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NCT ID NCT03898180
Title Study of First-line Pembrolizumab (MK-3475) With Lenvatinib (MK-7902/E7080) in Urothelial Carcinoma Cisplatin-ineligible Participants Whose Tumors Express Programmed Cell Death-Ligand 1 and in Participants Ineligible for Platinum-containing Chemotherapy (MK-7902-011/E7080-G000-317/ LEAP-011)
Recruitment Active, not recruiting
Gender both
Phase Phase III
Variant Requirements Yes
Sponsors Merck Sharp & Dohme Corp.
Indications

urethra transitional cell carcinoma

bladder urothelial carcinoma

renal pelvis transitional cell carcinoma

ureter transitional cell carcinoma

Therapies

Lenvatinib + Pembrolizumab

Pembrolizumab

Age Groups: adult | senior
Covered Countries USA | CAN

Facility Status City State Zip Country Details
Banner MD Anderson Cancer Center ( Site 0016) Gilbert Arizona 85234 United States Details
Community Cancer Institute ( Site 0777) Clovis California 93611 United States Details
University of California Irvine Medical Center ( Site 0078) Orange California 92868 United States Details
John Wayne Cancer Institute ( Site 0017) Santa Monica California 90404 United States Details
Northwest Georgia Oncology Centers PC ( Site 0707) Marietta Georgia 30060 United States Details
University of Chicago ( Site 0039) Chicago Illinois 60637 United States Details
Joliet Oncology Hematology ( Site 0091) Joliet Illinois 60436 United States Details
Quincy Medical Group ( Site 0022) Quincy Illinois 62301 United States Details
New England Cancer Specialists ( Site 0047) Scarborough Maine 04074 United States Details
Karmanos Cancer Institute ( Site 0712) Detroit Michigan 48201 United States Details
Mercy Hospital Saint Louis - David C. Pratt Cancer Center ( Site 0095) Saint Louis Missouri 63141 United States Details
Comprehensive Cancer Centers of Nevada ( Site 0005) Las Vegas Nevada 89169 United States Details
St. Peter's Hospital Cancer Care Center ( Site 0042) Albany New York 12208 United States Details
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0002) New York New York 10016 United States Details
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0774) Tulsa Oklahoma 74146 United States Details
Thomas Jefferson University Hospital ( Site 0051) Philadelphia Pennsylvania 19107 United States Details
Medical University of South Carolina-Hollings Cancer Center ( Site 0029) Charleston South Carolina 29425 United States Details
Baylor Scott & White Medical Center - Temple ( Site 0706) Temple Texas 76508 United States Details
Virginia Cancer Institute ( Site 0099) Richmond Virginia 23230 United States Details
Seattle Cancer Care Alliance ( Site 0003) Seattle Washington 98109 United States Details
Cancer Care Northwest ( Site 0009) Spokane Washington 99218 United States Details
Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 0577) Berazategui Buenos Aires B1884BBF Argentina Details
Centro de Urología CDU ( Site 0590) Buenos Aires Caba C1120AAT Argentina Details
Instituto Medico Alexander Fleming ( Site 0578) Buenos Aires Caba C1426ANZ Argentina Details
Centro de Investigaciones Clinicas - Clinica Viedma ( Site 0585) Viedma Rio Negro R8500ACE Argentina Details
Centro Oncológico de Rosario ( Site 0584) Rosario Santa Fe S2000KZE Argentina Details
Instituto de Investigaciones Metabolicas ( Site 0589) Buenos Aires C1012AAR Argentina Details
Centro Medico Dra De Salvo ( Site 0593) Buenos Aires C1426ANZ Argentina Details
CEMAIC ( Site 0581) Cordoba X5008HHW Argentina Details
Centro Oncologico de Integracion Regional. COIR ( Site 0576) Mendoza M5500AYB Argentina Details
Macquarie University ( Site 0151) North Ryde New South Wales 2109 Australia Details
Mater Misericordiae Ltd ( Site 0158) South Brisbane Queensland 4101 Australia Details
Monash Health ( Site 0160) Clayton Victoria 3168 Australia Details
Peninsula Health Frankston Hospital ( Site 0153) Frankston Victoria 3199 Australia Details
Austin Health-Austin Hospital ( Site 0154) Heidelberg Victoria 3084 Australia Details
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0101) Hamilton Ontario L8V 5C2 Canada Details
Lakeridge Health ( Site 0103) Oshawa Ontario L1G 2B9 Canada Details
Sunnybrook Research Institute ( Site 0106) Toronto Ontario M4N 3M5 Canada Details
CIUSSS de l Estrie Centre Hospitalier Universitaire de Sherbrooke ( Site 0102) Sherbrooke Quebec J1H5N4 Canada Details
CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0104) Quebec G1R 2J6 Canada Details
Peking University First Hospital ( Site 0726) Beijing Beijing 100034 China Details
Fifth Medical Center of CPLA General Hospital ( Site 0732) Beijing Beijing 100071 China Details
Peking University Third Hospital ( Site 0727) Beijing Beijing 100089 China Details
Chongqing Cancer Hospital ( Site 0741) Chongging Chongqing 400030 China Details
The First Affiliated Hospital of Xiamen University ( Site 0743) Xiamen Fujian 361003 China Details
Sun Yat-Sen University Cancer Center ( Site 0752) Guangdong Guangdong 510060 China Details
The First Affiliated Hospital of Guangzhou Medical University ( Site 0749) Guangzhou Guangdong 510230 China Details
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ( Site 0746) Guangzhou Guangdong 510289 China Details
Harbin Medical University Cancer Hospital ( Site 0750) Harbin Heilongjiang 150081 China Details
Hubei Cancer Hospital ( Site 0744) Wuhan Hubei 430079 China Details
Hunan Cancer Hospital ( Site 0745) Changsha Hunan 410013 China Details
Nanjing Drum Tower Hospital ( Site 0737) Nanjing Jiangsu 210008 China Details
Fudan University Shanghai Cancer Center ( Site 0721) Shanghai Shanghai 200032 China Details
Zhongshan Hospital Fudan University ( Site 0725) Shanghai Shanghai 200032 China Details
The First Affiliated Hospital of Xi an Jiaotong University ( Site 0738) Xian Shanxi 710061 China Details
Cancer Hospital Affiliated to Xinjiang Medical University ( Site 0751) Urumqi Xinjiang 830011 China Details
Second Affiliated Hospital, Zhejiang University ( Site 0734) Hangzhou Zhejiang 310009 China Details
Zhejiang Provincial People's Hospital ( Site 0735) Hangzhou Zhejiang 310014 China Details
Rigshospitalet ( Site 0680) Copenhagen Hovedstaden 2100 Denmark Details
Herlev Hospital ( Site 0681) Herlev Hovedstaden 2730 Denmark Details
Aarhus Universitets hospital ( Site 0683) Aarhus N Midtjylland 8200 Denmark Details
Aalborg Universitets Hospital ( Site 0684) Aalborg Nordjylland 9000 Denmark Details
Odense Universitetshospital ( Site 0682) Odense Syddanmark 5000 Denmark Details
CHU Poitiers ( Site 0253) Poitiers Ain 86021 France Details
Institut de Cancerologie Strasbourg Europe ( Site 0232) Strasbourg Alsace 67033 France Details
Hopital de la Timone ( Site 0246) Marseille Bouches-du-Rhone 13005 France Details
CHIC Quimper ( Site 0245) Quimper Finistere 29107 France Details
CHU de Bordeaux- Hopital Saint Andre ( Site 0235) Bordeaux Gironde 33075 France Details
Clinique Pasteur ( Site 0252) Tolouse Haute-Garonne 31076 France Details
Centre de Cancerologie du Grand Montpellier ( Site 0249) Montpellier Languedoc-Roussillon 34070 France Details
Centre Rene Gauducheau ICO ( Site 0250) Saint Herblain Loire-Atlantique 44805 France Details
Institut de Cancerologie de l Ouest Site Paul Papin ( Site 0236) Angers Maine-et-Loire 49055 France Details
Centre D Oncologie de Gentilly ( Site 0240) Nancy Meurthe-et-Moselle 54100 France Details
Centre Hospitalier de la Cote Basque ( Site 0239) Bayonne Pyrenees-Atlantiques 64109 France Details
Centre Leon Berard ( Site 0244) Lyon Rhone 69373 France Details
Institut Gustave Roussy ( Site 0243) Villejuif Val-de-Marne 94805 France Details
CHD Vendee-onco-hematologie ( Site 0251) La Roche sur Yon Vendee 85925 France Details
Institut Curie ( Site 0237) Paris 75005 France Details
Klinikum der Eberhard-Karls-Universitaet Tuebingen ( Site 0271) Tuebingen Baden-Wurttemberg 72076 Germany Details
Universitaetsklinikum Giessen und Marburg GmbH ( Site 0284) Marburg Hessen 35032 Germany Details
Helios Kliniken Schwerin GmbH ( Site 0278) Schwerin Mecklenburg-Vorpommern 19049 Germany Details
Universitaetsmedizin Goettingen ( Site 0281) Gottingen Niedersachsen 37075 Germany Details
Universitaetsklinikum Essen ( Site 0274) Essen Nordrhein-Westfalen 45147 Germany Details
Staedtisches Krankenhaus Kiel GmbH ( Site 0285) Kiel Schleswig-Holstein 24116 Germany Details
Universitaetsklinikum Schleswig-Holstein-Campus Lubeck ( Site 0277) Luebeck Schleswig-Holstein 23538 Germany Details
Universitaetsklinikum Hamburg-Eppendorf ( Site 0282) Hamburg 20246 Germany Details
Bacs-Kiskun Megyei Korhaz ( Site 0510) Kecskemet Bacs-Kiskun 6000 Hungary Details
Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce Miskolc Borsod-Abauj-Zemplen 3526 Hungary Details
Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointezet ( Site 0507) Szolnok Jasz-Nagykun-Szolnok 5000 Hungary Details
Markusovszky Egyetemi Oktatokorhaz ( Site 0502) Szombathely Vas 9400 Hungary Details
Bajcsy Zsilinszki Korhaz es Rendelointezet ( Site 0509) Budapest 1106 Hungary Details
Orszagos Onkologiai Intezet ( Site 0503) Budapest 1122 Hungary Details
Uzsoki Utcai Korhaz ( Site 0508) Budapest 1145 Hungary Details
Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 0504) Kaposvar 7400 Hungary Details
Ha Emek Medical Center ( Site 0560) Afula 1834111 Israel Details
Assuta Ashdod Public ( Site 0562) Ashdod 7747629 Israel Details
Rambam Medical Center ( Site 0552) Haifa 3109601 Israel Details
Shaare Zedek Medical Center ( Site 0559) Jerusalem 9103102 Israel Details
Hadassah Ein Kerem Medical Center ( Site 0558) Jerusalem 9112001 Israel Details
Meir Medical Center ( Site 0554) Kfar Saba 4428164 Israel Details
Rabin Medical Center ( Site 0553) Petach-Tikwa 4941492 Israel Details
Sheba Medical Center ( Site 0551) Ramat Gan 5265601 Israel Details
Sourasky Medical Center ( Site 0561) Tel Aviv 6423906 Israel Details
Assaf Harofeh Medical Center ( Site 0556) Zerifin 70300 Israel Details
Ospedale San Raffaele-Oncologia Medica ( Site 0309) Milano Lombardia 20132 Italy Details
ASST Grande Ospedale Metropolitano Niguarda ( Site 0307) Milano Lombardia 20162 Italy Details
Centro di Riferimento Oncologico CRO ( Site 0304) Aviano Pordenone 33081 Italy Details
Istituto Tumori Giovanni Paolo II ( Site 0306) Bari 70124 Italy Details
Policlinico S. Orsola - Malpighi (Bologna) ( Site 0302) Bologna 40138 Italy Details
Azienda Ospedaliera per l Emergenza Cannizzaro ( Site 0305) Catania 95126 Italy Details
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0301) Milano 20133 Italy Details
Azienda Ospedaliera Santa Maria ( Site 0303) Terni 05100 Italy Details
Ospedale Borgo Roma-Oncologia ( Site 0308) Verona 37134 Italy Details
Hirosaki University Hospital ( Site 0123) Hirosaki Aomori 036-8563 Japan Details
National Cancer Center Hospital East ( Site 0128) Kashiwa Chiba 277-8577 Japan Details
Ehime University Hospital ( Site 0137) Toon Ehime 791-0295 Japan Details
Sapporo Medical University Hospital ( Site 0122) Sapporo Hokkaido 060-8543 Japan Details
University of Tsukuba Hospital ( Site 0126) Tsukuba Ibaraki 305-8576 Japan Details
Kitasato University Hospital ( Site 0129) Sagamihara Kanagawa 252-0375 Japan Details
Nara Medical University Hospital ( Site 0133) Kashihara Nara 634-8522 Japan Details
Saitama Medical University International Medical Center ( Site 0125) Hidaka Saitama 350-1298 Japan Details
Yamaguchi University Hospital ( Site 0135) Ube Yamaguchi 755-8505 Japan Details
Akita University Hospital ( Site 0124) Akita 010-8543 Japan Details
Chiba Cancer Center ( Site 0127) Chiba 260-8717 Japan Details
Nagasaki University Hospital ( Site 0136) Nagasaki 852-8501 Japan Details
Osaka City University Hospital ( Site 0132) Osaka 545-8586 Japan Details
Tokushima University Hospital ( Site 0134) Tokushima 770-8503 Japan Details
Medical Hospital, Tokyo Medical And Dental University ( Site 0130) Tokyo 113-8519 Japan Details
Chonnam National University Hwasun Hospital ( Site 0194) Hwasun Gun Jeonranamdo 58128 Korea, Republic of Details
National Cancer Center ( Site 0196) Goyang-si Kyonggi-do 10408 Korea, Republic of Details
Chungnam National University Hospital ( Site 0195) Daejeon Taejon-Kwangyokshi 35015 Korea, Republic of Details
Korea University Anam Hospital ( Site 0197) Seoul 02841 Korea, Republic of Details
Seoul National University Hospital ( Site 0191) Seoul 03080 Korea, Republic of Details
Severance Hospital ( Site 0192) Seoul 03722 Korea, Republic of Details
Veterans Health Service Medical Center ( Site 0198) Seoul 05368 Korea, Republic of Details
Samsung Medical Center ( Site 0193) Seoul 06351 Korea, Republic of Details
Ziekenhuis Rijnstate ( Site 0342) Arnhem Gelderland 6815 AD Netherlands Details
Maastricht Universitair Medisch Centrum - MUMC ( Site 0334) Maastricht Limburg 6229 HX Netherlands Details
VieCuri Medisch Centrum ( Site 0340) Venlo Limburg 5912 BL Netherlands Details
Amphia Ziekenhuis Breda ( Site 0331) Breda Noord-Brabant 4819 EV Netherlands Details
Deventer Ziekenhuis ( Site 0341) Deventer Overijssel 7416 SE Netherlands Details
Haga Ziekenhuis ( Site 0333) Den Haag Zuid-Holland 2545 AA Netherlands Details
Erasmus MC ( Site 0332) Rotterdam Zuid-Holland 3015 GD Netherlands Details
St. Antonius Ziekenhuis ( Site 0335) Utrecht 3543 AZ Netherlands Details
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego ( Site 0535) Wroclaw Dolnoslaskie 50-556 Poland Details
Szpital Wojewodzki ( Site 1062) Tarnow Malopolskie 33-100 Poland Details
Europejskie Centrum Zdrowia Otwock ( Site 0532) Otwock Mazowieckie 05-400 Poland Details
Urologica Praktyka Lekarska Adam Marcheluk ( Site 0543) Siedlce Mazowieckie 08-110 Poland Details
Luxmed Onkologia sp. z o. o. ( Site 0541) Warszawa Mazowieckie 01-748 Poland Details
Szpital Miejski im. Jana Pawła II w Bielsku-Białej ( Site 0542) Bielsko-Biala Slaskie 43-300 Poland Details
GBUZ Leningrad Regional Clinical Oncology Dispensary ( Site 0426) Kuzmolovskiy Settlement Leningradskaya Oblast 188663 Russian Federation Details
Russian Scientific Center of Roentgenoradiology ( Site 0424) Moscow Moskva 117485 Russian Federation Details
Central Clinical Hospital with Polyclinic ( Site 0415) Moscow Moskva 121359 Russian Federation Details
Medical Rehabilitation Center ( Site 0411) Moscow Moskva 125367 Russian Federation Details
Murmansk Regional Oncology Dispensary ( Site 0420) Murmansk Murmanskaya Oblast 183057 Russian Federation Details
Volga District Medical Center Federal Medical and Biological Agency ( Site 0413) Nizhny Novgorod Nizhegorodskaya Oblast 603074 Russian Federation Details
Omsk Clinical Oncology Dispensary ( Site 0418) Omsk Omskaya Oblast 644013 Russian Federation Details
Clinical Hospital Saint Luka ( Site 0421) Saint-Petersburg Sankt-Peterburg 194044 Russian Federation Details
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 0414) Yaroslavl Yaroslavskaya Oblast 150054 Russian Federation Details
Institut Catala d Oncologia Hospital Germans Trias i Pujol ( Site 0351) Badalona Barcelona 08916 Spain Details
ICO L Hospitalet ( Site 0361) Hospitalet de Llobregat Barcelona 08908 Spain Details
Xarxa Assistencial Universitaria Manresa ( Site 0354) Manresa Barcelona 08243 Spain Details
Hospital Teresa Herrera - Chuac ( Site 0357) A Coruna La Coruna 15006 Spain Details
Hospital Universitario HM Sanchinarro ( Site 0356) Madrid Madrid, Comunidad De 28050 Spain Details
Hospital Infanta Cristina ( Site 0355) Badajoz 06080 Spain Details
Hospital General Universitari Vall d Hebron ( Site 0358) Barcelona 08035 Spain Details
Hospital La Princesa ( Site 0862) Madrid 28006 Spain Details
Hospital Universitario Gregorio Maranon ( Site 0352) Madrid 28009 Spain Details
Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 0216) Kaoshiung Kaohsiung 807 Taiwan Details
Kaohsiung Chang Gung Memorial Hospital ( Site 0217) Kaohsiung 83301 Taiwan Details
China Medical University Hospital ( Site 0213) Taichung 40447 Taiwan Details
Taichung Veterans General Hospital ( Site 0214) Taichung 40705 Taiwan Details
National Cheng Kung University Hospital ( Site 0215) Tainan 70403 Taiwan Details
National Taiwan University Hospital ( Site 0211) Taipei 100 Taiwan Details
Taipei Veterans General Hospital ( Site 0212) Taipei 11217 Taiwan Details
Cukurova Universitesi Tıp Fakultesi Balcalı Hastanesi ( Site 0457) Adana 01330 Turkey Details
Ankara Sehir Hastanesi ( Site 0455) Ankara 06800 Turkey Details
Antalya Memorial Hospital Department of Medical Oncology ( Site 0461) Antalya 07020 Turkey Details
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 0454) Istanbul 34098 Turkey Details
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0459) Istanbul 34722 Turkey Details
Ege Universitesi Tulay Aktas Onkoloji Hastanesi ( Site 0462) İzmir 35100 Turkey Details
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 0456) Konya 42080 Turkey Details
Sakarya Universitesi Tip Fakultesi Arastirma Hastanesi ( Site 0460) Sakarya 54290 Turkey Details
Weston Park Hospital ( Site 0387) Sheffield Derbyshire S10 2SJ United Kingdom Details
Queens Hospital-Purple Zone ( Site 0377) Romford Essex RM7 0AG United Kingdom Details
Lister Hospital ( Site 0376) Stevenage Hertfordshire SG1 4AB United Kingdom Details
Kent and Canterbury Hospital ( Site 0390) Canterbury Kent CT1 3NG United Kingdom Details
Royal Preston Hospital ( Site 0379) Preston Lancashire PR2 9HT United Kingdom Details
Saint Bartholomew s Hospital - London ( Site 0386) London London, City Of EC1A 7BE United Kingdom Details
University College London Hospital NHS Foundation Trust ( Site 0380) London London, City Of NW1 2PG United Kingdom Details
Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 0378) London London, City Of W6 8RF United Kingdom Details
Nottingham University Hospital NHS Trust ( Site 0383) Nottingham NG5 1PB United Kingdom Details
Derriford Hospital ( Site 0388) Plymouth PL6 8DH United Kingdom Details
Royal Stoke University Hospital Univ. Hosps of North Midlands NHST ( Site 0392) Stoke-on-Trent ST4 6QG United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field