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| NCT ID | NCT01763164 |
| Title | Study Comparing the Efficacy of MEK162 Versus Dacarbazine in Unresectable or Metastatic NRAS Mutation-positive Melanoma |
| Recruitment | Completed |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | Novartis|Novartis Pharmaceuticals |
| Indications | |
| Therapies | |
| Age Groups: | adult |
| Covered Countries | USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | United States | Details | |
| Highlands Oncology Group | Rogers | Arkansas | 72758 | United States | Details | |
| Florida Cancer Specialists | Altamonte Springs | Florida | 32701 | United States | Details | |
| Florida Cancer Specialists | Bonita Springs | Florida | 34135 | United States | Details | |
| Florida Cancer Specialists | Bradenton | Florida | 34209 | United States | Details | |
| Florida Cancer Specialists | Brandon | Florida | 33511 | United States | Details | |
| Florida Cancer Specialists | Cape Coral | Florida | 33914 | United States | Details | |
| Florida Cancer Specialists | Clearwater | Florida | 33756 | United States | Details | |
| Florida Cancer Specialists | Clearwater | Florida | 33761 | United States | Details | |
| Florida Cancer Specialists | Fort Myers | Florida | 33905 | United States | Details | |
| Florida Cancer Specialists | Fort Myers | Florida | 33908 | United States | Details | |
| Florida Cancer Specialists | Gainesville | Florida | 32605 | United States | Details | |
| Florida Cancer Specialists | Hudson | Florida | 34667 | United States | Details | |
| Florida Cancer Specialists | Inverness | Florida | 34453 | United States | Details | |
| Florida Cancer Specialists | Largo | Florida | 33770 | United States | Details | |
| Florida Cancer Specialists | Largo | Florida | 33777 | United States | Details | |
| Florida Cancer Specialists | Naples | Florida | 34102 | United States | Details | |
| Florida Cancer Specialists | Naples | Florida | 34119 | United States | Details | |
| Florida Cancer Specialists | New Port Richey | Florida | 34655 | United States | Details | |
| Florida Cancer Specialists | Orange City | Florida | 32763 | United States | Details | |
| Florida Cancer Specialists | Orlando | Florida | 32806 | United States | Details | |
| Florida Cancer Specialists | Port Charlotte | Florida | 33980 | United States | Details | |
| Florida Cancer Specialists | Saint Petersburg | Florida | 33705 | United States | Details | |
| Florida Cancer Specialists | Saint Petersburg | Florida | 33707 | United States | Details | |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | United States | Details | |
| Florida Cancer Specialists | Sarasota | Florida | 34236 | United States | Details | |
| Florida Cancer Specialists | Spring Hill | Florida | 34608 | United States | Details | |
| Florida Cancer Specialists | Tampa | Florida | 33607 | United States | Details | |
| Florida Cancer Specialists | Tampa | Florida | 33613 | United States | Details | |
| Florida Cancer Specialists | Tavares | Florida | 32778 | United States | Details | |
| Florida Cancer Specialists | Venice | Florida | 34285 | United States | Details | |
| Florida Cancer Specialists | Venice | Florida | 34292 | United States | Details | |
| Oncology Specialists, SC | Niles | Illinois | 60714 | United States | Details | |
| Oncology Specialists, SC | Park Ridge | Illinois | 60068 | United States | Details | |
| Goshen Center For Cancer Care | Goshen | Indiana | 46526 | United States | Details | |
| Eastern Maine Medical Center | Bangor | Maine | 04401 | United States | Details | |
| Harry and Jeannette Weinberg Cancer Institute @Franklin Square | Baltimore | Maryland | 21237 | United States | Details | |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | United States | Details | |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | United States | Details | |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | United States | Details | |
| Kresge Eye Institute | Bingham Farms | Michigan | 48025 | United States | Details | |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | United States | Details | |
| Kresge Eye Institute | Detroit | Michigan | 48201 | United States | Details | |
| Karmanos Cancer Institute of Farmington Hills | Farmington Hills | Michigan | 48334 | United States | Details | |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | United States | Details | |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | United States | Details | |
| Cooper University Hospital | Voorhees | New Jersey | 08043 | United States | Details | |
| The Ohio State University James Cancer Hospital | Columbus | Ohio | 43210 | United States | Details | |
| The Ohio State University Martha Morehouse Medical Plaza | Columbus | Ohio | 43221 | United States | Details | |
| OHSU Knight Cancer Institute | Portland | Oregon | 97201 | United States | Details | |
| Kaiser Permanente Northwest Region Oncology/Hematology | Portland | Oregon | 97227 | United States | Details | |
| OHSU Center for Health and Healing | Portland | Oregon | 97239 | United States | Details | |
| OHSU | Portland | Oregon | 97239 | United States | Details | |
| Oregon Health and Science University | Portland | Oregon | 97239 | United States | Details | |
| Cancer Center Associates - Medical Oncology | Allentown | Pennsylvania | 18104 | United States | Details | |
| St. Luke's Cancer Center - Allentown Campus | Allentown | Pennsylvania | 18104 | United States | Details | |
| St. Luke's Hospital - Allentown Campus | Allentown | Pennsylvania | 18104 | United States | Details | |
| Cancer Center Associates - Medical Oncology | Bethlehem | Pennsylvania | 18015 | United States | Details | |
| St. Luke's University Hospital - Bethlehem Campus | Bethlehem | Pennsylvania | 18015 | United States | Details | |
| St. Luke's Cancer Center - Anderson Campus | Easton | Pennsylvania | 18045 | United States | Details | |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | United States | Details | |
| Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| Thomas Jefferson Medical Oncology | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | United States | Details | |
| St. Luke's Hospital - Quakertown Campus | Quakertown | Pennsylvania | 18951 | United States | Details | |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | United States | Details | |
| Texas Oncology-Austin Central | Austin | Texas | 78731 | United States | Details | |
| Elliot J. Ginchansky, MD, PA | Dallas | Texas | 75230 | United States | Details | |
| Dennis B. Kay | Dallas | Texas | 75231 | United States | Details | |
| Parkland Memorial Hospital | Dallas | Texas | 75235 | United States | Details | |
| UT Southwestern University Hospital- St. Paul | Dallas | Texas | 75235 | United States | Details | |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | United States | Details | |
| UT Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | United States | Details | |
| UT Southwestern University Hospital - Zale Lipshy | Dallas | Texas | 75390 | United States | Details | |
| US Oncology | Fort Worth | Texas | 76177-3204 | United States | Details | |
| US Oncology | The Woodlands | Texas | 77380 | United States | Details | |
| Sanatorio de La Providencia | Buenos Aires | Ciudad Autónoma DE Buenosaires | C1050AAK | Argentina | Details | |
| Centro de Investigación Clínica ? Clínica Viedma | Viedma | RÍO Negro | 08500 | Argentina | Details | |
| Centro Oncologico de Rosario | Rosario | Santa FE | S2000KZE | Argentina | Details | |
| Fundacion CIDEA | Buenos Aires | C1125ABE | Argentina | Details | ||
| Chris O'Brien Lifehouse Hospital | Camperdown | New South Wales | 2050 | Australia | Details | |
| Lake Macquarie Private Hospital | Gateshead | New South Wales | 02290 | Australia | Details | |
| Melanoma Institute Australia | North Sydney | New South Wales | 2060 | Australia | Details | |
| Princess Alexandra Hospital | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Royal Adelaide Hospital | Adelaide | South Australia | 05000 | Australia | Details | |
| LKH-Universitätsklinikum Klinikum Graz | Graz | Steiermark | 08036 | Austria | Details | |
| Universitätsklinikum Innsbruck | Innsbruck | Tirol | 06020 | Austria | Details | |
| Salzburger Landeskliniken | Salzburg | 05020 | Austria | Details | ||
| Allgemeines Krankenhaus der Stadt Wien | Vienna | 01090 | Austria | Details | ||
| Sint-Augustinuskliniek | Wilrijk | Antwerpen | 2610 | Belgium | Details | |
| UZ Gasthuisberg | Leuven | 03000 | Belgium | Details | ||
| CHU Sart Tilman | Liege | 04000 | Belgium | Details | ||
| Hospital de Clinicas de Passo Fundo | Passo Fundo | RIO Grande DO SUL | 99010-260 | Brazil | Details | |
| Hospital Moinhos de Vento | Porto Alegre | RIO Grande DO SUL | 90035-903 | Brazil | Details | |
| Hospital Moinhos de Vento | Porto Alegre | RIO Grande DO SUL | 90560-030 | Brazil | Details | |
| INCA Instituto Nacional de Cancer | Rio de Janeiro | 20220410 | Brazil | Details | ||
| Hospital São José | Sao Paulo | 01321-001 | Brazil | Details | ||
| Alberta Health Services - Cross Cancer Institute | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| London Regional Cancer Program | London | Ontario | N6A 4L6 | Canada | Details | |
| Sunnybrook Research Institute Centre | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| McGill University Health Center / Royal Victoria Hospital | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| CHU de Quebec - L'Hotel-Dieu de Quebec | Quebec | G1R 2J6 | Canada | Details | ||
| Mou/Mmci - Ppds | Brno | Jihomoravský KRAJ | 656 53 | Czechia | Details | |
| Fakultni nemocnice Ostrava | Ostrava | 708 52 | Czechia | Details | ||
| Fakultni nemocnice Kralovske Vinohrady | Praha 10 | 100 34 | Czechia | Details | ||
| Vseobecna Fakultni Nemocnice V Praze | Praha 2 | 128 08 | Czechia | Details | ||
| CHU Angers | Angers | Maine-et-loire | 49033 | France | Details | |
| CHRU de Lille - Hôpital Huriet | Lille | Nord | 59037 | France | Details | |
| Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes | Lyon | Rhône | 69373 | France | Details | |
| Hôpital Saint-André | Bordeaux | 33000 | France | Details | ||
| Centre Hospitalier Universitaire Ambroise Pare | Boulogne Billancourt | 92100 | France | Details | ||
| Centre Hospitalier Le Mans | Le Mans | 72037 | France | Details | ||
| Hopitaux de La Timone | Marseille | 13385 | France | Details | ||
| Groupe Hospitalier Archet I Et II | Nice | 06202 | France | Details | ||
| Hôpital Saint Louis | Paris | 75010 | France | Details | ||
| Service de PneumologieCHU Lyon Sud | Pierre Benite | 69495 | France | Details | ||
| Hôpital Robert Debré | Reims | 51092 | France | Details | ||
| Centre Hospitalier Universitaire Hopitaux de Rouen | Rouen | 76031 | France | Details | ||
| Universitaetsklinikum Freiburg | Freiburg im Breisgau | Baden-württemberg | 79104 | Germany | Details | |
| Klinikum Mannheim Universitätsklinikum gGmbH | Mannheim | Baden-württemberg | 68135 | Germany | Details | |
| LMU Klinikum der Universität München | München | Bayern | 80337 | Germany | Details | |
| University Clinic Regensburg - PPDS | Regensburg | Bayern | 93053 | Germany | Details | |
| Universitätsklinikum Würzburg | Würzburg | Bayern | 97080 | Germany | Details | |
| Institut für Diagnostische und Interventionelle Radiologie Frankfurt | Frankfurt | Hessen | 60590 | Germany | Details | |
| Universitätsklinikum Frankfurt | Frankfurt | Hessen | 60590 | Germany | Details | |
| Elben Klinken Stade Buxtehude | Buxtehude | Niedersachsen | 21614 | Germany | Details | |
| Johannes Wesling Klinikum Minden | Minden | Nordrhein-westfalen | 32429 | Germany | Details | |
| Klinikum Dorothea Christiane Erxleben Quedlinburg GmbH | Quedlinburg | Sachsen-anhalt | 06484 | Germany | Details | |
| Universitatsklinikum Leipzig | Leipzig | Sachsen | 04103 | Germany | Details | |
| Charite Campus Mitte | Berlin | Schleswig-holstein | 10117 | Germany | Details | |
| Helios Klinikum Erfurt | Erfurt | Thüringen | 99089 | Germany | Details | |
| Universitätsklinikum Carl Gustav Carus an der TU Dresden | Dresden | 01307 | Germany | Details | ||
| Universitätsklinikum Essen | Essen | 45147 | Germany | Details | ||
| SRH Wald-Klinikum Gera GmbH | Gera | 07548 | Germany | Details | ||
| Medizinische Hochschule Hannover (Hannover Medical School) | Hannover | 30625 | Germany | Details | ||
| University Clinic Heidelberg - PPDS | Heidelberg | 69120 | Germany | Details | ||
| Universitatsklinikum Schleswig-Holstein | Kiel | 24105 | Germany | Details | ||
| Uniklinik Köln | Koeln | 50937 | Germany | Details | ||
| Universitatsklinikum Schleswig-Holstein | Lübeck | 23538 | Germany | Details | ||
| Fachklinik Hornheide | Münster | 48157 | Germany | Details | ||
| Klinikum Nuernberg Nord | Nürnberg | 90419 | Germany | Details | ||
| Universitätsklinikum Tübingen | Tübingen | 72076 | Germany | Details | ||
| Universit*ätsklinikum Ulm | Ulm | 89081 | Germany | Details | ||
| Laiko General Hospital of Athens | Athens | 115 27 | Greece | Details | ||
| Magyar Honvédség Egészségügyi Központ | Budapest | 01062 | Hungary | Details | ||
| Orszagos Onkologiai Intezet | Budapest | H-1122 | Hungary | Details | ||
| Somogy Megyei Kaposi Mór Oktató Kórház | Kaposvár | 07400 | Hungary | Details | ||
| Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet | Szolnok | 05004 | Hungary | Details | ||
| Rambam Medical Center - PPDS | Haifa | 3109601 | Israel | Details | ||
| Hadassah Medical Center - PPDS | Jerusalem | 91120 | Israel | Details | ||
| Sheba Medical Center - PPDS | Ramat Gan | 5262100 | Israel | Details | ||
| AOU dell'Università degli Studi della Campania Luigi Vanvitelli | Napoli | Campania | 80138 | Italy | Details | |
| Istituto Dermopatico dell'Immacolata IRCCS | Roma | Lazio | 00167 | Italy | Details | |
| ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia | Brescia | Lombardia | 25123 | Italy | Details | |
| Istituto Nazionale per lo studio e la cura dei tumori Fondazione Giovanni Pascale | Napoli | Naples | 80131 | Italy | Details | |
| Istituto Oncologico Veneto - I.R.C.C.S. | Padova | Veneto | 35128 | Italy | Details | |
| IRCCS Giovanni Paolo II Istituto Oncologico | Bari | 70126 | Italy | Details | ||
| ASST Papa Giovanni XXIII - Azienda Ospedaliera Papa Giovanni XXIII | Bergamo | 24129 | Italy | Details | ||
| IRCCS Az. Osp. Universitaria San Martino- IST | Genova | 16132 | Italy | Details | ||
| Ospedale San Raffaele S.r.l. - PPDS | Milano | 20132 | Italy | Details | ||
| Fondazione IRCCS 'Istituto Nazionale dei Tumori' di Milano | Milano | 20133 | Italy | Details | ||
| Istituto Nazionale Tumori Regina Elena | Roma | 00144 | Italy | Details | ||
| Azienza Ospedaliera Universitaria Senese | Siena | 53100 | Italy | Details | ||
| A.O.U. Città della Salute e della Scienza di Torino - Presidio S. Lazzaro | Torino | 10126 | Italy | Details | ||
| Shinshu University Hospital | Matsumoto | Nagano | 390-8621 | Japan | Details | |
| National Cancer Center Hospital | Chuo-ku | 1040045 | Japan | Details | ||
| Kansai Medical University Hospital | Hirakata-city | 573-1191 | Japan | Details | ||
| Asan Medical Center - PPDS | Seoul | 05505 | Korea, Republic of | Details | ||
| Samsung Medical Center - PPDS | Seoul | 06351 | Korea, Republic of | Details | ||
| Seoul National University Hospital | Seoul | 110-744 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System - PPDS | Seoul | 3722 | Korea, Republic of | Details | ||
| Radboud University Nijmegen Medical Centre | Nijmegen | Gelderland | 6525 GA | Netherlands | Details | |
| Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis | Amsterdam | Noord-holland | 1066 CX | Netherlands | Details | |
| Leids Universitair Medisch Centrum | Leiden | Zuid-holland | 2333ZA | Netherlands | Details | |
| Isala Klinieken | Zwolle | 8025 AB | Netherlands | Details | ||
| Centrum Medyczne MAVIT Sp. z o.o. | Warszawa | Mazowieckie | 01-673 | Poland | Details | |
| Lux Med | Warszawa | 02-676 | Poland | Details | ||
| Centrum Onkologii Instytut im. Marii Sklodowskiej-Curie | Warszawa | 02-781 | Poland | Details | ||
| Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E. | Lisbon | Lisboa | 1099-023 | Portugal | Details | |
| Hospital Garcia de Orta*E.P.E. | Almada | 2801-951 | Portugal | Details | ||
| Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria | Lisboa | 1649-035 | Portugal | Details | ||
| Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS | Porto | 4200-072 | Portugal | Details | ||
| Russian Oncology Research Center n a N N Blokhin | Moscow | 115478 | Russian Federation | Details | ||
| Ryazan Regional Clinical Oncology Dispensary | Ryazan | 390011 | Russian Federation | Details | ||
| Scientific Research Institute of Oncology n.a. N.N. Petrov | St. Petersburg | 197758 | Russian Federation | Details | ||
| Narodny onkologicky ustav | Bratislava | 833 01 | Slovakia | Details | ||
| University of The Free State | Bloemfontein | FREE State | 09301 | South Africa | Details | |
| Sandton Oncology Medical Group | Johannesburg | Gauteng | 02196 | South Africa | Details | |
| Sandton Oncology Medical Research | Johannesburg | Gauteng | 02199 | South Africa | Details | |
| Steve Biko Academic Hospital | Pretoria | Gauteng | 00002 | South Africa | Details | |
| Mary Potter Oncology Centre | Pretoria | Gauteng | 00027 | South Africa | Details | |
| ICO l'Hospitalet - Hospital Duran i Reynals | L'Hospitalet de Llobregat | Barcelona | 08907 | Spain | Details | |
| Hospital Regional Universitario de Malaga Hospital General | Malaga | Málaga | 29010 | Spain | Details | |
| Clinica Universidad Navarra | Pamplona | Navarra | 31008 | Spain | Details | |
| Hospital Universitario Vall d'Hebrón - PPDS | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona | Barcelona | 08036 | Spain | Details | ||
| ICO l'Hospitalet - Hospital Duran i Reynals | Barcelona | 08907 | Spain | Details | ||
| Complejo Hospitalario Universitario Insular - Materno Infantil | Gran Canaria | 35001 | Spain | Details | ||
| Hospital Universitario A Coruña | La Coruna | 15006 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon | Madrid | 28009 | Spain | Details | ||
| MD Anderson Cancer Center | Madrid | 28033 | Spain | Details | ||
| Hospital Universitario Fundacion Jimenez Diaz | Madrid | 28040 | Spain | Details | ||
| Hospital Universitario HM Sanchinarro - CIOCC | Madrid | 28050 | Spain | Details | ||
| Hospital Universitario Virgen Macarena | Sevilla | 41009 | Spain | Details | ||
| Hospital Virgen de La Salud | Toledo | 45004 | Spain | Details | ||
| Fundacion Instituto Valenciano de Oncologia | Valencia | 46009 | Spain | Details | ||
| Consorcio Hospital General Universitario de Valencia | Valencia | 46014 | Spain | Details | ||
| Skanes Universitetssjukhus Lund | Lund | Skane LAN | Sweden | Details | ||
| Skanes Universitetssjukhus Lund | Lund | 221 85 | Sweden | Details | ||
| Universitätsspital Zürich | Zurich | Zürich (DE) | 08091 | Switzerland | Details | |
| Hôpitaux Universitaires de Genève | Genève | 01211 | Switzerland | Details | ||
| Centre Hospitalier Universitaire Vaudois | Lausanne | 01011 | Switzerland | Details | ||
| Ege University Medical Faculty | Bornova | Izmir | 35100 | Turkey | Details | |
| Adana Ba?kent Hastanesi K??la Yerle?kesi | Adana | 01230 | Turkey | Details | ||
| Hacettepe University Medical Faculty | Ankara | 06100 | Turkey | Details | ||
| Baskent University Medical Faculty Ankara Hospital | Ankara | 06490 | Turkey | Details | ||
| Istanbul University Cerrahpasa Medical Faculty Hospital | Istanbul | 34098 | Turkey | Details | ||
| Bristol Haematology and Oncology Centre | Bristol | Bristol, CITY OF | BS2 8ED | United Kingdom | Details | |
| Royal Cornwall Hospital | Truro | Cornwall | TR1 3LJ | United Kingdom | Details | |
| The Royal Sussex County Hospital | Brighton | EAST Sussex | BN2 5BE | United Kingdom | Details | |
| Broomfield Hospital | Chelmsford | Essex | CM1 7ET | United Kingdom | Details | |
| Singleton Hospital - PPDS | Swansea | Glamorgan | SA2 8QA | United Kingdom | Details | |
| Royal Preston Hospital | Preston | Lancashire | PR2 9HT | United Kingdom | Details | |
| Royal Marsden Hospital - Surrey | London | London, CITY OF | SW3 6JJ | United Kingdom | Details | |
| Queen Elizabeth Hospital | Birmingham | B15 2TH | United Kingdom | Details | ||
| St James s Institute of Clinical Oncology | Leeds | LS9 7TF | United Kingdom | Details | ||
| Clatterbridge Hospital | Wirral | CH63 4JY | United Kingdom | Details |