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NCT ID NCT04210115
Title Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)
Recruitment Recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.
Indications

esophagus adenocarcinoma

gastroesophageal junction adenocarcinoma

Therapies

Cisplatin + Fluorouracil + Pembrolizumab

Fluorouracil + Leucovorin + Oxaliplatin

Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab

Cisplatin + Fluorouracil

Age Groups: adult | senior
Covered Countries USA | ITA | FRA | DEU | CAN | BEL

Facility Status City State Zip Country Details
MemorialCare Health System - Long Beach Medical Center-Oncology ( Site 0691) Recruiting Long Beach California 90806 United States Details
Columbus Regional Research Institute ( Site 0047) Recruiting Columbus Georgia 31904 United States Details
University of Kansas Cancer Center ( Site 0023) Recruiting Westwood Kansas 66205 United States Details
Cancer Center of Kansas ( Site 0058) Recruiting Wichita Kansas 67214 United States Details
University Medical Center ( Site 0035) Recruiting New Orleans Louisiana 70112 United States Details
Greater Baltimore Medical Center ( Site 0031) Recruiting Baltimore Maryland 21204 United States Details
Dana Farber Cancer Center ( Site 0034) Recruiting Boston Massachusetts 02215 United States Details
Henry Ford Hospital ( Site 0685) Recruiting Detroit Michigan 48202 United States Details
University of Missouri ( Site 0688) Completed Columbia Missouri 65212 United States Details
Rutgers Cancer Institute of New Jersey ( Site 0695) Recruiting New Brunswick New Jersey 08903 United States Details
Weill Cornell Medical College ( Site 0053) Recruiting New York New York 10065 United States Details
Stephenson Cancer Center ( Site 0044) Recruiting Oklahoma City Oklahoma 73104 United States Details
Oregon Health & Science University Center for Health & Healing 2- CHH2 ( Site 0060) Recruiting Portland Oregon 97239 United States Details
Allegheny Health Network ( Site 0042) Recruiting Pittsburgh Pennsylvania 15212 United States Details
Thompson Cancer Survival Center ( Site 0696) Recruiting Knoxville Tennessee 37916 United States Details
Cancer Care Northwest - Spokane Valley ( Site 0036) Completed Spokane Valley Washington 99216 United States Details
University of Wisconsin Hospital and Clinics ( Site 0033) Recruiting Madison Wisconsin 53792 United States Details
Instituto Medico Alexander Fleming ( Site 0063) Recruiting Buenos Aires Caba C1426ANZ Argentina Details
Fundacion Favaloro ( Site 0061) Recruiting Ciudad de Buenos Aires Caba C1093AAS Argentina Details
Hospital Municipal de Gastroenterologia Dr. Bonorino Udaondo ( Site 0066) Recruiting Buenos Aires C1264AAA Argentina Details
CEMIC ( Site 0064) Recruiting Buenos Aires C1431FWO Argentina Details
UCL Saint Luc ( Site 0162) Recruiting Brussels Bruxelles-Capitale, Region De 1200 Belgium Details
UZ Gent ( Site 0163) Recruiting Gent Oost-Vlaanderen 9000 Belgium Details
UZ Leuven ( Site 0161) Recruiting Leuven Vlaams-Brabant 3000 Belgium Details
AZ Delta ( Site 0165) Recruiting Roeselare West-Vlaanderen 8800 Belgium Details
ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 0088) Recruiting Ijui Rio Grande Do Sul 98700-000 Brazil Details
Hospital Nossa Senhora da Conceicao ( Site 0087) Recruiting Porto Alegre Rio Grande Do Sul 91350-200 Brazil Details
Clinica de Oncologia Reichow ( Site 0085) Recruiting Blumenau Santa Catarina 89010-340 Brazil Details
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0081) Recruiting Sao Paulo 01246-000 Brazil Details
Cross Cancer Institute ( Site 0010) Recruiting Edmonton Alberta T6G 1Z2 Canada Details
CancerCare Manitoba ( Site 0002) Recruiting Winnipeg Manitoba R3E 0V9 Canada Details
The Ottawa Hospital - Cancer Care ( Site 0008) Recruiting Ottawa Ontario K1H 8L6 Canada Details
Sunnybrook Research Institute ( Site 0012) Recruiting Toronto Ontario M4N 3M5 Canada Details
Princess Margaret Cancer Centre ( Site 0011) Recruiting Toronto Ontario M5G 2M9 Canada Details
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0005) Recruiting Montreal Quebec H2X 0C1 Canada Details
Centro Investigación del Cáncer James Lind ( Site 0106) Recruiting Temuco Araucania 4800827 Chile Details
Centro de Investigacion y desarrollo Oncologico SpA - CIDO SpA ( Site 0103) Recruiting Temuco Araucania 4810218 Chile Details
Hospital Regional de Concepcion ( Site 0105) Recruiting Concepcion Biobio 4070038 Chile Details
Centro de Cancer Nuestra Senora de la Esperanza ( Site 0104) Recruiting Santiago Region M. De Santiago 8330024 Chile Details
Anhui Provincial Hospital-Oncology Radiotherapy Department ( Site 0531) Recruiting Hefei Anhui 230071 China Details
900 Hospital of the Joint ( Site 0509) Recruiting Fuzhou Fujian 350025 China Details
The First Affiliated Hospital of Xiamen University ( Site 0538) Recruiting Xiamen Fujian 361003 China Details
Hubei Cancer Hospital ( Site 0514) Recruiting Wuhan Hubei 430079 China Details
Hunan Cancer Hospital ( Site 0515) Recruiting Changsha Hunan 410006 China Details
Huai an First People s Hospital ( Site 0526) Recruiting Huai An Jiangsu 223001 China Details
Jiangsu Cancer Hospital ( Site 0519) Recruiting Nanjing Jiangsu 210000 China Details
The Affiliated Hospital of Xuzhou Medical University ( Site 0522) Recruiting Xuzhou Jiangsu 221002 China Details
Affiliated Hospital of Jiangsu University ( Site 0524) Recruiting Zhenjiang Jiangsu 212000 China Details
Jiangxi Cancer Hospital ( Site 0512) Recruiting Nanchang Jiangxi 330029 China Details
Shanghai Chest Hospital ( Site 0503) Recruiting Shangai Shanghai 200030 China Details
Shanghai Chest Hospital ( Site 0501) Recruiting Shanghai Shanghai 200030 China Details
Zhongshan Hospital Fudan University ( Site 0502) Recruiting Shanghai Shanghai 200032 China Details
Sichuan Cancer Hospital ( Site 0527) Recruiting Chengdu Sichuan 610041 China Details
Tianjin Medical University Cancer Institute & Hospital ( Site 0505) Recruiting Tianjin Tianjin 300060 China Details
Hangzhou First People's Hospital ( Site 0530) Recruiting Hangzhou Zhejiang 310002 China Details
Sir Run Run Shaw Hospital ( Site 0523) Recruiting Hangzhou Zhejiang 310018 China Details
Zhejiang Cancer Hospital ( Site 0529) Recruiting Hangzhou Zhejiang 310022 China Details
Rigshospitalet ( Site 0199) Recruiting Copenhagen Hovedstaden 2100 Denmark Details
Odense Universitetshospital ( Site 0200) Recruiting Odense Syddanmark 5000 Denmark Details
SA Pohja-Eesti Regionaalhaigla ( Site 0201) Recruiting Tallinn Harjumaa 13419 Estonia Details
SA Tartu Ulikooli Kliinikum ( Site 0202) Recruiting Tartu Tartumaa 51014 Estonia Details
Institut De Cancerologie De Lorraine ( Site 0222) Recruiting Vandoeuvre les Nancy Ain 54519 France Details
Centre Francois Baclesse ( Site 0236) Recruiting Caen Calvados 14075 France Details
Centre Georges Francois Leclerc ( Site 0223) Recruiting Dijon Cote-d Or 21079 France Details
CHU Limoges Hopital Dupuytren ( Site 0225) Recruiting Limoges Haute-Vienne 87042 France Details
Institut Curie - Centre Rene Huguenin ( Site 0237) Recruiting Saint-Cloud Hauts-de-Seine 92210 France Details
CHU Hotel Dieu Nantes ( Site 0230) Recruiting Nantes Pays-de-la-Loire 44093 France Details
Institut Sainte Catherine ( Site 0228) Recruiting Avignon Provence-Alpes-Cote-d Azur 84918 France Details
CHU Amiens Picardie Site Sud Amiens ( Site 0235) Recruiting Amiens Somme 80054 France Details
CHD Vendee ( Site 0227) Recruiting La Roche sur Yon Vendee 85925 France Details
Marienhospital Stuttgart Vincenz von Paul Kliniken gGmbH ( Site 0253) Recruiting Stuttgart Baden-Wurttemberg 70199 Germany Details
Universitaetsklinikum Koeln ( Site 0251) Recruiting Koeln Nordrhein-Westfalen 50937 Germany Details
Universitaetsklinikum Muenster ( Site 0248) Recruiting Muenster Nordrhein-Westfalen 48149 Germany Details
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz ( Site 0247) Recruiting Mainz Rheinland-Pfalz 55131 Germany Details
Charite Campus Virchow Klinikum ( Site 0250) Recruiting Berlin 13353 Germany Details
Facharztzentrum Eppendorf ( Site 0242) Recruiting Hamburg 20249 Germany Details
Centro de Investigaciones Clinicas de Latinoamerica S.A. - CELAN ( Site 0122) Recruiting Guatemala 01010 Guatemala Details
Gastrosoluciones ( Site 0126) Completed Guatemala 01010 Guatemala Details
Oncomedica ( Site 0125) Recruiting Guatemala 01010 Guatemala Details
Grupo Medico Angeles ( Site 0121) Recruiting Guatemala 01015 Guatemala Details
Medi-K Cayala ( Site 0124) Recruiting Guatemala 01016 Guatemala Details
Centro Medico Integral De Cancerología (CEMIC) ( Site 0123) Recruiting Quetzaltenango 09002 Guatemala Details
Pamela Youde Nethersole Eastern Hospital ( Site 0543) Recruiting Hong Kong Hong Kong Details
Princess Margaret Hospital. ( Site 0542) Recruiting Hong Kong Hong Kong Details
Queen Mary Hospital ( Site 0541) Recruiting Pokfulam Hong Kong Details
Pecsi Tudomanyegyetem AOK ( Site 0265) Recruiting Pecs Baranya 7624 Hungary Details
Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 0262) Completed Gyula Bekes 5700 Hungary Details
Orszagos Onkologiai Intezet ( Site 0263) Recruiting Budapest 1122 Hungary Details
Debreceni Egyetem Klinikai Kozpont ( Site 0261) Recruiting Debrecen 4032 Hungary Details
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 0300) Recruiting Pavia Lombardia 27100 Italy Details
IRCCS Policlinico San Donato ( Site 0295) Completed San Donato Milanese Milano 20097 Italy Details
Azienda Ospedaliero Universitaria Pisana - Presidio Santa Chiara ( Site 0294) Recruiting Pisa Toscana 56126 Italy Details
ASST Papa Giovanni XXIII ( Site 0296) Completed Bergamo 24127 Italy Details
Azienda Socio Sanitaria Territoriale di Cremona ( Site 0299) Recruiting Cremona 26100 Italy Details
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0292) Recruiting Milano 20133 Italy Details
Istituto Nazionale Tumori IRCCS Fondazione Pascale-SC Oncologia Clinica Sperimentale Addome ( Site 0 Recruiting Napoli 80131 Italy Details
IRCCS Istituto Oncologico Veneto ( Site 0298) Recruiting Padova 35128 Italy Details
Policlinico Universitario A. Gemelli ( Site 0297) Recruiting Roma 00168 Italy Details
Aichi Cancer Center Hospital ( Site 0563) Recruiting Nagoya Aichi 464-8681 Japan Details
National Cancer Center Hospital East ( Site 0562) Recruiting Kashiwa Chiba 2778577 Japan Details
Kanagawa Cancer Center ( Site 0565) Recruiting Yokohama Kanagawa 241-8515 Japan Details
Saitama Cancer Center ( Site 0564) Recruiting Kitaadachi-gun Saitama 362-0806 Japan Details
Shizuoka Cancer Center Hospital and Research Institute ( Site 0566) Recruiting Sunto-gun Shizuoka 411-8777 Japan Details
National Cancer Center Hospital ( Site 0561) Recruiting Tokyo 104-0045 Japan Details
Chonnam National University Hwasun Hospital ( Site 0625) Recruiting Hwasun Gun Jeonranamdo 58128 Korea, Republic of Details
National Cancer Center ( Site 0626) Completed Goyang-si Kyonggi-do 10408 Korea, Republic of Details
Asan Medical Center ( Site 0623) Recruiting Songpagu Seoul 05505 Korea, Republic of Details
Severance Hospital Yonsei University Health System ( Site 0624) Recruiting Seoul 03722 Korea, Republic of Details
Samsung Medical Center ( Site 0622) Recruiting Seoul 06351 Korea, Republic of Details
Korea University Guro Hospital ( Site 0621) Recruiting Seoul 08308 Korea, Republic of Details
Instituto Nacional de Enfermedades Neoplasicas ( Site 0141) Completed Lima 15038 Peru Details
Hospital Nacional Arzobispo Loayza ( Site 0143) Recruiting Lima 15082 Peru Details
Clinica San Gabriel ( Site 0142) Completed Lima 15087 Peru Details
Baguio General Hospital and Medical Center ( Site 0603) Recruiting Baguio City Benguet 2600 Philippines Details
Cebu Doctors University Hospital ( Site 0604) Recruiting Cebu City Cebu 6000 Philippines Details
The Medical City-Iloilo ( Site 0602) Recruiting Iloilo City Iloilo 5000 Philippines Details
St. Luke s Medical Center ( Site 0601) Recruiting Quezon National Capital Region 1102 Philippines Details
Hospital Beatriz Angelo ( Site 0374) Recruiting Loures Lisboa 2674-514 Portugal Details
Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 0372) Recruiting Lisboa 1099-023 Portugal Details
CHLN Hospital Santa Maria ( Site 0376) Recruiting Lisboa 1649-035 Portugal Details
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0371) Recruiting Porto 4200-072 Portugal Details
MedEuropa Bucuresti - Centru de Radioterapie-Oncology ( Site 0400) Recruiting București Bucuresti 022343 Romania Details
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 0392) Recruiting Cluj-Napoca Cluj 400015 Romania Details
S.C. Radiotherapy Center Cluj S.R.L ( Site 0391) Recruiting Cluj-Napoca Cluj 407280 Romania Details
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 0394) Recruiting Craiova Dolj 200347 Romania Details
Centrul Medical Topmed ( Site 0398) Recruiting Targu-Mures Mures 540156 Romania Details
S.C.Focus Lab Plus S.R.L ( Site 0395) Recruiting Bucuresti 022548 Romania Details
Spitalul Clinic Judetean De Urgenta Constanta ( Site 0393) Recruiting Constanta 900591 Romania Details
GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 0430) Suspended Ufa Baskortostan, Respublika 450054 Russian Federation Details
Kaluga Regional Clinical Oncology Center ( Site 0424) Suspended Kaluga Kaluzskaja Oblast 248007 Russian Federation Details
Main Military Clinical Hospital n.a. N.N.Burdenko ( Site 0421) Suspended Moscow Moskva 105229 Russian Federation Details
FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 0429) Suspended Moscow Moskva 125367 Russian Federation Details
SBHI Samara Regional Clinical Oncology Dispensary ( Site 0420) Suspended Samara Samarskaya Oblast 443031 Russian Federation Details
Pavlov First Saint Petersburg State Medical University ( Site 0426) Completed St. Petersburg Sankt-Peterburg 197022 Russian Federation Details
Medical institute named after Berezin Sergey ( Site 0417) Suspended St. Petersburg Sankt-Peterburg 197758 Russian Federation Details
Sverdlovsk Regional Oncology Hospital ( Site 0411) Suspended Ekaterinburg Sverdlovskaya Oblast 620036 Russian Federation Details
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0412) Suspended Kazan Tatarstan, Respublika 420029 Russian Federation Details
Chang Gung Med Foundation. Kaohsiung Branch ( Site 0643) Recruiting Kaohsiung 833 Taiwan Details
China Medical University Hospital ( Site 0646) Recruiting Taichung 40447 Taiwan Details
Taichung Veterans General Hospital-Radiation Oncology ( Site 0647) Recruiting Taichung 407 Taiwan Details
National Cheng Kung University Hospital ( Site 0645) Recruiting Tainan 704 Taiwan Details
National Taiwan University Hospital ( Site 0641) Recruiting Taipei 10048 Taiwan Details
Koo Foundation Sun Yat-Sen Cancer Center ( Site 0644) Recruiting Taipei 11259 Taiwan Details
Chang Gung Medical Foundation. Linkou ( Site 0642) Recruiting Taoyuan 33305 Taiwan Details
İstanbul University Cerrahpaşa Medical Faculty ( Site 0452) Recruiting Istambul Istanbul 34098 Turkey Details
Memorial Ankara Hastanesi ( Site 0461) Recruiting Ankara 06520 Turkey Details
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 0451) Recruiting Istanbul 34722 Turkey Details
Ege Universitesi Tip Fakultesi ( Site 0457) Recruiting Izmir 35040 Turkey Details
Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi ( Site 0458) Recruiting Izmir 35360 Turkey Details
Aberdeen Royal Infirmary ( Site 0474) Recruiting Aberdeen Aberdeen City AB25 2ZN United Kingdom Details
Cambridge University Hospitals NHS Trust ( Site 0477) Recruiting Cambridge Cambridgeshire CB2 0QQ United Kingdom Details
Royal Free Hospital ( Site 0702) Recruiting London England NW32QG United Kingdom Details
ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 0283) Recruiting London London, City Of SW3 6JJ United Kingdom Details
Hammersmith Hospital-Medical Oncology ( Site 0471) Recruiting London London, City Of W12 0HS United Kingdom Details
Nottingham University Hospitals NHS Trust ( Site 0476) Recruiting Nottingham Nottinghamshire NG5 1PB United Kingdom Details
Royal Marsden Hospital (Sutton) ( Site 0281) Recruiting Sutton Surrey SM2 5PT United Kingdom Details
University College Hospital NHS Foundation Trust ( Site 0701) Recruiting London Worcestershire NW1 2PG United Kingdom Details
The Christie NHS Foundation Trust ( Site 0282) Recruiting Manchester M20 4BX United Kingdom Details
Mount Vernon Hospital ( Site 0478) Recruiting Northwood HA6 2RN United Kingdom Details
*Shaded cells indicate that there was no data available from clincialtrials.gov for the field