Clinical Trial Detail


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NCT ID NCT03516981
Title A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)
Recruitment Recruiting
Gender both
Phase Phase II
Variant Requirements Yes
Sponsors Merck Sharp & Dohme Corp.

lung non-small cell carcinoma


MK-1308 + Pembrolizumab

MK-4280 + Pembrolizumab

Lenvatinib + Pembrolizumab

Age Groups: adult | senior
Covered Countries USA | CAN

Facility Status City State Zip Country Details
Arizona Oncology Associates, PC- HAL ( Site 8001) Completed Tempe Arizona 85284 United States Details
University of California Davis Comprehensive Cancer Center ( Site 0137) Recruiting Sacramento California 95817 United States Details
University of California San Francisco ( Site 0111) Recruiting San Francisco California 94143 United States Details
UCLA Hematology/Oncology -Santa Monica ( Site 0108) Recruiting Santa Monica California 90404 United States Details
Yale University School of Medicine ( Site 0100) Recruiting New Haven Connecticut 06510 United States Details
Mayo Clinic Florida ( Site 0115) Recruiting Jacksonville Florida 32224 United States Details
University of Maryland ( Site 0136) Recruiting Baltimore Maryland 21201 United States Details
Mayo Clinic Rochester - St. Mary's Hospital ( Site 0117) Recruiting Rochester Minnesota 55905 United States Details
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0112) Recruiting Hackensack New Jersey 07601 United States Details
Memorial Sloan Kettering Cancer Center ( Site 0113) Recruiting New York New York 10065 United States Details
Weill Cornell Medical College ( Site 0138) Recruiting New York New York 10065 United States Details
Oncology Hematology Care ( Site 8005) Completed Cincinnati Ohio 45242 United States Details
University of Pennsylvania ( Site 0132) Recruiting Philadelphia Pennsylvania 19104 United States Details
UPMC Cancer Center/Hillman Cancer Center ( Site 0104) Recruiting Pittsburgh Pennsylvania 15232 United States Details
Texas Oncology-Memorial City ( Site 8006) Completed Houston Texas 77024 United States Details
Texas Oncology-Tyler ( Site 8003) Recruiting Tyler Texas 75702 United States Details
Emily Couric Clinical Cancer Center ( Site 0134) Recruiting Charlottesville Virginia 22903 United States Details
Northwest Cancer Specialists, P.C. ( Site 8000) Completed Vancouver Washington 98684 United States Details
University of Wisconsin- Madison Carbone Cancer Center ( Site 0130) Recruiting Madison Wisconsin 53792 United States Details
Blacktown Hospital Western Sydney Local Health District ( Site 0200) Completed Blacktown New South Wales 2148 Australia Details
Greenslopes Private Hospital ( Site 0202) Completed Greenslopes Queensland 4120 Australia Details
Fiona Stanley Hospital ( Site 0201) Recruiting Murdoch Western Australia 6150 Australia Details
The Ottawa Hospital ( Site 0306) Recruiting Ottawa Ontario K1H 8L6 Canada Details
Sunnybrook Health Science Centre ( Site 0304) Recruiting Toronto Ontario M4N 3M5 Canada Details
Princess Margaret Cancer Centre ( Site 0309) Recruiting Toronto Ontario M5G 2M9 Canada Details
CIUSSS du Saguenay-Lac-St-Jean ( Site 0305) Recruiting Chicoutimi Quebec G7H 5H6 Canada Details
Jewish General Hospital ( Site 0307) Recruiting Montreal Quebec H3T 1E2 Canada Details
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0310) Recruiting Montreal Quebec H3T 1M5 Canada Details
Prince of Wales Hospital ( Site 1801) Recruiting Hong Kong Hong Kong Details
Queen Mary Hospital ( Site 1800) Recruiting Hong Kong Hong Kong Details
St James Hospital ( Site 2200) Completed Dublin D08 K0Y5 Ireland Details
Mid Western Cancer Centre ( Site 2201) Completed Limerick Ireland Details
Azienda Ospedaliera Papardo ( Site 0706) Recruiting Messina Abruzzo 98158 Italy Details
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0702) Recruiting Meldola Emilia-Romagna 47014 Italy Details
Istituto Clinico Humanitas Research Hospital ( Site 0700) Recruiting Rozzano Lombardia 20089 Italy Details
AOU San Luigi Gonzaga di Orbassano ( Site 0707) Recruiting Orbassano Torino 10043 Italy Details
Azienda Ospedaliera Universitaria Senese ( Site 0705) Recruiting Siena Toscana 53100 Italy Details
AULSS21 Regione Veneto Ospedale Mater Salutis - Legnago ( Site 0701) Recruiting Legnago Verona 37045 Italy Details
Seconda Universita degli Studi di Napoli ( Site 0704) Recruiting Napoli 80131 Italy Details
Fondazione Policlinico Universitario A. Gemelli ( Site 0703) Recruiting Roma 00168 Italy Details
National Cancer Center Hospital ( Site 2001) Active, not recruiting Tokyo 104-0045 Japan Details
The Cancer Institute Hospital of JFCR ( Site 2000) Recruiting Tokyo 135-8550 Japan Details
Seoul National University Bundang Hospital ( Site 0803) Recruiting Seongnam-si Kyonggi-do 13620 Korea, Republic of Details
Asan Medical Center ( Site 0801) Recruiting Songpa-gu Seoul 05505 Korea, Republic of Details
Seoul National University Hospital ( Site 0800) Completed Seoul 03080 Korea, Republic of Details
Severance Hospital Yonsei University Health System ( Site 0802) Completed Seoul 03722 Korea, Republic of Details
Samsung Medical Center ( Site 0805) Recruiting Seoul 06351 Korea, Republic of Details
Dolnoslaskie Centrum Onkologii. ( Site 0993) Recruiting Wroclaw Dolnoslaskie 53-413 Poland Details
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Recruiting Warszawa Mazowieckie 02-781 Poland Details
MED-POLONIA Sp. z o.o. ( Site 0907) Recruiting Poznan Wielkopolskie 60-693 Poland Details
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1003) Completed Ufa Baskortostan, Respublika 450054 Russian Federation Details
The Loginov Moscow Clinical Scientific Center ( Site 1008) Recruiting Moscow Moskva 111123 Russian Federation Details
N.N. Blokhin NMRCO ( Site 1000) Completed Moscow Moskva 115478 Russian Federation Details
Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site Recruiting Omsk Omskaya Oblast 644013 Russian Federation Details
SBHI Leningrad Regional Clinical Hospital ( Site 1001) Recruiting Saint Petersburg Sankt-Peterburg 194291 Russian Federation Details
St Petersburg City Clinical Oncology Dispensary ( Site 1002) Recruiting St. Petersburg Sankt-Peterburg 198255 Russian Federation Details
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1005) Recruiting Kazan Tatarstan, Respublika 420029 Russian Federation Details
National University Hospital ( Site 1901) Completed Singapore Central Singapore 119074 Singapore Details
National Cancer Centre Singapore ( Site 1900) Recruiting Singapore Central Singapore 169610 Singapore Details
MPOC ( Site 2310) Recruiting Groenkloof Pretoria Gauteng 0181 South Africa Details
Wits Clinical Research ( Site 2313) Recruiting Parktown-Johannesburg Gauteng 2193 South Africa Details
Univ. Pretoria and Steve Biko Academic Hospitals ( Site 2315) Recruiting Pretoria Gauteng 0002 South Africa Details
Sandton Oncology Medical Group PTY LTD ( Site 2316) Recruiting Sandton Gauteng 2196 South Africa Details
Vaal Triangle Oncology Centre ( Site 2314) Recruiting Vereeniging Gauteng 1936 South Africa Details
Umhlanga Oncolgy Center ( Site 2311) Recruiting Umhlanga Kwazulu-Natal 4320 South Africa Details
Cape Town Oncology Trials Pty Ltd ( Site 2312) Recruiting Kraaifontein Western Cape 7570 South Africa Details
Hospital General Universitari Vall d Hebron ( Site 1100) Recruiting Barcelona 08035 Spain Details
Hospital Universitario Ramon y Cajal ( Site 1101) Recruiting Madrid 28034 Spain Details
Hospital Universitario 12 de Octubre ( Site 1102) Recruiting Madrid 28041 Spain Details
Universitaetsspital Basel ( Site 2104) Recruiting Basel Basel-Stadt 4031 Switzerland Details
Hopitaux Universitaires de Geneve HUG ( Site 2106) Completed Geneva Geneve 1211 Switzerland Details
Kantonsspital Graubuenden ( Site 2103) Recruiting Chur Grisons 7000 Switzerland Details
Kantonsspital St. Gallen ( Site 2102) Recruiting St. Gallen Sankt Gallen 9007 Switzerland Details
Universitaetsspital Zuerich ( Site 2100) Recruiting Zuerich Zurich 8091 Switzerland Details
Kaohsiung Chang Gung Memorial Hospital ( Site 1203) Recruiting Kaohsiung 83301 Taiwan Details
National Cheng Kung University Hospital ( Site 1202) Recruiting Tainan 704 Taiwan Details
National Taiwan University Hospital ( Site 1200) Recruiting Taipei 10048 Taiwan Details
Taipei Veterans General Hospital ( Site 1204) Recruiting Taipei 11217 Taiwan Details
Cambridge University Hospitals NHS Trust ( Site 1306) Completed Cambridge Cambridgeshire CB2 0QQ United Kingdom Details
University College London Hospital NHS Foundation Trust ( Site 1308) Recruiting London Essex NW1 2PG United Kingdom Details
Derriford Hospital ( Site 1301) Recruiting Plymouth PL6 8DH United Kingdom Details
*Shaded cells indicate that there was no data available from for the field