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NCT ID NCT03274492
Title A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements Yes
Sponsors Hoffmann-La Roche
Indications

diffuse large B-cell lymphoma

B-cell lymphoma

Therapies

Polatuzumab vedotin-piiq

Cyclophosphamide + Doxorubicin + Prednisone + Rituximab

Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate

Age Groups: adult | senior
Covered Countries USA | ITA | FRA | ESP | DEU | CAN | BEL | AUT

Facility Status City State Zip Country Details
University of Alabama at Birmingham Birmingham Alabama 35294 United States Details
Southern Cancer Center Daphne Alabama 36526 United States Details
City of Hope Duarte California 91010 United States Details
Ronald Reagan UCLA Medical Center; Drug Information Center Los Angeles California 90095 United States Details
Georgetown University Medical Center Washington District of Columbia 20007 United States Details
Florida Cancer Specialists - Fort Myers (New Hampshire Ct) Fort Myers Florida 33901-8101 United States Details
Florida Cancer Specialists & Research Institute Saint Petersburg Florida 33705 United States Details
Florida Cancer Specialists West Palm Beach Florida 33401 United States Details
Emory University; Investigational Drug Service Atlanta Georgia 30322 United States Details
Illinois Cancer Specialists Arlington Heights Illinois 60005 United States Details
University of Louisville Hospital; The James Graham Brown Cancer Center Louisville Kentucky 40202 United States Details
Ochsner Medical Center New Orleans Louisiana 70121 United States Details
University of Maryland Baltimore Maryland 21201 United States Details
Johns Hopkins University Baltimore Maryland 21287 United States Details
Massachusetts General Hospital Boston Massachusetts 02114 United States Details
Dana Farber Cancer Institute; Lymphoma Program Boston Massachusetts 02115 United States Details
Beth Israel Deaconess Medical Center Boston Massachusetts 02215 United States Details
University of Michigan Health System; UMH Internal Medicine/Hematology-Oncology Ann Arbor Michigan 48109 United States Details
Karmanos Cancer Center Detroit Michigan 48201 United States Details
HCA Midwest Division Kansas City Missouri 64132 United States Details
Washington University; Wash Uni. Sch. Of Med Saint Louis Missouri 63110 United States Details
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 United States Details
Roswell Park Cancer Institute; Grace Cancer Drug Center Buffalo New York 14263 United States Details
Memorial Sloan Kettering Cancer Center - Commack Commack New York 11725 United States Details
Memorial Sloan Kettering Cancer Center at Westchester Harrison New York 10604 United States Details
New York University Cancer Cen New York New York 10016 United States Details
Memorial Sloan Kettering Cancer Center New York New York 10065 United States Details
University of Rochester Medical Center Rochester New York 14618 United States Details
University of North Carolina at Chapel Hill Chapel Hill North Carolina 27514 United States Details
Levine Cancer Institute - Clincal Trials Administration Charlotte North Carolina 28204 United States Details
University Hospitals Case Medical Center Cleveland Ohio 44106 United States Details
Ohio State University; B406 Starling-Loving Hall Columbus Ohio 43210 United States Details
Oncology/Hematology Care Clinical Trials LLC Fairfield Ohio 45014 United States Details
Oncology Associates of Oregon, P.C Eugene Oregon 97401 United States Details
Oregon HSU; Bld-Brain Barr/Neuro-Onc Portland Oregon 97239 United States Details
Northwest Cancer Specialists - Portland (SW Barnes Rd) Tigard Oregon 97223 United States Details
Hospital of the University of Pennsylvania Philadelphia Pennsylvania 19104 United States Details
Fox Chase Cancer Center; Hematology/Oncology Philadelphia Pennsylvania 19111 United States Details
University of Pittsburgh Medical Center Cancer Center; Pharmacy Pittsburgh Pennsylvania 15232 United States Details
Medical University of South Carolina Hospital Charleston South Carolina 29425 United States Details
Prisma Health - Upstate Greenville South Carolina 29615 United States Details
Tennessee Oncology - Chattanooga; Tennessee Oncology - East Third Street Chattanooga Tennessee 37404 United States Details
Sarah Cannon Research Institute Nashville Tennessee 37203 United States Details
Texas Oncology-Austin Midtown Austin Texas 78705 United States Details
Rocky Mountain Cancer Centers, LLP Irving Texas 75063 United States Details
Texas Oncology-Tyler Irving Texas 75063 United States Details
Texas Oncology San Antonio Medical Center San Antonio Texas 78240 United States Details
University of Utah; Huntsman Cancer Hospital Salt Lake City Utah 84112 United States Details
Oncology Associates of Southwest Virginia, Inc. Blacksburg Virginia 24060 United States Details
Virginia Cancer Specialists, PC Fairfax Virginia 22031 United States Details
Shenandoah Oncology Associates Winchester Virginia 22601 United States Details
Seattle Cancer Care Alliance; Investigational Drug Service Seattle Washington 98101 United States Details
North Star Lodge Yakima Washington 98902 United States Details
West Virginia Uni Med. Center - Robert Byrd Health Science Morgantown West Virginia 26506 United States Details
Concord Repatriation General Hospital Concord New South Wales 2139 Australia Details
St George Hospital Kogarah New South Wales 2217 Australia Details
Prince of Wales Hospital; Haematology Randwick New South Wales 2031 Australia Details
Calvary Mater Newcastle Waratah New South Wales 2298 Australia Details
Westmead Hospital; Outpatient Pharmacy University Clinic Westmead New South Wales 2145 Australia Details
Princess Alexandra Hospital Woolloongabba; Clinical Hematology and Medical Oncology Woolloongabba Queensland 4102 Australia Details
Ashford Cancer Center Research Kurralta Park South Australia 5037 Australia Details
The University of Adelaide - The Queen Elizabeth Hospital (TQEH) Woodville South South Australia 5011 Australia Details
Monash Medical Centre Clayton Victoria 3168 Australia Details
Austin Hospital; Cancer Clinical Trials Centre Melbourne Victoria 3084 Australia Details
Medizinische Universitaet Innsbruck - Universitaetsklinik fuer Innere Medizin III Innsbruck 6020 Austria Details
Landesklinikum Krems Krems 3500 Austria Details
Paracelsus Medizinischen Privatuniversitaet-Salzburger Landeskliniken (SALK) Salzburg 5020 Austria Details
Medizinische Universität Wien Wien 1090 Austria Details
Wiener Gesundheitsverbund - Klinik Ottakring Wien 1160 Austria Details
UZ Gent Gent 9000 Belgium Details
CH Jolimont - Lobbes (Jolimont) Haine-Saint-Paul 7100 Belgium Details
CHU UCL Mont-Godinne Mont-godinne 5530 Belgium Details
Hospital Erasto Gaertner Curitiba PR 81520-060 Brazil Details
Hospital Sao Vicente de Paulo Passo Fundo RS 99010-090 Brazil Details
Hospital das Clinicas - UFRGS Porto Alegre RS 90035-903 Brazil Details
Centro de Hematologia e Hemoterapia - HEMOCENTRO UNICAMP Campinas SP 13083-878 Brazil Details
Hospital das Clinicas - FMUSP Sao Paulo SP 05403-900 Brazil Details
University of Alberta Hospital Edmonton Alberta T6G 1Z2 Canada Details
BC Cancer - Vancouver Vancouver British Columbia V5Z 4E6 Canada Details
CancerCare Manitoba (CCMB) Winnipeg Manitoba MB R3E 0V9 Canada Details
McMaster University Medical Center, Juravinski Cancer Centre, Hamilton Health Sciences Hamilton Ontario L8V 5C2 Canada Details
The Ottawa Hospital Ottawa Ontario K1H 8L6 Canada Details
Sunnybrook Health Sciences Centre Toronto Ontario M4N 3M5 Canada Details
University Health Network; Princess Margaret Hospital; Medical Oncology Dept Toronto Ontario M5G 2M9 Canada Details
CIUSSS de l'Est-de-l'Ile-de-Montréal - Hôpital Maisonneuve-Rosemont Montreal Quebec H1T 2M4 Canada Details
Centre Hospitalier de l'Universite de Montreal - Pavillon E (PEA) Montreal Quebec H2X 1P1 Canada Details
CHU de Quebec-Universite Laval Quebec G1S 4L8 Canada Details
Peking Union Medical College Hospital Beijing City 100032 China Details
Beijing Cancer Hospital Beijing 100142 China Details
The First Hospital of Jilin University Changchun City 130021 China Details
Fujian Provincial Cancer Hospital Fuzhou City 350014 China Details
Sun Yet-sen University Cancer Center Guangzhou 510060 China Details
The First Affiliated Hospital of College of Medicine, Zhejiang University Hangzhou 310003 China Details
Jiangsu Cancer Hospital Nanjing City 211100 China Details
Jiangsu Province Hospital Nanjing 210036 China Details
Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai City 200025 China Details
Shanghai East Hospital, Tongji University Shanghai City 200032 China Details
Fudan University Shanghai Cancer Center Shanghai City 200120 China Details
Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences Tianjin City 300020 China Details
Tianjin Medical University Cancer Institute & Hospital Tianjing 300060 China Details
Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan City 430023 China Details
Henan Cancer Hospital Zhengzhou 450008 China Details
Fakultni Nemocnice Hradec Kralove (FNHK); IV. Interni Hematologicka Klinika Hradec Kralove 500 05 Czechia Details
Fakultni Nemocnice Kralovske Vinohrady (FNKV); Interni Hematologicka Klinika Hradec Kralove 500 05 Czechia Details
Fakultni nemocnice Olomouc Olomouc 775 20 Czechia Details
Fakultni nemocnice Ostrava Ostrava - Poruba 708 52 Czechia Details
Univerzita Karlova v Praze 1. Lekarska Fakulta Prague 128 08 Czechia Details
CHU Amiens - Hopital Sud; Hematologie Clinique et Therapie Cellulaire Amiens 80054 France Details
CHU Angers Angers 49933 France Details
Centre Hospitalier de La Cote Basque; Hematologie Bayonne 64109 France Details
Hopital Jean Minjoz; Hematologie Besancon 25030 France Details
Institut Bergonie Bordeaux 33076 France Details
Institut d'Hématologie de Basse Normandie Caen 14000 France Details
CH Metropole de Savoie CHAMBERY Cedex 73011 France Details
Hopital Henri Mondor; Hematologie Clinique Creteil 94010 France Details
CHU de Dijon - Hopital le Bocage Dijon 21000 France Details
L'Union Mutualiste de la Gestion des Eaux Claires - Institut Daniel Hollard Grenoble 38000 France Details
CHD Vendée La Roche Sur Yon 85025 France Details
Hôpital Albert Michallon; Hematologie Clinique La Tronche 38700 France Details
Clinique Victor Hugo - Centre Jean Bernard Le Mans Cedex 02 72015 France Details
Hôpital Saint Vincent de Paul Lille 59000 France Details
Hopital Claude Huriez; Hematologie Lille 59037 France Details
Hopital Uni Ire Dupuytren; Hematologie Limoges 87042 France Details
Centre Leon Berard Lyon 69008 France Details
CHU Montpellier - Saint ELOI Montpellier 34295 France Details
CHU de Nantes - Hotel Dieu Nantes 44093 France Details
Centre Antoine Lacassagne Nice 06189 France Details
CHU de Nîmes - Hôpital Carémeau Nimes 30029 France Details
Hôpital Saint-Louis; Service d'Hématologie Paris 75475 France Details
Gh Necker Enfants Malades; Hematologie Clinique Paris 75743 France Details
Hopital Saint Jean; Hematologie Perpignan 66046 France Details
Hopital Haut-Leveque - Centre Francois Magendie; Service d'Hematologie Clinique Pessac 33604 France Details
CHU Lyon Sud - Service Hématologie Pierre Benite 69310 France Details
CHU de Poitiers Poitiers 86021 France Details
Centre Hospitalier de Quimper Cornouaille (CHIC); Médecine interne-Maladies du sang Quimper Cedex 29107 France Details
Hopital Pontchaillou; Hematologie Clinique Rennes 35033 France Details
Centre Henri Becquerel; Hematologie Rouen 76038 France Details
Centre Hospitalier de Saint Brieuc - Hôpital Yves Le Foll St Brieuc 22027 France Details
Pôle de Cancérologie - CHU de Saint-Etienne' St Priest en Jarez 42270 France Details
CHRU DE STRASBOURG; Département d'Hématologie et Oncologie Strasbourg 67091 France Details
Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O) Toulouse 31059 France Details
CHU Bretonneau Tours 37044 France Details
CHU de Brabois Vandoeuvre Les Nancy 54511 France Details
CH Bretagne Atlantique; Médecine interne Vannes Cedex 56017 France Details
Institut Gustave Roussy; Unite D'Hematologie Villejuif 94805 France Details
Vivantes Klinikum Am Urban Berlin 10967 Germany Details
Städtisches Klinikum Dessau Dessau-Roßlau 06847 Germany Details
Universitätsklinikum Essen Essen 45147 Germany Details
Universitaetsklinikum Halle (Saale) Halle 06120 Germany Details
Universitaetsklinikum Heidelberg Heidelberg 69120 Germany Details
InVO - Institut für Versorgungsforschung in der Onkologie GbR Koblenz 56068 Germany Details
University of Munich München 81675 Germany Details
Universitatsklinikum Munster Münster 48149 Germany Details
Queen Mary Hospital Hong Kong Hong Kong Details
Queen Elizabeth Hospital Kowloon Hong Kong Details
Azienda Ospedaliera Papa Giovanni XXIII Bergamo Abruzzo 24060 Italy Details
Universita degli Studi Di Brescia - Azienda Ospedaliera Spedali Civili di Brescia Brescia Abruzzo Italy Details
Universita degli Studi di Roma ''La Sapienza" - Clinica Ematologica Rome Abruzzo Italy Details
Azienda Ospedaliera Universitaria Senese Siena Abruzzo 53100 Italy Details
AUSL di Reggio Emilia, IRCCS, P.O. Arcispedale Santa Maria Nuova Reggio Emilia Emilia-Romagna 42100 Italy Details
IRCCS AOU San Martino - IST Genova Liguria 16132 Italy Details
Fondazione IRCCS Istituto Nazionale dei Tumori - s.c. Ematologia Milano Lombardia 20133 Italy Details
Istituto Nazionale dei Tumori Monza Lombardia 20052 Italy Details
Azienda Ospedaliero Universitaria Maggiore della Carita di Novara Novara Piemonte 28100 Italy Details
Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino; Ospedale Molinette Torino Piemonte 10026 Italy Details
Aichi Cancer Center Aichi 464-8681 Japan Details
Chiba University Hospital Chiba 260-8677 Japan Details
Chiba Cancer Center Chiba 260-8717 Japan Details
National Cancer Center Hospital East Chiba 277-8577 Japan Details
National Hospital Organization Kyushu Cancer Center Fukuoka 811-1395 Japan Details
Kyushu University Hospital Fukuoka 812-8582 Japan Details
Hiroshima University Hospital Hiroshima 734-8551 Japan Details
Hokkaido University Hospital Hokkaido 060-8648 Japan Details
Kobe City Medical Center General Hospital Hyogo 650-0047 Japan Details
Tokai University Hospital Kanagawa 259-1193 Japan Details
Kumamoto University Hospital Kumamoto 860-8556 Japan Details
University Hospital Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan Details
Tohoku University Hospital Miyagi 980-8574 Japan Details
Osaka Metropolitan University Hospital Osaka 545-8586 Japan Details
Osaka University Hospital Osaka 565-0871 Japan Details
Kindai University Hospital Osaka 589-8511 Japan Details
Jichi Medical University Hospital Tochigi 329-0498 Japan Details
National Cancer Center Hospital Tokyo 104-0045 Japan Details
The Cancer Institute Hospital of JFCR Tokyo 135-8550 Japan Details
Inje University Busan Paik Hospital Busan 47392 Korea, Republic of Details
Pusan National University Hospital Busan 49241 Korea, Republic of Details
National Cancer Center; Medical Oncology Gyeonggi-do 410-769 Korea, Republic of Details
Seoul National University Hospital Seoul 03080 Korea, Republic of Details
Severance Hospital Seoul 03722 Korea, Republic of Details
Asan Medical Center Seoul 05505 Korea, Republic of Details
Samsung Medical Center Seoul 06351 Korea, Republic of Details
Pusan National University Yangsan Hospital; hemato-oncology Yangsan Korea, Republic of Details
Auckland City Hospital, Cancer and Blood Research Auckland 1023 New Zealand Details
Canterbury Health Laboratories; Immunology/Rheumatology Christchurch 8140 New Zealand Details
Waikato Hospital Hamilton 3248 New Zealand Details
Palmerston North Hospital Palmerston North 4410 New Zealand Details
Samodzielny Publiczny Zakład Opieki Zdrowotnej Zespół Szpitali Miejskich w Chorzowie Chorzów 41-500 Poland Details
Malopolskie Centrum Medyczne Krakow 30-510 Poland Details
SPZOZ Ministerstwa Spraw Wewnętrznych i Administracji w Poznaniu; Oddział Hematologii Poznań 60-631 Poland Details
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie Warszawa 02-781 Poland Details
Wojskowy Instytut Medyczny Warszawa 04-141 Poland Details
Wojewódzki Szpital Specjalistyczny im. M. Kopernika; Klinika Hematologii UM w Łodzi Łódź 93-510 Poland Details
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic Kazan Tatarstan 420029 Russian Federation Details
Penza Regional Oncology Dispensary Penza 440071 Russian Federation Details
Leningrad Regional Clinical Hospital St Petersburg 194291 Russian Federation Details
Institut Catala d Oncologia Hospitalet Hospitalet de Llobregat Barcelona 08908 Spain Details
Hospital Universitario Puerta de Hierro - Majadahonda Majadahonda Madrid 28220 Spain Details
Complejo Hospitalario de Navarra Pamplona Navarra 31008 Spain Details
Hospital de la Santa Creu i Sant Pau Barcelona 08025 Spain Details
Hospital Universitari Vall d'Hebron Barcelona 08035 Spain Details
Hospital Clinic Barcelona Barcelona 08036 Spain Details
Hospital San Pedro de Alcantara Caceres 10003 Spain Details
Hospital Universitari Dr. Josep Trueta Girona 17007 Spain Details
Hospital Universitario La Paz Madrid 280146 Spain Details
Hospital Quiron Madrid Madrid 28033 Spain Details
Fundación Jimenez Díaz Madrid 28040 Spain Details
Hospital Universitario Virgen de la Victoria Malaga 29010 Spain Details
Hospital Universitario Virgen del Rocio Sevilla 41013 Spain Details
Hirslanden Medical Center, Tumorzentrum Aarau 5000 Switzerland Details
Universitätsspital Basel Gynäkologie - Onkologie Basel 4031 Switzerland Details
Hopital Cantonal Universitaire De Geneve Genève 1211 Switzerland Details
Kaohsiung Medical University Hospital, Cancer Center Kaohsiung 807 Taiwan Details
China Medical University Hospital; Clinical Research Center Clinical Pharmacy Taichung 40447 Taiwan Details
Chi-Mei Hospital, Liouying Tainan 736 Taiwan Details
Taipei Veterans General Hospital Taipei City 11217 Taiwan Details
National Taiwan University Hospital Taipei 10002 Taiwan Details
Ankara University Faculty of Medicine Cebeci Hospital Ankara 06700 Turkey Details
Ege Üniversitesi Tip Fakültesi Lzmir 35100 Turkey Details
Dokuz Eylul Universitesi Tip Fakultesi Lzmir 35340 Turkey Details
Vehbi Koc Vakfi (VKV) - Amerikan Hastanesi Teşvi̇ki̇ye 34365 Turkey Details
Communal Institution 'Cherkassy Regional Oncology Dispensary' of the Cherkassy Regional Council Cherkassy Chernihiv Governorate Ukraine Details
MNE Lviv Territorial Medical Association Clinical Hospital for Palliative Care Lviv Chernihiv Governorate 79007 Ukraine Details
Khmelnytskyi Regional Hospital; Department of Hemathology Khmelnytskyi Kharkiv Governorate 29000 Ukraine Details
Feofaniya Center of Haematology and Chemotherapy of Haemoblastosis Kyiv Volhynian Governorate 03143 Ukraine Details
Cambridge University Hospitals NHS Foundation Trust - Addenbrookes Hospital Cambridge CB2 0QQ United Kingdom Details
East Kent Hospitals University NHS Foundation Trust Canterbury CT1 3NG United Kingdom Details
University Hospitals of Leicester NHS Trust - Leicester Royal Infirmary Leicester LE1 5WW United Kingdom Details
Barts Health NHS Trust; Bartholomew's H., King George V Building London EC1A 7BE United Kingdom Details
The Christie NHS Foundation Trust Manchester M20 4BX United Kingdom Details
The Newcastle upon Tyne Hospitals NHS Foundation Trust. Freeman Hospital Newcastle upon Tyne NE7 7DN United Kingdom Details
Nottingham City Hospital; Dept of Haematology Nottingham NG5 1PB United Kingdom Details
Oxford University Hospitals NHS Foundation Trust Oxford OX3 7LE United Kingdom Details
University Hospital Southampton NHS Foundation Trust Southhampton SO16 6YD United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field