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| NCT ID | NCT03553836 |
| Title | Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716) |
| Recruitment | Active, not recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Merck Sharp & Dohme Corp. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult | child |
| Covered Countries | USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| University of Arizona Cancer Center ( Site 0121) | Tucson | Arizona | 85719 | United States | Details | |
| UCSD Moores Cancer Center ( Site 0133) | La Jolla | California | 92037 | United States | Details | |
| The Angeles Clinic and Research Institute ( Site 0029) | Los Angeles | California | 90025 | United States | Details | |
| UCLA Hematology & Oncology ( Site 0130) | Los Angeles | California | 90095 | United States | Details | |
| John Wayne Cancer Institute ( Site 0026) | Santa Monica | California | 90404 | United States | Details | |
| University of Colorado Cancer Center ( Site 0027) | Aurora | Colorado | 80045 | United States | Details | |
| Yale University ( Site 0035) | New Haven | Connecticut | 06511 | United States | Details | |
| Mayo Clinic Florida ( Site 0024) | Jacksonville | Florida | 32224 | United States | Details | |
| Moffitt McKinley Outpatient Center ( Site 0131) | Tampa | Florida | 33612 | United States | Details | |
| Winship Cancer Institute of Emory University ( Site 0046) | Atlanta | Georgia | 30322-1013 | United States | Details | |
| Northside Hospital ( Site 0115) | Atlanta | Georgia | 30341 | United States | Details | |
| Northwestern Medical Group ( Site 0135) | Chicago | Illinois | 60611 | United States | Details | |
| The University of Chicago Medical Center ( Site 0007) | Chicago | Illinois | 60637 | United States | Details | |
| Advocate Medical Group-Park Ridge ( Site 0025) | Park Ridge | Illinois | 60068 | United States | Details | |
| University of Iowa Hospital and Clinics ( Site 0001) | Iowa City | Iowa | 52242 | United States | Details | |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0047) | Baltimore | Maryland | 21287 | United States | Details | |
| Massachusetts General Hospital ( Site 0126) | Boston | Massachusetts | 02114 | United States | Details | |
| Beth Israel Deaconess Medical Center ( Site 0141) | Boston | Massachusetts | 02215 | United States | Details | |
| Dana Farber Cancer Institute ( Site 0124) | Boston | Massachusetts | 02215 | United States | Details | |
| Karmanos Cancer Institute ( Site 0111) | Detroit | Michigan | 48201 | United States | Details | |
| Mayo Clinic [Rochester, MN] ( Site 0016) | Rochester | Minnesota | 55905 | United States | Details | |
| Siteman Cancer Center ( Site 0143) | Saint Louis | Missouri | 63110 | United States | Details | |
| Memorial Sloan Kettering ( Site 0006) | Harrison | New York | 10604 | United States | Details | |
| Laura and Isaac Perlmutter Cancer Center ( Site 0137) | New York | New York | 10016 | United States | Details | |
| Memorial Sloan Kettering Cancer Center ( Site 0142) | New York | New York | 10022 | United States | Details | |
| Mount Sinai Medical Center ( Site 0038) | New York | New York | 10029 | United States | Details | |
| University of Rochester ( Site 0019) | Rochester | New York | 14642 | United States | Details | |
| The Lindner Center for Research and Education at The Christ Hospital ( Site 0004) | Cincinnati | Ohio | 45219 | United States | Details | |
| Stephenson Cancer Center ( Site 0042) | Oklahoma City | Oklahoma | 73104 | United States | Details | |
| Oregon Health & Science University ( Site 0032) | Portland | Oregon | 97239 | United States | Details | |
| Children's Hospital of Pittsburgh UPMC ( Site 0144) | Pittsburgh | Pennsylvania | 15224 | United States | Details | |
| UPMC Hillman Cancer Centers ( Site 0043) | Pittsburgh | Pennsylvania | 15232 | United States | Details | |
| West Cancer Center - East Campus ( Site 0022) | Germantown | Tennessee | 38138 | United States | Details | |
| University of Tennessee Medical Center Knoxville ( Site 0116) | Knoxville | Tennessee | 37920 | United States | Details | |
| University of Texas-MD Anderson Cancer Center ( Site 0134) | Houston | Texas | 77030 | United States | Details | |
| Inova Schar Cancer Institute ( Site 0014) | Fairfax | Virginia | 22031 | United States | Details | |
| VCU Massey Cancer Center ( Site 0008) | Richmond | Virginia | 23298 | United States | Details | |
| Seattle Cancer Care Alliance ( Site 0044) | Seattle | Washington | 98109 | United States | Details | |
| University of Wisconsin Hospital and Clinics ( Site 0030) | Madison | Wisconsin | 53792 | United States | Details | |
| Melanoma Institute Australia ( Site 0856) | North Sydney | New South Wales | 2065 | Australia | Details | |
| Westmead Hospital ( Site 0853) | Westmead | New South Wales | 2145 | Australia | Details | |
| Cairns Base Hospital ( Site 0859) | Cairns | Queensland | 4870 | Australia | Details | |
| Tasman Oncology Research Pty Ltd ( Site 0858) | Southport | Queensland | 4215 | Australia | Details | |
| Princess Alexandra Hospital ( Site 0857) | Woolloongabba | Queensland | 4102 | Australia | Details | |
| Royal Adelaide Hospital ( Site 0861) | Adelaide | South Australia | 5000 | Australia | Details | |
| Ashford Cancer Centre Research ( Site 0860) | Kurralta Park | South Australia | 5037 | Australia | Details | |
| The Alfred Hospital ( Site 0852) | Melbourne | Victoria | 3004 | Australia | Details | |
| Fiona Stanley Hospital ( Site 0851) | Murdoch | Western Australia | 6150 | Australia | Details | |
| GZA Sint Augustinus ( Site 0259) | Wilrijk - Antwerpen | Antwerpen | 2610 | Belgium | Details | |
| Cliniques Universitaires Saint-Luc ( Site 0251) | Brussels | Bruxelles-Capitale, Region De | 1200 | Belgium | Details | |
| Institut Jules Bordet ( Site 0254) | Bruxelles | Bruxelles-Capitale, Region De | 1000 | Belgium | Details | |
| Jessa Ziekenhuis Campus Virga Jesse ( Site 0256) | Hasselt | Limburg | 3500 | Belgium | Details | |
| UZ Gent ( Site 0255) | Gent | Oost-Vlaanderen | 9000 | Belgium | Details | |
| UZ Leuven ( Site 0252) | Leuven | Vlaams-Brabant | 3000 | Belgium | Details | |
| Hospital Erasto Gaertner ( Site 0159) | Curitiba | Parana | 81520-060 | Brazil | Details | |
| Hospital de Caridade de Ijui ( Site 0156) | Ijui | Rio Grande Do Sul | 98700 000 | Brazil | Details | |
| Hospital Sao Vicente de Paulo ( Site 0158) | Passo Fundo | Rio Grande Do Sul | 99010-080 | Brazil | Details | |
| Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 0154) | Porto Alegre | Rio Grande Do Sul | 90610-000 | Brazil | Details | |
| Fundacao Pio XII - Hospital de Cancer de Barretos ( Site 0155) | Barretos | Sao Paulo | 14784-400 | Brazil | Details | |
| Hospital de Clinicas de Rio Preto ( Site 0162) | Sao Jose Do Rio Preto - SP | Sao Paulo | 15090-000 | Brazil | Details | |
| Instituto Nacional do Cancer II ( Site 0160) | Rio de Janeiro | 20220-410 | Brazil | Details | ||
| Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0151) | Sao Paulo | 01246-000 | Brazil | Details | ||
| Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0161) | Sao Paulo | 01321-001 | Brazil | Details | ||
| A.C. Camargo Cancer Center ( Site 0164) | Sao Paulo | 01508-010 | Brazil | Details | ||
| Cross Cancer Institute ( Site 0057) | Edmonton | Alberta | T6G 1Z2 | Canada | Details | |
| CancerCare Manitoba ( Site 0053) | Winnipeg | Manitoba | R3E 0V9 | Canada | Details | |
| Moncton Hospital - Horizon Health Network ( Site 0055) | Moncton | New Brunswick | E1C 6Z8 | Canada | Details | |
| The Ottawa Hospital ( Site 0058) | Ottawa | Ontario | K1H 8L6 | Canada | Details | |
| Sunnybrook Research Institute ( Site 0060) | Toronto | Ontario | M4N 3M5 | Canada | Details | |
| Princess Margaret Cancer Centre ( Site 0059) | Toronto | Ontario | M5G 2M9 | Canada | Details | |
| Hopital Maisonneuve Rosemont ( Site 0056) | Montreal | Quebec | H1T 2M4 | Canada | Details | |
| Jewish General Hospital ( Site 0054) | Montreal | Quebec | H3T 1E2 | Canada | Details | |
| McGill University Health Centre ( Site 0062) | Montreal | Quebec | H4A 3J1 | Canada | Details | |
| CHU de Quebec - Hotel-Dieu de Quebec ( Site 0061) | Quebec | G1R 2J6 | Canada | Details | ||
| Instituto Clinico Oncologico del Sur ( Site 0203) | Temuco | Araucania | 4810469 | Chile | Details | |
| Fundacion Arturo Lopez Perez FALP ( Site 0200) | Santiago | Region M. De Santiago | 7500921 | Chile | Details | |
| Pontificia Universidad Catolica de Chile ( Site 0201) | Santiago | Region M. De Santiago | 8330032 | Chile | Details | |
| Sociedad Medica Aren y Bachero Limitada ( Site 0207) | Santiago | Region M. De Santiago | 8420383 | Chile | Details | |
| Oncocentro ( Site 0204) | Vina del Mar | Valparaiso | 2520598 | Chile | Details | |
| Centro Oncologico Antofagasta ( Site 0206) | Antofagasta | 1240000 | Chile | Details | ||
| Hopital La Timone ( Site 0302) | Marseille | Bouches-du-Rhone | 13385 | France | Details | |
| CHU Dijon Bourgogne ( Site 0320) | Dijon | Cote-d Or | 21000 | France | Details | |
| CHU de Bordeaux- Hopital Saint Andre ( Site 0304) | Bordeaux | Gironde | 33075 | France | Details | |
| Institut Claudius Regaud IUCT Oncopole ( Site 0306) | Toulouse | Haute-Garonne | 31059 | France | Details | |
| Hopital Ambroise Pare Boulogne ( Site 0316) | Boulogne-Billancourt | Hauts-de-Seine | 92100 | France | Details | |
| CHU Montpellier. ( Site 0312) | Montpellier | Herault | 34295 | France | Details | |
| Centre Eugene Marquis ( Site 0305) | Rennes | Ille-et-Vilaine | 35042 | France | Details | |
| CHU Angers ( Site 0321) | Angers | Maine-et-Loire | 49933 | France | Details | |
| CHU de Reims ( Site 0307) | Reims | Marne | 51100 | France | Details | |
| CHRU Lille - Hopital Claude Huriez ( Site 0301) | Lille | Nord | 59037 | France | Details | |
| C.H.U. Lyon Sud ( Site 0303) | Pierre Benite | Rhone | 69495 | France | Details | |
| CHU Amiens Picardie Hopital Nord ( Site 0317) | Amiens | Somme | 80054 | France | Details | |
| Institut Gustave Roussy ( Site 0300) | Villejuif | Val-de-Marne | 94805 | France | Details | |
| Hopital Saint Louis ( Site 0322) | Paris | 75475 | France | Details | ||
| Universitaetsklinikum in Mannheim ( Site 0351) | Mannheim | Baden-Wurttemberg | 68135 | Germany | Details | |
| Universitaetsklinikum Tuebingen ( Site 0353) | Tuebingen | Baden-Wurttemberg | 72076 | Germany | Details | |
| Klinikum der Ludwig-Maximilians-Universitaet Muenchen ( Site 0357) | Muenchen | Bayern | 80337 | Germany | Details | |
| Klinikum Nuernberg Nord ( Site 0355) | Nuernberg | Bayern | 90419 | Germany | Details | |
| Klinikum der Universitaet in Wuerzburg ( Site 0356) | Wuerzburg | Bayern | 97080 | Germany | Details | |
| Elbe Klinikum Buxtehude ( Site 0354) | Buxtehude | Niedersachsen | 21614 | Germany | Details | |
| Medizinische Hochschule Hannover ( Site 0358) | Hannover | Niedersachsen | 30625 | Germany | Details | |
| Klinik und Poliklinik fuer Dermatologie Venerologie und Allergologie ( Site 0361) | Essen | Nordrhein-Westfalen | 45147 | Germany | Details | |
| Universitaetsklinikum Schleswig-Holstein Campus Kiel ( Site 0359) | Kiel | Schleswig-Holstein | 24105 | Germany | Details | |
| SRH Wald-Klinikum Gera GmbH ( Site 0360) | Gera | Thuringen | 07548 | Germany | Details | |
| Universitaetsklinikum Hamburg Eppendorf (UKE) ( Site 0352) | Hamburg | 20246 | Germany | Details | ||
| Soroka Medical Center ( Site 0653) | Beer Sheva | Southern | 8457108 | Israel | Details | |
| Sourasky Medical Center ( Site 0656) | Tel Aviv | Tell Abib | 6423906 | Israel | Details | |
| HaEmek Medical Center ( Site 0655) | Afula | 1834111 | Israel | Details | ||
| Rambam Medical Center ( Site 0654) | Haifa | 3109601 | Israel | Details | ||
| Hadassah Ein Kerem Medical Center ( Site 0651) | Jerusalem | 9112001 | Israel | Details | ||
| Chaim Sheba Medical Center. ( Site 0652) | Ramat Gan | 5262000 | Israel | Details | ||
| Shamir Medical Center-Assaf Harofeh ( Site 0657) | Zerifin | 70300 | Israel | Details | ||
| Istituto Scientifico Romagnolo per Studio e Cura Tumori IRST ( Site 0403) | Meldola | Forli-Cesena | 47014 | Italy | Details | |
| IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 0406) | Bari | 70124 | Italy | Details | ||
| ASST Papa Giovanni XXIII ( Site 0402) | Bergamo | 24127 | Italy | Details | ||
| IRCCS A.O.U. San Martino - IST ( Site 0404) | Genova | 16132 | Italy | Details | ||
| Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0408) | Milano | 20133 | Italy | Details | ||
| Istituto Nazionale Tumori Fondazione Pascale ( Site 0400) | Napoli | 80131 | Italy | Details | ||
| IRCCS Istituto Oncologico Veneto ( Site 0407) | Padova | 35128 | Italy | Details | ||
| IDI - Istituto Dermopatico dell'Immacolata ( Site 0405) | Roma | 00167 | Italy | Details | ||
| Azienda Ospedaliero Universitaria Senese ( Site 0401) | Siena | 53100 | Italy | Details | ||
| National Cancer Center Hospital ( Site 0910) | Tokyo | 104-0045 | Japan | Details | ||
| Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 0769) | Bydgoszcz | Kujawsko-pomorskie | 85-796 | Poland | Details | |
| Pratia MCM Krakow ( Site 0773) | Krakow | Malopolskie | 30-510 | Poland | Details | |
| Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0751) | Warszawa | Mazowieckie | 02-781 | Poland | Details | |
| Instytut Pomnik Centrum Zdrowia Dziecka ( Site 0759) | Warszawa | Mazowieckie | 04-730 | Poland | Details | |
| Kliniczny Szpital Wojewodzki Nr 1 ( Site 0758) | Rzeszow | Podkarpackie | 35-055 | Poland | Details | |
| Uniwersyteckie Centrum Kliniczne ( Site 0770) | Gdansk | Pomorskie | 80-402 | Poland | Details | |
| Beskidzkie Centrum Onkologii im. Jana Pawla II ( Site 0754) | Bielsko-Biala | Slaskie | 43-300 | Poland | Details | |
| Uniwersyteckie Centrum Kliniczne Slaskiego Uniwersytetu Medycznego ( Site 0757) | Katowice | Slaskie | 40-514 | Poland | Details | |
| LIFTMED ( Site 0765) | Rybnik | Slaskie | 44-200 | Poland | Details | |
| Szpital Kliniczny im. Heliodora Swiecickiego Uniwers Medyczn ( Site 0753) | Poznan | Wielkopolskie | 60-780 | Poland | Details | |
| Cancer Care Langenhoven Drive Oncology Centre ( Site 0812) | Port Elizabeth | Eastern Cape | 6045 | South Africa | Details | |
| Sandton Oncology Medical Group PTY LTD ( Site 0801) | Johannesburg | Gauteng | 2196 | South Africa | Details | |
| Charlotte Maxeke Johannesburg Academic Hospital ( Site 0811) | Parktown | Gauteng | 2196 | South Africa | Details | |
| Wilgers Oncology Centre ( Site 0806) | Pretoria | Gauteng | 0081 | South Africa | Details | |
| MPOC ( Site 0803) | Pretoria | Gauteng | 0181 | South Africa | Details | |
| Cancercare ( Site 0810) | Cape Town | Limpopo | 7700 | South Africa | Details | |
| Cape Town Oncology Trials Pty Ltd ( Site 0807) | Kraaifontein | Western Cape | 7570 | South Africa | Details | |
| Onkologikoa - Instituto Oncologico de San Sebastian ( Site 0457) | San Sebastian | Gipuzkoa | 20014 | Spain | Details | |
| Hospital General Universitario de Valencia ( Site 0451) | Valencia | Valenciana, Comunitat | 46014 | Spain | Details | |
| Hospital General Universitari Vall d Hebron ( Site 0456) | Barcelona | 08035 | Spain | Details | ||
| Hospital Clinic de Barcelona ( Site 0452) | Barcelona | 08036 | Spain | Details | ||
| Hospital General Universitario Gregorio Maranon ( Site 0454) | Madrid | 28009 | Spain | Details | ||
| Hospital Universitario Virgen Macarena ( Site 0455) | Sevilla | 41009 | Spain | Details | ||
| Universitaetsspital Basel ( Site 0554) | Basel | Basel-Stadt | 4031 | Switzerland | Details | |
| Universitaetsspital Bern ( Site 0552) | Bern | Berne | 3010 | Switzerland | Details | |
| Hopitaux Universitaires de Geneve HUG ( Site 0556) | Geneva | Geneve | 1211 | Switzerland | Details | |
| Kantonsspital Graubuenden ( Site 0555) | Chur | Grisons | 7000 | Switzerland | Details | |
| Kantonsspital St. Gallen ( Site 0559) | St. Gallen | Sankt Gallen | 9007 | Switzerland | Details | |
| Oncological Institute of Southern Switzerland ( Site 0557) | Bellinzona | Ticino | 6500 | Switzerland | Details | |
| Centre Hospitalier Universitaire Vaudois ( Site 0553) | Lausanne | Vaud | 1011 | Switzerland | Details | |
| Hopital du Valais ( Site 0558) | Sion | Wallis | 1951 | Switzerland | Details | |
| Universitaetsspital Zuerich ( Site 0551) | Zuerich | Zurich | 8091 | Switzerland | Details | |
| Addenbrooke's Hospital in Cambridge ( Site 0600) | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom | Details | |
| Guy s & St Thomas NHS Foundation Trust ( Site 0601) | London | London, City Of | SE1 9RT | United Kingdom | Details | |
| Royal Marsden Hospital - Fulham Road London ( Site 0613) | London | London, City Of | SW3 6JJ | United Kingdom | Details | |
| The Royal Marsden NHS Foundation Trust. ( Site 0612) | Sutton | Surrey | SM2 5PT | United Kingdom | Details | |
| Christie NHS Foundation Trust ( Site 0604) | Manchester | M20 4GJ | United Kingdom | Details |