of Somatic Mutational Profiles to Targeted Therapies. Human Genomics, 2016 Jan 16;10(1):4. (PMID: 26772741)

Citation Use Cases:

  • Susan M. Mockus, Sara E. Patterson, Cara Statz, Carol J. Bult, Gregory J. Tsongalis. Clinical Trials in Precision Oncology. Clinical Chemistry, 2016 Mar 62(3):442-8. (PMID: 26607725) Related podcast
  • J.L. Dillon, S.M. Mockus, G. Ananda, V. Spotlow, W.A. Wells, G.J. Tsongalis, and J.D. Marotti. Somatic Gene Mutation Analysis of Triple Negative Breast Cancers. The Breast, 2016 Jul 7. (PMID: 27397723)
  • C.M. Statz, S.E. Patterson, S.M. Mockus, mTOR Inhibitors in Castration-Resistant Prostate Cancer. Target Oncol., (2016), Aug 9 [Epub ahead of print]. (PMID: 27503005)
  • Kaisaki, Pamela J., Anthony Cutts, Niko Popitsch, Carme Camps, Melissa M. Pentony, Gareth Wilson, Suzanne Page, et al, Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis. PloS One 11, no. 9 (2016): e0162809. doi:10.1371/journal.pone.0162809. (PMID: 27626278)


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