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| NCT ID | NCT03516981 |
| Title | A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase II |
| Variant Requirements | Yes |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | ITA | GBR | ESP | CAN | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Arizona Oncology Associates, PC- HAL ( Site 8001) | Tempe | Arizona | 85284 | United States | Details | |
| University of California Davis Comprehensive Cancer Center ( Site 0137) | Sacramento | California | 95817 | United States | Details | |
| University of California San Francisco ( Site 0111) | San Francisco | California | 94143 | United States | Details | |
| UCLA Hematology/Oncology -Santa Monica ( Site 0108) | Santa Monica | California | 90404 | United States | Details | |
| Yale University School of Medicine ( Site 0100) | New Haven | Connecticut | 06520 | United States | Details | |
| Mayo Clinic Florida ( Site 0115) | Jacksonville | Florida | 32224 | United States | Details | |
| University of Maryland ( Site 0136) | Baltimore | Maryland | 21201 | United States | Details | |
| Mayo Clinic Rochester - St. Mary's Hospital ( Site 0117) | Rochester | Minnesota | 55905 | United States | Details | |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0112) | Hackensack | New Jersey | 07601 | United States | Details | |
| Memorial Sloan Kettering Cancer Center ( Site 0113) | New York | New York | 10065 | United States | Details | |
| Weill Cornell Medical College ( Site 0138) | New York | New York | 10065 | United States | Details | |
| Oncology Hematology Care ( Site 8005) | Cincinnati | Ohio | 45242 | United States | Details | |
| University of Pennsylvania ( Site 0132) | Philadelphia | Pennsylvania | 19104 | United States | Details | |
| UPMC Cancer Center/Hillman Cancer Center ( Site 0104) | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| Texas Oncology-Memorial City ( Site 8006) | Houston | Texas | 77024 | United States | Details | |
| Texas Oncology-Tyler ( Site 8003) | Tyler | Texas | 75702 | United States | Details | |
| Emily Couric Clinical Cancer Center ( Site 0134) | Charlottesville | Virginia | 22903 | United States | Details | |
| Northwest Cancer Specialists, P.C. ( Site 8000) | Vancouver | Washington | 98684 | United States | Details | |
| University of Wisconsin- Madison Carbone Cancer Center ( Site 0130) | Madison | Wisconsin | 53792 | United States | Details | |
| Blacktown Hospital Western Sydney Local Health District ( Site 0200) | Blacktown | New South Wales | 2148 | Australia | Details | |
| Gallipoli Medical Research Foundation ( Site 0202) | Brisbane | Queensland | 4120 | Australia | Details | |
| Fiona Stanley Hospital ( Site 0201) | Murdoch | Western Australia | 6150 | Australia | Details | |
| The Ottawa Hospital ( Site 0306) | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Sunnybrook Health Science Centre ( Site 0304) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0309) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| CIUSSS du Saguenay-Lac-St-Jean ( Site 0305) | Chicoutimi | Quebec | G7H 5H6 | Canada | Details | |
| Jewish General Hospital ( Site 0307) | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0310) | Montreal | Quebec | H3T 1M5 | Canada | Details | |
| Prince of Wales Hospital ( Site 1801) | Hong Kong | 000 | Hong Kong | Details | ||
| Queen Mary Hospital ( Site 1800) | Hong Kong | Hong Kong | Details | |||
| St James Hospital ( Site 2200) | Dublin | D08 K0Y5 | Ireland | Details | ||
| Mid Western Cancer Centre ( Site 2201) | Limerick | V94 YVH0 | Ireland | Details | ||
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0702) | Meldola | Emilia-Romagna | 47014 | Italy | Details | |
| Istituto Clinico Humanitas Research Hospital ( Site 0700) | Rozzano | Lombardia | 20089 | Italy | Details | |
| AOU San Luigi Gonzaga di Orbassano ( Site 0707) | Orbassano | Torino | 10043 | Italy | Details | |
| AULSS21 Regione Veneto Ospedale Mater Salutis - Legnago ( Site 0701) | Legnago | Verona | 37045 | Italy | Details | |
| Azienda Ospedaliera Papardo ( Site 0706) | Messina | 98158 | Italy | Details | ||
| Seconda Universita degli Studi di Napoli ( Site 0704) | Napoli | 80131 | Italy | Details | ||
| Fondazione Policlinico Universitario A. Gemelli ( Site 0703) | Roma | 00168 | Italy | Details | ||
| Azienda Ospedaliera Universitaria Senese ( Site 0705) | Siena | 53100 | Italy | Details | ||
| National Cancer Center Hospital ( Site 2001) | Tokyo | 104-0045 | Japan | Details | ||
| The Cancer Institute Hospital of JFCR ( Site 2000) | Tokyo | 135-8550 | Japan | Details | ||
| Seoul National University Bundang Hospital ( Site 0803) | Seongnam-si | Kyonggi-do | 13620 | Korea, Republic of | Details | |
| Asan Medical Center ( Site 0801) | Songpa-gu | Seoul | 05505 | Korea, Republic of | Details | |
| Seoul National University Hospital ( Site 0800) | Seoul | 03080 | Korea, Republic of | Details | ||
| Severance Hospital Yonsei University Health System ( Site 0802) | Seoul | 03722 | Korea, Republic of | Details | ||
| Samsung Medical Center ( Site 0805) | Seoul | 06351 | Korea, Republic of | Details | ||
| Dolnoslaskie Centrum Onkologii. ( Site 0993) | Wroclaw | Dolnoslaskie | 53-413 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( | Warszawa | Mazowieckie | 02-781 | Poland | Details | |
| MED-POLONIA Sp. z o.o. ( Site 0907) | Poznan | Wielkopolskie | 60-693 | Poland | Details | |
| Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1003) | Ufa | Baskortostan, Respublika | 450054 | Russian Federation | Details | |
| The Loginov Moscow Clinical Scientific Center ( Site 1008) | Moscow | Moskva | 111123 | Russian Federation | Details | |
| N.N. Blokhin NMRCO ( Site 1000) | Moscow | Moskva | 115478 | Russian Federation | Details | |
| Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site | Omsk | Omskaya Oblast | 644013 | Russian Federation | Details | |
| SBHI Leningrad Regional Clinical Hospital ( Site 1001) | Saint Petersburg | Sankt-Peterburg | 194291 | Russian Federation | Details | |
| St Petersburg City Clinical Oncology Dispensary ( Site 1002) | St. Petersburg | Sankt-Peterburg | 198255 | Russian Federation | Details | |
| Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1005) | Kazan | Tatarstan, Respublika | 420029 | Russian Federation | Details | |
| National Cancer Centre Singapore ( Site 1900) | Singapore | Central Singapore | 169610 | Singapore | Details | |
| National University Hospital ( Site 1901) | Singapore | South West | 119074 | Singapore | Details | |
| MPOC ( Site 2310) | Groenkloof Pretoria | Gauteng | 0181 | South Africa | Details | |
| Wits Clinical Research ( Site 2313) | Parktown-Johannesburg | Gauteng | 2193 | South Africa | Details | |
| Univ. Pretoria and Steve Biko Academic Hospitals ( Site 2315) | Pretoria | Gauteng | 0002 | South Africa | Details | |
| Sandton Oncology Medical Group PTY LTD ( Site 2316) | Sandton | Gauteng | 2196 | South Africa | Details | |
| Vaal Triangle Oncology Centre ( Site 2314) | Vereeniging | Gauteng | 1939 | South Africa | Details | |
| Umhlanga Oncolgy Center ( Site 2311) | Umhlanga | Kwazulu-Natal | 4320 | South Africa | Details | |
| Cape Town Oncology Trials Pty Ltd ( Site 2312) | Kraaifontein | Western Cape | 7570 | South Africa | Details | |
| Hospital General Universitari Vall d Hebron ( Site 1100) | Barcelona | 08035 | Spain | Details | ||
| Hospital Universitario Ramon y Cajal ( Site 1101) | Madrid | 28034 | Spain | Details | ||
| Hospital Universitario 12 de Octubre ( Site 1102) | Madrid | 28041 | Spain | Details | ||
| Kantonsspital St. Gallen ( Site 2102) | St. Gallen | Aargau | 9007 | Switzerland | Details | |
| Universitaetsspital Basel ( Site 2104) | Basel | Basel-Stadt | 4031 | Switzerland | Details | |
| Hopitaux Universitaires de Geneve HUG ( Site 2106) | Geneva | Geneve | 1211 | Switzerland | Details | |
| Kantonsspital Graubuenden ( Site 2103) | Chur | Grisons | 7000 | Switzerland | Details | |
| Universitaetsspital Zuerich ( Site 2100) | Zuerich | Zurich | 8091 | Switzerland | Details | |
| Kaohsiung Chang Gung Memorial Hospital ( Site 1203) | Kaohsiung | 83301 | Taiwan | Details | ||
| National Cheng Kung University Hospital ( Site 1202) | Tainan | 704 | Taiwan | Details | ||
| National Taiwan University Hospital ( Site 1200) | Taipei | 10048 | Taiwan | Details | ||
| Taipei Veterans General Hospital ( Site 1204) | Taipei | 11217 | Taiwan | Details | ||
| Cambridge University Hospitals NHS Trust ( Site 1306) | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details | |
| University College London Hospital NHS Foundation Trust ( Site 1308) | London | London, City Of | NW1 2PG | United Kingdom | Details | |
| Derriford Hospital ( Site 1301) | Plymouth | PL6 8DH | United Kingdom | Details |