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NCT ID NCT04895358
Title Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)
Recruitment Recruiting
Gender both
Phase Phase III
Variant Requirements No
Sponsors Merck Sharp & Dohme Corp.

Her2-receptor negative breast cancer



Nab-paclitaxel + Pembrolizumab

Capecitabine + Pembrolizumab

Paclitaxel + Pembrolizumab


Daunoxome + Pembrolizumab



Age Groups: adult | senior
Covered Countries USA | ITA | FRA | ESP | DEU | CAN | AUT

Facility Status City State Zip Country Details
Arizona Oncology Associates-Arizona Oncology ( Site 0049) Recruiting Tucson Arizona 85711 United States Details
Pacific Cancer Care ( Site 0023) Recruiting Monterey California 93940 United States Details
UCSF Medical Center at Mission Bay ( Site 0043) Recruiting San Francisco California 94158 United States Details
Georgetown University Medical Center-Department of Medicine and Oncology ( Site 0026) Recruiting Washington District of Columbia 20007 United States Details
MedStar Washington Hospital Center ( Site 0063) Recruiting Washington District of Columbia 20010 United States Details
Baptist MD Anderson Cancer Center ( Site 0013) Recruiting Jacksonville Florida 32207 United States Details
University Cancer & Blood Center, LLC ( Site 0032) Recruiting Athens Georgia 30607 United States Details
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0028) Recruiting Marietta Georgia 30060 United States Details
University of Illinois at Chicago ( Site 0061) Recruiting Chicago Illinois 60612 United States Details
Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0067) Recruiting Elmhurst Illinois 60126 United States Details
Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0066) Recruiting Naperville Illinois 60540 United States Details
Edward-Elmhurst Healthcare, Edward Hospital - Plainfield-Edward Cancer Center - Plainfield ( Site 00 Recruiting Plainfield Illinois 60585 United States Details
Orchard Healthcare Research Inc. ( Site 0037) Recruiting Skokie Illinois 60077 United States Details
McFarland Clinic, PC ( Site 0041) Recruiting Ames Iowa 50010 United States Details
New England Cancer Specialists ( Site 0007) Recruiting Scarborough Maine 04074 United States Details
Greater Baltimore Medical Center-Medical Oncology/Hematology ( Site 0062) Recruiting Baltimore Maryland 21204 United States Details
MFSMC-HJWCI ( Site 0064) Recruiting Baltimore Maryland 21237 United States Details
University of Massachusetts Medical School-Division of Hematology/Oncology ( Site 0052) Recruiting Worcester Massachusetts 01655 United States Details
Henry Ford Hospital ( Site 0003) Recruiting Detroit Michigan 48202 United States Details
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0009) Recruiting Omaha Nebraska 68130 United States Details
Broome Oncology ( Site 0018) Recruiting Johnson City New York 13790 United States Details
Hematology Oncology Associates of Rockland ( Site 0044) Recruiting Nyack New York 10960 United States Details
Waverly Hematology Oncology ( Site 0015) Completed Cary North Carolina 27518 United States Details
Sanford Fargo Medical Center ( Site 0040) Recruiting Fargo North Dakota 58102 United States Details
Providence Portland Medical Center ( Site 0038) Recruiting Portland Oregon 97213 United States Details
St Francis Cancer Center ( Site 0058) Recruiting Greenville South Carolina 29607 United States Details
Sanford Cancer Center ( Site 0021) Recruiting Sioux Falls South Dakota 57104 United States Details
University of Tennessee Medical Center ( Site 0039) Recruiting Knoxville Tennessee 37920 United States Details
Bon Secours St. Francis Medical Center-Oncology Research ( Site 0020) Recruiting Midlothian Virginia 23114 United States Details
Kadlec Clinic Hematology and Oncology ( Site 0055) Recruiting Kennewick Washington 99336 United States Details
Medical Oncology Associates, PS ( Site 0010) Recruiting Spokane Washington 99208 United States Details
Northwest Medical Specialties, PLLC ( Site 0008) Recruiting Tacoma Washington 98405 United States Details
North Star Lodge ( Site 0035) Recruiting Yakima Washington 98902 United States Details
Centro de Oncología e Investigación de Buenos Aires ( Site 0400) Recruiting Berazategui Buenos Aires B1884BBF Argentina Details
Hospital Británico de Buenos Aires-Oncology ( Site 0404) Recruiting Ciudad autónoma de Buenos Aires Buenos Aires 1280 Argentina Details
Hospital Aleman-Oncology ( Site 0402) Recruiting Buenos Aires Caba C1118AAT Argentina Details
Instituto de Oncología de Rosario ( Site 0401) Recruiting Rosario Santa Fe S2000KZE Argentina Details
Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0403) Recruiting Buenos Aires 1431 Argentina Details
Macquarie University-MQ Health Clinical Trials Unit ( Site 2102) Recruiting Macquarie Park New South Wales 2109 Australia Details
Westmead Hospital-Department of Medical Oncology ( Site 2101) Recruiting Westmead New South Wales 2145 Australia Details
Frankston Hospital-Oncology and Haematology ( Site 2103) Recruiting Frankston Victoria 3199 Australia Details
Breast Cancer Research Centre-WA ( Site 2104) Recruiting Nedlands Western Australia 6009 Australia Details
Medizinische Universität Graz-Innere Medizin Klin. Abt. Onkologie ( Site 1609) Recruiting Graz Steiermark 8036 Austria Details
Medizinische Universitaet Innsbruck ( Site 1602) Recruiting Innsbruck Tirol 6020 Austria Details
Medizinische Universität Wien ( Site 1601) Recruiting Vienna Wien 1090 Austria Details
Uniklinikum Salzburg-Universitätsklinik für Innere Medizin III der PMU mit Hämatologie, internistis Recruiting Salzburg 5020 Austria Details
Tom Baker Cancer Center ( Site 0107) Recruiting Calgary Alberta T2N 4N2 Canada Details
North York General Hospital ( Site 0108) Recruiting Toronto Ontario M2K1E1 Canada Details
Princess Margaret Cancer Centre ( Site 0101) Recruiting Toronto Ontario M5G 2M9 Canada Details
Jewish General Hospital ( Site 0110) Recruiting Montreal Quebec H3T 1E2 Canada Details
Centre Hospitalier de l'Université de Montréal ( Site 0105) Recruiting Montréal Quebec H2X 3E4 Canada Details
Hopital Du Saint-Sacrement ( Site 0109) Recruiting Quebec City Quebec G1S 4L8 Canada Details
Centro Investigación del Cáncer James Lind ( Site 0513) Recruiting Temuco Araucania Temuco Chile Details
FALP ( Site 0501) Recruiting Santiago Region M. De Santiago 6900941 Chile Details
Oncovida ( Site 0514) Recruiting Santiago Region M. De Santiago 7510032 Chile Details
Instituto Nacional del Cancer-CR Investigación ( Site 0511) Recruiting Santiago Region M. De Santiago 8380455 Chile Details
Bradfordhill ( Site 0500) Recruiting Santiago Region M. De Santiago 8420383 Chile Details
Beijing Cancer hospital-Department of Breast Cancer ( Site 2605) Recruiting Beijing Beijing 100142 China Details
Beijing Peking Union Medical College Hospital-Medical Oncology ( Site 2610) Recruiting Beijing Beijing 100730 China Details
SUN YAT-SEN UNIVERSITY CANCER CENTRE-oncology breast ( Site 2616) Recruiting Guangzhou Guangdong 510060 China Details
Peking University Shenzhen Hospital-Oncology Department ( Site 2601) Recruiting Shenzhen Guangdong 518036 China Details
Henan Cancer Hospital-Galactophore Department ( Site 2615) Recruiting Zhengzhou Henan 450008 China Details
Wuhan Union Hospital Cancer Center-Cancer Center ( Site 2629) Recruiting Wuhan Hubei 430022 China Details
Jiangsu provincial people's hospital-Oncology Department ( Site 2607) Recruiting Nanjing Jiangsu 210029 China Details
The Third Hospital of Nanchang-Oncology Dept ( Site 2628) Recruiting Nanchang Jiangxi 330009 China Details
Jilin Cancer Hospital-oncology department ( Site 2619) Recruiting Changchun Jilin 130000 China Details
Shandong Cancer Hospital-Breast surgery ( Site 2623) Recruiting Jinan Shandong 250000 China Details
Fudan University Shanghai Cancer Center-Oncology ( Site 2600) Recruiting Shanghai Shanghai 200032 China Details
Renji Hospital Shanghai Jiao Tong University School of Medicine-Breast surgery ( Site 2626) Recruiting Shanghai Shanghai 200120 China Details
Tianjin Medical University Cancer Institute and Hospital-Department of Breast Cancer ( Site 2612) Recruiting Tianjin Tianjin 300060 China Details
Xinjiang Medical University Cancer Hospital - Urumqi-galactophore department ( Site 2624) Recruiting Urumqi Xinjiang 830000 China Details
Zhejiang Cancer Hospital-Breast Oncology ( Site 2622) Recruiting Hangzhou Zhejiang 310022 China Details
The First Affiliated Hospital of Wenzhou Medical University-Thyroid and breast surgery ( Site 2625) Recruiting Wenzhou Zhejiang 32500 China Details
Institut Paoli-Calmettes ( Site 0913) Recruiting Marseille Bouches-du-Rhone 13009 France Details
Centre François Baclesse ( Site 0920) Recruiting Caen Calvados 14076 France Details
Institut Claudius Regaud ( Site 0902) Recruiting Toulouse Haute-Garonne 31059 France Details
Centre de Cancérologie du Grand Montpellier ( Site 0912) Recruiting Montpellier Languedoc-Roussillon 34070 France Details
Institut de Cancérologie de l'Ouest ( Site 0907) Recruiting Saint Herblain Loire-Atlantique 44805 France Details
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0901) Recruiting Clermont-Ferrand Puy-de-Dome 63011 France Details
CENTRE LEON BERARD ( Site 0919) Recruiting Lyon Rhone-Alpes 69008 France Details
Gynaekologisches Zentrum Bonn ( Site 1201) Recruiting Bonn Nordrhein-Westfalen 53111 Germany Details
Universitaetsklinikum Duesseldorf-Klinik für Frauenheilkunde & Geburtshilfe ( Site 1204) Recruiting Düsseldorf Nordrhein-Westfalen 40225 Germany Details
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinike für Senologie/ Brustzentrum ( Site 1200 Recruiting Essen Nordrhein-Westfalen 45136 Germany Details
Vivantes Klinikum Am Urban-Haematologie und Onkologie ( Site 1203) Recruiting Berlin 10967 Germany Details
Alexandra Hospital-ONCOLGOY DEPT. ( Site 0302) Recruiting Athens Attiki 115 28 Greece Details
Hygeia Hospital-3rd Oncology Department ( Site 0304) Recruiting Marousi Attiki 151 23 Greece Details
University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 0303) Recruiting Heraklion Irakleio 711 10 Greece Details
CELAN,S.A ( Site 0151) Recruiting Guatemala 01010 Guatemala Details
Gastrosoluciones ( Site 0156) Recruiting Guatemala 01010 Guatemala Details
INTEGRA Cancer Institute ( Site 0155) Recruiting Guatemala 01010 Guatemala Details
Centro Medico Integral De Cancerología (CEMIC) ( Site 0154) Recruiting Quetzaltenango 09002 Guatemala Details
St. Vincent's University Hospital-Medical Oncology Research Department ( Site 1531) Recruiting Dublin D4 YN63 Ireland Details
Assuta Ashdod Medical Center ( Site 1703) Recruiting Ashdod 7747629 Israel Details
Soroka Medical Center-Oncology ( Site 1702) Recruiting Be'er Sheva 8400000 Israel Details
Sheba Medical Center-ONCOLOGY ( Site 1700) Recruiting Ramat Gan 5265601 Israel Details
Sourasky Medical Center-Oncology ( Site 1701) Recruiting Tel Aviv 6423906 Israel Details
Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1114) Recruiting Rozzano Milano 20089 Italy Details
Ospedale San Raffaele-Oncologia Medica ( Site 1110) Recruiting Milano 20132 Italy Details
Istituto Europeo di Oncologia IRCCS-Divisione di Senologia Medica ( Site 1111) Recruiting Milano 20141 Italy Details
Fondazione Policlinico Universitario Agostino Gemelli-Medical Oncology ( Site 1113) Recruiting Roma 00168 Italy Details
Hyogo College of Medicine ( Site 2201) Recruiting Nishinomiya Hyogo 663-8501 Japan Details
St. Marianna University School of Medicine Hospital ( Site 2205) Recruiting Kawasaki Kanagawa 216-8511 Japan Details
Kitasato University Hospital ( Site 2204) Recruiting Sagamihara Kanagawa 252-0375 Japan Details
Saitama Medical University International Medical Center ( Site 2208) Recruiting Hidaka-city Saitama 350-1298 Japan Details
Tokyo Medical University Hospital ( Site 2206) Recruiting Shinjuku-ku Tokyo 160-0023 Japan Details
National Hospital Organization Kyushu Cancer Center ( Site 2209) Recruiting Fukuoka 811-1395 Japan Details
Fukushima Medical University ( Site 2200) Recruiting Fukushima 9601101 Japan Details
Kumamoto University ( Site 2203) Recruiting Kumamoto 860-8556 Japan Details
St. Luke's International Hospital ( Site 2207) Recruiting Tokyo 104-8560 Japan Details
Juntendo University Hospital ( Site 2210) Recruiting Tokyo 113-8431 Japan Details
National Cancer Center-Center for Breast Cancer ( Site 2404) Recruiting Goyang-si Kyonggi-do 10408 Korea, Republic of Details
Seoul National University Bundang Hospital ( Site 2406) Recruiting Seongnam Kyonggi-do 13620 Korea, Republic of Details
Seoul National University Hospital-Internal Medicine ( Site 2403) Recruiting Seoul 03080 Korea, Republic of Details
Severance Hospital, Yonsei University Health System ( Site 2400) Recruiting Seoul 03722 Korea, Republic of Details
Asan Medical Center ( Site 2402) Recruiting Seoul 05505 Korea, Republic of Details
Samsung Medical Center-Division of Hematology/Oncology ( Site 2401) Recruiting Seoul 06351 Korea, Republic of Details
University Malaya Medical Centre ( Site 2505) Recruiting Lembah Pantai Kuala Lumpur 59100 Malaysia Details
Hospital Pulau Pinang ( Site 2504) Recruiting George Town Pulau Pinang 10990 Malaysia Details
Sarawak General Hospital-Radiotherapy Unit ( Site 2501) Recruiting Kuching Sarawak 93586 Malaysia Details
Pantai Hospital Kuala Lumpur-Cancer Centre ( Site 2503) Recruiting Kuala Lumpur 59100 Malaysia Details
Samadhi Centro Oncológico ( Site 0258) Recruiting México Distrito Federal 04739 Mexico Details
Hospital Civil Fray Antonio Alcalde-Oncology ( Site 0262) Recruiting Guadalajara Jalisco 44280 Mexico Details
Christus Muguerza Clinica Vidriera ( Site 0253) Recruiting Monterrey Nuevo Leon 64570 Mexico Details
Centro Estatal de Cancerologia-Investigación ( Site 0256) Recruiting Chihuahua 31000 Mexico Details
Centro de Investigacion Clinica de Oaxaca ( Site 0252) Recruiting Oaxaca 68020 Mexico Details
Maastricht UMC+-Medical Oncology ( Site 1353) Recruiting Maastricht Limburg 6229 HX Netherlands Details
Elisabeth-TweeSteden Ziekenhuis-Internal Medicine ( Site 1357) Recruiting Tilburg Noord-Brabant 5022 GC Netherlands Details
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL) ( Site 1351) Recruiting Amsterdam Noord-Holland 1066 CX Netherlands Details
Leids Universitair Medisch Centrum-Medical Oncology ( Site 1356) Recruiting Leiden Zuid-Holland 2333 ZA Netherlands Details
Haaglanden MC - locatie Antoniushove-Medical oncology ( Site 1355) Recruiting Leidschendam Zuid-Holland 2501 ck Netherlands Details
East Avenue Medical Center ( Site 0802) Recruiting Quezon City National Capital Region 1500 Philippines Details
CARDINAL SANTOS MEDICAL CENTER-Research Room ( Site 0800) Recruiting San Juan National Capital Region 1502 Philippines Details
Centrum Medyczne Ostrobramska NZOZ Magodent ( Site 1808) Recruiting Warsaw Mazowieckie 04-125 Poland Details
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Piersi i Chirurgii ( Recruiting Warszawa Mazowieckie 02-781 Poland Details
Bialostockie Centrum Onkologii-Oddzial Onkologii Klinicznej ( Site 1812) Recruiting Bialystok Podlaskie 15-027 Poland Details
Champalimaud Foundation ( Site 1006) Recruiting Lisbon Lisboa 1400-038 Portugal Details
Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria ( Site 1004) Recruiting Lisbon Lisboa 1649-035 Portugal Details
Centro Hospitalar do Porto - Hospital de Santo António-Oncology Service ( Site 1003) Recruiting Porto 4099-001 Portugal Details
Arkhangelsk Clinical Oncological Dispensary-Chemotherapy department ( Site 1902) Suspended Arkhangelsk Arkhangel Skaya Oblast 163045 Russian Federation Details
Podolsk Regional Clinical Hospital ( Site 1907) Suspended Podolsk Moskovskaya Oblast 142110 Russian Federation Details
Moscow Clinical Research Center-Chemotherapy department ( Site 1903) Suspended Moscow Moskva 111123 Russian Federation Details
Fed State Budgetary Inst N.N. Blokhin Med Center of Oncology MHRF ( Site 1901) Suspended Moscow Moskva 115478 Russian Federation Details
Central Clinical Hospital of the Presidential Administrative Department ( Site 1904) Suspended Moscow Moskva 121359 Russian Federation Details
Nizhegorodsky Regional Oncology Dispensary-chemotherapy ( Site 1912) Suspended Nizhniy Novgorod Nizhegorodskaya Oblast 603081 Russian Federation Details
Ryazan Regional Clinical Oncology Center-Oncology #1 ( Site 1906) Suspended Ryazan Ryazanskaya Oblast 390005 Russian Federation Details
N.N.Petrov Research Institute of Oncology ( Site 1900) Completed Saint Petersburg Sankt-Peterburg 197758 Russian Federation Details
St. Petersburg Clinical Hospital of Russian Academy Of Sciences-Medical Oncology ( Site 1905) Suspended St. Petersburg Sankt-Peterburg 194017 Russian Federation Details
Hospital Quiron Barcelona ( Site 1326) Recruiting Barcelona Cataluna 08023 Spain Details
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1320) Recruiting Madrid Madrid, Comunidad De 28034 Spain Details
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 1323) Recruiting Pozuelo de Alarcon Madrid 28223 Spain Details
Fundación Instituto Valenciano de Oncología-Oncologico ( Site 1332) Recruiting Valencia Valenciana, Comunitat 46009 Spain Details
HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 1333) Recruiting Madrid 28007 Spain Details
Karolinska Universitetssjukhuset Solna-Tema Cancer - ME Bröst- endokrina tumörer och sarkom ( Site 1 Recruiting Stockholm Stockholms Lan 171 76 Sweden Details
Södra Älvsborg Sjukhus ( Site 1406) Recruiting Borås Vastra Gotalands Lan 501 82 Sweden Details
Baskent University Dr. Turgut Noyan Research and Training Center ( Site 2013) Recruiting Adana 01250 Turkey Details
Hacettepe Universitesi-oncology hospital ( Site 2000) Recruiting Ankara 06230 Turkey Details
Memorial Ankara Hastanesi-Medical Oncology ( Site 2002) Recruiting Ankara 06520 Turkey Details
Gazi Universitesi-Oncology ( Site 2010) Recruiting Ankara 06560 Turkey Details
Akdeniz Universitesi Hastanesi-Medical Oncology ( Site 2009) Recruiting Antalya 07059 Turkey Details
Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 2012) Recruiting Istanbul 34668 Turkey Details
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2005) Recruiting Istanbul 34722 Turkey Details
St Bartholomew's Hospital ( Site 1508) Recruiting London England EC1A 7BE United Kingdom Details
The Royal Cornwall Hospital ( Site 1507) Recruiting Truro England TR1 3LJ United Kingdom Details
Blackpool Victoria Hospital ( Site 1503) Recruiting Blackpool Lancashire FY3 8NR United Kingdom Details
Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 1502) Recruiting Leicester Leicestershire LE1 5WW United Kingdom Details
The Christie ( Site 1510) Recruiting Manchester M20 4BX United Kingdom Details
*Shaded cells indicate that there was no data available from for the field