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NCT ID NCT03726879
Title A Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorubicin + Cyclophosphamide Followed By Paclitaxel + Trastuzumab + Pertuzumab In Early Her2-Positive Breast Cancer (IMpassion050)
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Hoffmann-La Roche
Indications

Her2-receptor positive breast cancer

Therapies

Cyclophosphamide + Doxorubicin

Atezolizumab + Cyclophosphamide + Doxorubicin

Atezolizumab + Paclitaxel + Pertuzumab + Trastuzumab

Atezolizumab + Pertuzumab + Trastuzumab

Pertuzumab + Trastuzumab

Paclitaxel + Pertuzumab + Trastuzumab

Age Groups: adult | senior
Covered Countries USA | ITA | ESP | DEU | CAN

Facility Status City State Zip Country Details
HCA Midwest Division Kansas City Missouri 64132 United States Details
New York University Medical Center PRIME; NYU Langone Medical Center New York New York 10016 United States Details
Tennessee Oncology Nashville Tennessee 37203 United States Details
Hospital Sao Rafael - HSR Salvador BA 41253-190 Brazil Details
Hospital Araujo Jorge; Departamento de Ginecologia E Mama Goiania GO 74605-070 Brazil Details
Hospital Sao Lucas - PUCRS Porto Alegre RS 90610-000 Brazil Details
Hospital Nossa Senhora da Conceicao Porto Alegre RS 91350-200 Brazil Details
Hospital Perola Byington Sao Paulo SP 01317-000 Brazil Details
Tom Baker Cancer Centre-Calgary Calgary Alberta T2N 4N2 Canada Details
BCCA-Vancouver Cancer Centre Vancouver British Columbia V5Z 4E6 Canada Details
Jewish General Hospital Montreal Quebec H3T 1E2 Canada Details
Hopital du Saint Sacrement Quebec City Quebec G1S 4L8 Canada Details
Masarykuv onkologicky ustav Brno 656 53 Czechia Details
Fakultni nemocnice Olomouc; Onkologicka klinika Olomouc 779 00 Czechia Details
Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH; Klinik für Senologie / Brustzentrum Essen 45136 Germany Details
Praxis für Interdisziplinäre Onkologie und Hämatologie GbR Freiburg 79110 Germany Details
Kooperatives Mammazentrum Hamburg Krankenhaus Jerusalem Hamburg 20357 Germany Details
Sankt Elisabeth Krankenhaus; Gynaekology Leipzig 04277 Germany Details
Rotkreuzklinikum München; Frauenklinik Muenchen 80637 Germany Details
Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe Münster 48149 Germany Details
St. Vincenz-Krankenhaus Paderborn; Haus 3 Frauenklinik Paderborn 33098 Germany Details
Universitätsfrauenklinik Ulm; Abteilung Gynäkologie Ulm 89075 Germany Details
Istituto Nazionale Tumori Irccs Fondazione g. PASCALE;U.O.C. Oncologia Medica Senologica Napoli Campania 80131 Italy Details
Università degli Studi Federico II; Clinica di Oncologia Medica Napoli Campania 80131 Italy Details
Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica Aviano Friuli-Venezia Giulia 33081 Italy Details
Policlinico Universitario Agostino Gemelli Roma Lazio 00168 Italy Details
ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica Brescia Lombardia 25123 Italy Details
ASST DI MONZA; Oncologia Medica Monza Lombardia 20900 Italy Details
Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia Rozzano Lombardia 20089 Italy Details
Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico Candiolo Piemonte 10060 Italy Details
IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II Padova Veneto 35128 Italy Details
National Hospital Organization Shikoku Cancer Center Ehime 791-0280 Japan Details
Fukushima Medical University Hospital Fukushima 960-1295 Japan Details
Hiroshima City Hiroshima Citizens Hospital Hiroshima 730-8518 Japan Details
Hiroshima University Hospital Hiroshima 734-8551 Japan Details
National Hospital Organization Hokkaido Cancer Center Hokkaido 003-0804 Japan Details
Hyogo Cancer Center Hyogo 673-0021 Japan Details
Kanagawa Cancer Center Kanagawa 241-8515 Japan Details
Tokai University Hospital Kanagawa 259-1193 Japan Details
Kumamoto Shinto General Hospital Kumamoto 862-8655 Japan Details
Niigata Cancer Center Hospital Niigata 951-8566 Japan Details
Saitama Medical University International Medical Center Saitama 350-1298 Japan Details
Toranomon Hospital Tokyo 105-8470 Japan Details
Showa University Hospital Tokyo 142-8666 Japan Details
Gachon University Gil Medical Center Incheon 21565 Korea, Republic of Details
Korea University Anam Hospital Seoul 02841 Korea, Republic of Details
Seoul National University Hospital Seoul 03080 Korea, Republic of Details
Samsung Medical Centre; Oncology Seoul 135-170 Korea, Republic of Details
Narodowy Inst.Onkol.im.Sklodowskiej-Curie Panstw.Inst.Bad Gliwice; Centr.Diagn.i Lecz.Chor.Piersi Gliwice 44-101 Poland Details
Regionalny Szpital Specjalistyczny im. W. Bieganskiego; Oddzial Onkologii Klinicznej Grudziądz 86-300 Poland Details
Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii Kraków 30-688 Poland Details
Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad; Klinika Nowtw.Piersi i Chir.Rekonstr Warszawa 02-781 Poland Details
Instytut "Centrum Zdrowia Matki Polki"; Klinika Onkologii Łódź 93-338 Poland Details
FSBI National Medical Research Radiological Center; A. TSYB MEDICAL RADIOLOGICAL RESEARCH CENTER Obninsk Kaluga 249036 Russian Federation Details
Petrov Research Inst. of Oncology Pesochny Leningrad 197758 Russian Federation Details
SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM" Moskva Moskovskaja Oblast 111123 Russian Federation Details
Blokhin Cancer Research Center; Combined Treatment Moskva Moskovskaja Oblast 115478 Russian Federation Details
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic Kazan Tatarstan 420029 Russian Federation Details
City Clinical Oncology Hospital Moscow 143423 Russian Federation Details
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia Badalona Barcelona 08916 Spain Details
Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia El Palmar Murcia 30120 Spain Details
Clinica Universitaria de Navarra; Servicio de Oncologia Pamplona Navarra 31008 Spain Details
Hospital Univ Vall d'Hebron; Servicio de Oncologia Barcelona 08035 Spain Details
Hospital Clínic i Provincial; Servicio de Hematología y Oncología Barcelona 08036 Spain Details
Complejo Asistencial Universitario De Burgos; Servicio de Oncologia Burgos 09006 Spain Details
Hospital Clinico de Granada; Servicio de Oncologia Granada 18016 Spain Details
Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia Jaen 23007 Spain Details
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia Lerida 25198 Spain Details
Clinica Universidad de Navarra Madrid; Servicio de Oncología Madrid 28027 Spain Details
Centro Integral Oncologico Clara Campal; Servicio de Oncología Madrid 28050 Spain Details
Hospital Universitario Virgen Macarena; Servicio de Oncologia Sevilla 41009 Spain Details
Hospital Universitario Virgen del Rocio; Servicio de Oncologia Sevilla 41013 Spain Details
China Medical University Hospital; Surgery Taichung 404 Taiwan Details
Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology Taipei City 11259 Taiwan Details
Mackay Memorial Hospital; Dept of Surgery Taipei 104 Taiwan Details
Chang Gung Medical Foundation - Linkou; Dept of Surgery Taoyuan 333 Taiwan Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field