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| NCT ID | NCT04770896 |
| Title | A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab (IMbrave251) |
| Acronym | IMbrave251 |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Medizinische Universität Innsbruck; Universitätsklinik für Innere Medizin I | RECRUITING | Innsbruck | 6020 | Austria | Details | |
| Uniklinikum Salzburg, LKH; Univ.Klinik f. Innere Medizin III der PMU | RECRUITING | Salzburg | 5020 | Austria | Details | |
| Universitätsklinikum St. Pölten; Innere Medizin 2 | RECRUITING | St. Pölten | 3100 | Austria | Details | |
| Klinik Favoriten; Abteilung für Chirurgie | RECRUITING | Wien | 1100 | Austria | Details | |
| Imeldaziekenhuis | ACTIVE_NOT_RECRUITING | Bonheiden | 2820 | Belgium | Details | |
| AZ KLINA | ACTIVE_NOT_RECRUITING | Brasschaat | 2930 | Belgium | Details | |
| Hospital Erasme | ACTIVE_NOT_RECRUITING | Bruxelles | 1070 | Belgium | Details | |
| Cliniques Universitaires St-Luc | ACTIVE_NOT_RECRUITING | Bruxelles | 1200 | Belgium | Details | |
| UZ Gent | WITHDRAWN | Gent | 9000 | Belgium | Details | |
| UZ Leuven | ACTIVE_NOT_RECRUITING | Leuven | 3000 | Belgium | Details | |
| AZ Delta (Campus Rumbeke) | RECRUITING | Roeselare | 8800 | Belgium | Details | |
| Hospital Sao Rafael - HSR | WITHDRAWN | Salvador | BA | 41253-190 | Brazil | Details |
| Sociedade beneficente de senhoras Hospital Sirio Libanes | WITHDRAWN | Brasilia | DF | 70200-730 | Brazil | Details |
| Hospital Felicio Rocho | RECRUITING | Belo Horizonte | MG | 30110-068 | Brazil | Details |
| Clinicas Oncologicas Integradas - COI | RECRUITING | Rio De Janeiro | RJ | 22290-160 | Brazil | Details |
| Hospital Moinhos de Vento | RECRUITING | Porto Alegre | RS | 90035-000 | Brazil | Details |
| Hospital Sao Lucas - PUCRS | RECRUITING | Porto Alegre | RS | 90610-000 | Brazil | Details |
| YNOVA Pesquisa Clinica | RECRUITING | Florianopolis | SC | 88020-210 | Brazil | Details |
| Centro Paulista de Oncologia | WITHDRAWN | Sao Paulo | SP | 04538-132 | Brazil | Details |
| Beneficencia Portuguesa de Sao Paulo | RECRUITING | São Paulo | SP | 01321-00 | Brazil | Details |
| Multiprofile Hospital for Active Treatment Uni Hospital; Department of medicinal oncology | RECRUITING | Panagyurishte | 4500 | Bulgaria | Details | |
| Complex Oncological Center - Plovdiv, EOOD; Second Internal Department | RECRUITING | Plovdiv | 4004 | Bulgaria | Details | |
| MHAT Sveta Sofia; Department of medical oncology | RECRUITING | Sofia | 1618 | Bulgaria | Details | |
| MHAT SofiaMed; OOD | RECRUITING | Sofia | Bulgaria | Details | ||
| SHATOD Dr. Marko Antonov Markov-Varna, EOOD; Department of Medicinall Onchotherapy and Palliative | RECRUITING | Varna | 9010 | Bulgaria | Details | |
| Tom Baker Cancer Centre-Calgary | RECRUITING | Calgary | Alberta | T2N 4N2 | Canada | Details |
| Cross Cancer Institute | RECRUITING | Edmonton | Alberta | T6G 1Z2 | Canada | Details |
| Juravinski Cancer Centre | RECRUITING | Hamilton | Ontario | L8V 5C2 | Canada | Details |
| Princess Margaret Cancer Center | RECRUITING | Toronto | Ontario | M5G 2M9 | Canada | Details |
| Centro de Estudios Clínicos SAGA | RECRUITING | Santiago | 7500653 | Chile | Details | |
| Hospital Clinico de La Universidad de Chile J.J.A.; Oncologia | WITHDRAWN | Santiago | 8380456 | Chile | Details | |
| Pontificia Universidad Catolica de Chile; Clinica San Carlos de Apoquindo | WITHDRAWN | Santiago | Chile | Details | ||
| The Fifth Medical Center of People's Liberation Army General Hospital | RECRUITING | Beijing City | 100039 | China | Details | |
| Peking University People's Hospital | WITHDRAWN | Beijing | 100044 | China | Details | |
| Hunan Cancer Hospital | RECRUITING | Changsha CITY | 410013 | China | Details | |
| West China Hospital - Sichuan University | WITHDRAWN | Chengdu City | 610047 | China | Details | |
| Sichuan Provincial Cancer Hospital | WITHDRAWN | Chengdu | 610041 | China | Details | |
| Fujian Provincial Hospital | COMPLETED | Fuzhou City | 350001 | China | Details | |
| The First Affiliated Hospital, Sun Yat-sen University | ACTIVE_NOT_RECRUITING | Guangzhou City | 510080 | China | Details | |
| Sun Yet-sen University Cancer Center | RECRUITING | Guangzhou City | 510663 | China | Details | |
| Nanfang Hospital, Southern Medical University | RECRUITING | Guangzhou | 510515 | China | Details | |
| Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University | WITHDRAWN | Hangzhou City | 310016 | China | Details | |
| Harbin Medical University Cancer Hospital | ACTIVE_NOT_RECRUITING | Harbin | 150081 | China | Details | |
| Anhui Province Cancer Hospital | ACTIVE_NOT_RECRUITING | Hefei City | 230031 | China | Details | |
| Shandong Provincial Hospital | RECRUITING | Jinan | 250021 | China | Details | |
| Shandong Cancer Hospital | RECRUITING | Jinan | 250117 | China | Details | |
| Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University) | RECRUITING | Nanjing City | 210029 | China | Details | |
| Zhongshan Hospital Fudan University | RECRUITING | Shanghai | 200032 | China | Details | |
| Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | RECRUITING | Shanghai | 200127 | China | Details | |
| Shengjing Hospital of China Medical University | RECRUITING | ShenYang | 110004 | China | Details | |
| Tianjin Cancer Hospital | RECRUITING | Tianjin | 300060 | China | Details | |
| Tongji Hospital Tongji Medical College Huazhong University of Science and Technology | WITHDRAWN | Wuhan City | 430030 | China | Details | |
| Clinica CIMCA | RECRUITING | San José | 10103 | Costa Rica | Details | |
| ICIMED Instituto de Investigación en Ciencias Médicas | ACTIVE_NOT_RECRUITING | San José | 10108 | Costa Rica | Details | |
| Clinical Hospital Centre Zagreb | RECRUITING | Zagreb | 10000 | Croatia | Details | |
| AirForce Specialized Hospital; Clinical Oncology | RECRUITING | Cairo | 11391 | Egypt | Details | |
| North Estonia Medical Centre, Oncology and hematology Clinic; Department of Chemotherapy | RECRUITING | Tallinn | 13419 | Estonia | Details | |
| Tartu University Hospital; Clinic of Hematology and Oncology | RECRUITING | Tartu | 50406 | Estonia | Details | |
| Docrates Cance Center; Docrates | RECRUITING | Helsinki | 00180 | Finland | Details | |
| TAYS Radius rakennus; onkologinen lääketutkimusyksikkö | RECRUITING | Tampere | 33521 | Finland | Details | |
| Turku Uni Central Hospital; Oncology Clinics | RECRUITING | Turku | 20520 | Finland | Details | |
| CHU Grenoble Sud; Service hépato-gastroentérologie | RECRUITING | GRENOBLE Cedex 9 | 38043 | France | Details | |
| CHRU de Lille - Hopital Claude Huriez | ACTIVE_NOT_RECRUITING | Lille | 59037 | France | Details | |
| Aphm; Cpcet | RECRUITING | Marseille | 13385 | France | Details | |
| CH Saint Eloi | RECRUITING | Montpellier | 34295 | France | Details | |
| CHU de Nantes - Hotel Dieu | RECRUITING | Nantes | 44093 | France | Details | |
| CHU Nice - Hôpital de l'Archet 2; service Hepato gastro enterologie | WITHDRAWN | Nice Cedex | 06202 | France | Details | |
| APHP - Hopital Saint Antoine | RECRUITING | Paris | 75571 | France | Details | |
| CHU Bordeaux | ACTIVE_NOT_RECRUITING | Pessac | 33604 | France | Details | |
| Centre Eugene Marquis; Service d'oncologie; Direction de la Recherche Clinique | RECRUITING | Rennes | 35042 | France | Details | |
| CHU de Toulouse - Hôpital Rangueil | RECRUITING | Toulouse Cedex 09 | 31059 | France | Details | |
| Hopitaux de Brabois - Gastro-Entereologie | RECRUITING | Vandoeuvre-les-nancy | 54511 | France | Details | |
| Hopital Paul Brousse; Centre Hepatologie Biliaire | ACTIVE_NOT_RECRUITING | Villejuif | 94804 | France | Details | |
| Klinikum Esslingen; Allg. Innere Med., Onkologie, Hämatologie, Gastroenterologie und Infektiologie | RECRUITING | Esslingen | 73730 | Germany | Details | |
| Klinik Johann Wolfgang von Goethe Uni; Zentrum der Inneren Medizin; Medizinische Klinik I | RECRUITING | Frankfurt | 60590 | Germany | Details | |
| Med. Hochschule Hannover; Gastroenterologie | ACTIVE_NOT_RECRUITING | Hannover | 30625 | Germany | Details | |
| Uniklinik Mainz; I. Medizinische Klinik | ACTIVE_NOT_RECRUITING | Mainz | 55131 | Germany | Details | |
| Universität Tübingen; Med. Klinik; Innere Medizin I | RECRUITING | Tübingen | 72076 | Germany | Details | |
| Universitätsklinikum Ulm; Zentrum für Innere Medizin Klinik für Innere Medizin I | RECRUITING | Ulm | 89081 | Germany | Details | |
| Laiko General Hospital Athen; Uni Clinic of Gastrenterology | RECRUITING | Athens | 115 27 | Greece | Details | |
| Agioi Anargiroi Hospital of Kifissia; University Internal Medicine Clinic | RECRUITING | Nea Kifissia | 14564 | Greece | Details | |
| Anticancer Hospital of Thessaloniki " Theagenio" | RECRUITING | Thessaloniki | 54007 | Greece | Details | |
| Hippokratio Hospital; 4Th Internal Medicine Dpt | RECRUITING | Thessaloniki | 546 42 | Greece | Details | |
| HealthCare Global Enterprises Limited; Medical Oncology | RECRUITING | Banglore | Karnataka | 560027 | India | Details |
| Tata Memorial Hospital; Dept of Medical Oncology | RECRUITING | Mumbai | Maharashtra | 400012 | India | Details |
| Rambam Health Care Campus; Oncology | RECRUITING | Haifa | 3109601 | Israel | Details | |
| Rabin Medical Center; Oncology Dept | RECRUITING | Petah Tikva | 4910000 | Israel | Details | |
| Sourasky Medical Center; Oncology Department | RECRUITING | Tel-Aviv | 6423900 | Israel | Details | |
| Fondazione Pascale; U.O. Sperimentazioni Cliniche | RECRUITING | Napoli | Campania | 80100 | Italy | Details |
| Azienda Osp Uni Seconda Università Degli Studi Di Napoli; Unità Operativa Oncologia Medica | RECRUITING | Napoli | Campania | 80131 | Italy | Details |
| Ospedale del Mare; UOC di Oncologia | COMPLETED | Napoli | Campania | 80147 | Italy | Details |
| A.O. S. Orsola Malpighi; Ambulatorio Epatocarcinoma (Bolondi) | ACTIVE_NOT_RECRUITING | Bologna | Emilia-Romagna | 40138 | Italy | Details |
| Azienda Ospedaliera San Camillo Forlanini | RECRUITING | Roma | Lazio | 151 | Italy | Details |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | RECRUITING | Rome | Lazio | 00168 | Italy | Details |
| Fondazione IRCCS Ospedale Maggiore Policlinico; Gastroenterologia | ACTIVE_NOT_RECRUITING | Milano | Lombardia | 20122 | Italy | Details |
| Azienda Ospedaliera Ordine Mauriziano di Torino | RECRUITING | Torino | Piemonte | 10128 | Italy | Details |
| A.O.U. Policlinico Paolo Giaccone; Gastroenterologia ed Epatologia | RECRUITING | Palermo | Sicilia | 90100 | Italy | Details |
| Azienda Ospedaliero-Universitaria Careggi;S.C. Oncologia Medica 1 | RECRUITING | Firenze | Toscana | 50139 | Italy | Details |
| Azlenda Ospendaliero-Universitaria Pisana; C.O. Oncologia 2 | RECRUITING | Pisa | Toscana | 56100 | Italy | Details |
| IRCCS Istituto Oncologico Veneto (IOV); Oncologia Medica Seconda | ACTIVE_NOT_RECRUITING | Padova | Veneto | 35128 | Italy | Details |
| Fujita Health University Hospital | RECRUITING | Aichi | 470-1192 | Japan | Details | |
| Chiba University Hospital | RECRUITING | Chiba | 260-8677 | Japan | Details | |
| National Cancer Center Hospital East | RECRUITING | Chiba | 277-8577 | Japan | Details | |
| Kurume University Hospital | ACTIVE_NOT_RECRUITING | Fukuoka | 830-0011 | Japan | Details | |
| Hiroshima University Hospital | ACTIVE_NOT_RECRUITING | Hiroshima | 734-8551 | Japan | Details | |
| Japanese Red Cross Society Himeji Hospital | RECRUITING | Hyogo | 670-8540 | Japan | Details | |
| Yokohama City University Medical Center | RECRUITING | Kanagawa | 232-0024 | Japan | Details | |
| Osaka University Hospital | RECRUITING | Osaka | 565-0871 | Japan | Details | |
| Kindai University Hospital | RECRUITING | Osaka | 589-8511 | Japan | Details | |
| Jichi Medical University Hospital | RECRUITING | Tochigi | 329-0498 | Japan | Details | |
| Toranomon Hospital | RECRUITING | Tokyo | 105-8470 | Japan | Details | |
| Japanese Red Cross Musashino Hospital | RECRUITING | Tokyo | 180-8610 | Japan | Details | |
| National Cancer Center | ACTIVE_NOT_RECRUITING | Goyang-si | 10408 | Korea, Republic of | Details | |
| CHA Bundang Medical Center | ACTIVE_NOT_RECRUITING | Gyeonggi-do | 13496 | Korea, Republic of | Details | |
| Severance Hospital, Yonsei University Health System | ACTIVE_NOT_RECRUITING | Seoul | 03722 | Korea, Republic of | Details | |
| Samsung Medical Center | ACTIVE_NOT_RECRUITING | Seoul | 06351 | Korea, Republic of | Details | |
| Uni Malaya Medical Center; Clinical Oncology Unit, Menara Timur | RECRUITING | Kuala Lumpur | FED. Territory OF Kuala Lumpur | 59100 | Malaysia | Details |
| Institute Kanser Negara (IKN) | COMPLETED | Putrajaya | FED. Territory OF Kuala Lumpur | 62250 | Malaysia | Details |
| Beacon International Specialist Centre; Clinical Research Department, Level 2 | COMPLETED | Petaling Jaya, Selangor | Selangor | 46050 | Malaysia | Details |
| Cebu Doctors' University Hospital; Research Office | RECRUITING | Cebu City | 6000 | Philippines | Details | |
| Makati Medical Center | RECRUITING | Makati City | 1229 | Philippines | Details | |
| The Medical City; Cancer Center | RECRUITING | Pasig City | 1600 | Philippines | Details | |
| Chelyabinsk Regional Clinical Oncology Dispensary | WITHDRAWN | Chelyabinsk | Moskovskaja Oblast | 454087 | Russian Federation | Details |
| FSBI "National Medical Research Center of Oncology N.N. Blokhin? | RECRUITING | Moscow | Moskovskaja Oblast | 115478 | Russian Federation | Details |
| Moscow City Oncology Hospital #62; Outpatient Care Center | RECRUITING | Moscow | Moskovskaja Oblast | 125134 | Russian Federation | Details |
| Group of companies "Medci" | RECRUITING | Moskva | Moskovskaja Oblast | 105229 | Russian Federation | Details |
| I.M.Sechenov First Moscow State Medical University (1st MSMU) | RECRUITING | Moskva | Moskovskaja Oblast | 119991 | Russian Federation | Details |
| Clinical Hospital Lapino (LLC Haven) | WITHDRAWN | Yudino | Moskovskaja Oblast | 143081 | Russian Federation | Details |
| LLC "Oncology scientific centre" | RECRUITING | Pesochny | Sankt Petersburg | 197758 | Russian Federation | Details |
| University Medical Center Ljubljana; Clinical Dept. of Gastroenterology | RECRUITING | Ljubljana | 1000 | Slovenia | Details | |
| Corporacio Sanitaria Parc Tauli; Servicio de Hepatologia | RECRUITING | Sabadell | Barcelona | 08208 | Spain | Details |
| Hospital Son Llatzer; Servicio de Oncologia | RECRUITING | Palma de Mallorca | Islas Baleares | 07198 | Spain | Details |
| Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia | ACTIVE_NOT_RECRUITING | Santiago de Compostela | LA Coruña | 15706 | Spain | Details |
| Clinica Universitaria de Navarra; Servicio de Hepatologia | RECRUITING | Pamplona/iruña | Navarra | 31008 | Spain | Details |
| Hospital Universitari Vall d'Hebron; Servicio de Hepatologia | RECRUITING | Barcelona | 08035 | Spain | Details | |
| Hospital Universitario Reina Sofia; Servicio de Hepatologia | RECRUITING | Cordoba | 14004 | Spain | Details | |
| Hospital General Universitario Gregorio Marañon; Servicio de Aparato Digestivo | RECRUITING | Madrid | 28007 | Spain | Details | |
| Clinica Universidad de Navarra Madrid; Servicio de Oncología | RECRUITING | Madrid | 28027 | Spain | Details | |
| Hospital Clinico San Carlos; Servicio de Oncologia | RECRUITING | Madrid | 28040 | Spain | Details | |
| START Madrid. Centro Integral Oncologico Clara Campal; CIOCC | RECRUITING | Madrid | 28050 | Spain | Details | |
| Hospital Universitario la Fe; Servicio de Oncologia | RECRUITING | Valencia | 46026 | Spain | Details | |
| Hospital Universitario Miguel Servet; Servicio Oncologia | RECRUITING | Zaragoza | 50009 | Spain | Details | |
| Inselspital Bern Medizin Gastroenterologie | RECRUITING | Bern | 3010 | Switzerland | Details | |
| Universitätsspital Zürich Medizin Gastroenterologie; Klinik für Gastroenterologie und Hepatologie | RECRUITING | Zürich | 8091 | Switzerland | Details | |
| Chi-Mei Medical Centre; Hematology & Oncology | RECRUITING | Tainan | 710 | Taiwan | Details | |
| National Taiwan University Hospital; Oncology | ACTIVE_NOT_RECRUITING | Zhongzheng Dist. | 10048 | Taiwan | Details | |
| Chulalongkorn Hospital; Medical Oncology | ACTIVE_NOT_RECRUITING | Bangkok | 10330 | Thailand | Details | |
| Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology | RECRUITING | Bangkok | 10700 | Thailand | Details | |
| Adana Ac?badem Hospital Oncology Department | ACTIVE_NOT_RECRUITING | Adana | 01130 | Turkey | Details | |
| Memorial Ankara Hastanesi | ACTIVE_NOT_RECRUITING | Ankara | 06520 | Turkey | Details | |
| Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji | RECRUITING | Bakirkoy / Istanbul | 34147 | Turkey | Details | |
| Uludag Uni Hospital; Oncology | RECRUITING | Bursa | 16059 | Turkey | Details | |
| Medipol Mega Üniversite Hastanesi Göztepe | RECRUITING | Istanbul | 34214 | Turkey | Details | |
| Ege Uni Medical Faculty Hospital; Oncology Dept | ACTIVE_NOT_RECRUITING | Izmir | 35100 | Turkey | Details | |
| Hacettepe Uni Medical Faculty Hospital; Oncology Dept | RECRUITING | Sihhiye/Ankara | 06230 | Turkey | Details | |
| Ac?badem Altunizade Hastanesi; Oncology | RECRUITING | Üsküdar | 34662 | Turkey | Details | |
| Queen Elizabeth Hospital; Hepatobiliary Unit | RECRUITING | Birmingham | B15 2TH | United Kingdom | Details | |
| The Clatterbridge Cancer Centre NHS Foundation Trust | ACTIVE_NOT_RECRUITING | Liverpool | L7 8YA | United Kingdom | Details | |
| Royal Free Hospital | ACTIVE_NOT_RECRUITING | London | NW3 2QS | United Kingdom | Details | |
| King College Hospital NHS Foundation Trust | ACTIVE_NOT_RECRUITING | London | SE5 9RS | United Kingdom | Details | |
| Hammersmith Hospital; Clinical trials unit | RECRUITING | London | W12 0HS | United Kingdom | Details | |
| Christie Hospital Nhs Trust; Medical Oncology | RECRUITING | Manchester | M2O 4BX | United Kingdom | Details | |
| Freeman Hospital; Gastroenterology & Liver Unit | RECRUITING | Newcastle Upon Tyne | NE7 7DN | United Kingdom | Details | |
| Churchill Hospital; Department of Oncology | RECRUITING | Oxford | OX3 7LE | United Kingdom | Details |