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| NCT ID | NCT04965493 |
| Title | A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (BRUIN CLL-322) |
| Acronym | BRUIN CLL-322 |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Loxo Oncology, Inc. |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Mayo Clinic Arizona | RECRUITING | Phoenix | Arizona | 85054 | United States | Details |
| University of Arizona Cancer Center | RECRUITING | Tucson | Arizona | 85724 | United States | Details |
| University of California Irvine Medical Center | RECRUITING | Orange | California | 92868 | United States | Details |
| Scripps Mercy Hospital | RECRUITING | San Diego | California | 92103 | United States | Details |
| Sharp Memorial Hospital | RECRUITING | San Diego | California | 92123 | United States | Details |
| Providence Medical Foundation | RECRUITING | Santa Rosa | California | 95403 | United States | Details |
| Hematology Oncology, P.C. | RECRUITING | Stamford | Connecticut | 06904 | United States | Details |
| Florida Cancer Specialists-Broadway | RECRUITING | Fort Myers | Florida | 33916 | United States | Details |
| Cancer Specialists, LLC | RECRUITING | Jacksonville | Florida | 32256 | United States | Details |
| Florida Cancer Specialists North | RECRUITING | Saint Petersburg | Florida | 33705 | United States | Details |
| Florida Cancer Specialists Panhandle | RECRUITING | Tallahassee | Florida | 32308 | United States | Details |
| Florida Cancer Specialists East | RECRUITING | West Palm Beach | Florida | 33401 | United States | Details |
| Carle Clinic Association, P.C. | RECRUITING | Urbana | Illinois | 61801 | United States | Details |
| Central Care Cancer Center | RECRUITING | Garden City | Kansas | 67846 | United States | Details |
| Pikeville Medical Center, Inc. | RECRUITING | Pikeville | Kentucky | 41501 | United States | Details |
| Hematology Oncology Clinic | RECRUITING | Baton Rouge | Louisiana | 70809 | United States | Details |
| American Oncology Partners of Maryland, PA | RECRUITING | Bethesda | Maryland | 20817 | United States | Details |
| Dana-Farber Cancer Institute | RECRUITING | Boston | Massachusetts | 02215 | United States | Details |
| University of Michigan | RECRUITING | Ann Arbor | Michigan | 48109 | United States | Details |
| Karmanos Cancer Institute | RECRUITING | Detroit | Michigan | 48201 | United States | Details |
| Mayo Clinic- Rochester | RECRUITING | Rochester | Minnesota | 55905 | United States | Details |
| Central Care Cancer Center | RECRUITING | Bolivar | Missouri | 65613 | United States | Details |
| Sarah Cannon Research Institute SCRI | RECRUITING | Kansas City | Missouri | 63142 | United States | Details |
| Memorial Sloan Kettering Cancer Center | RECRUITING | Basking Ridge | New Jersey | 07920 | United States | Details |
| Hackensack University Medical Center | RECRUITING | Hackensack | New Jersey | 07601 | United States | Details |
| Memorial Sloan Kettering Cancer Center | RECRUITING | Middletown | New Jersey | 07748 | United States | Details |
| Memorial Sloan Kettering Cancer Center | RECRUITING | Montvale | New Jersey | 07645 | United States | Details |
| Carol G Simon Cancer Center | RECRUITING | Morristown | New Jersey | 07962 | United States | Details |
| Memorial Sloan Kettering Cancer Center | RECRUITING | Commack | New York | 11725 | United States | Details |
| Memorial Sloan Kettering Cancer Center | RECRUITING | Harrison | New York | 10604 | United States | Details |
| Columbia University Medical Center | RECRUITING | New York | New York | 10032 | United States | Details |
| Memorial Sloan Kettering Cancer Center | RECRUITING | New York | New York | 10065 | United States | Details |
| Icahn School of Medicine at Mount Sinai | RECRUITING | New York | New York | 10128 | United States | Details |
| Westchester Medical College | RECRUITING | New York | New York | 10532 | United States | Details |
| SUNY Upstate Medical Center | RECRUITING | Syracuse | New York | 13210 | United States | Details |
| Memorial Sloan Kettering Cancer Center | RECRUITING | Uniondale | New York | 11553 | United States | Details |
| Levine Cancer Institute | RECRUITING | Charlotte | North Carolina | 28204 | United States | Details |
| Novant Health Cancer Institute - Charlotte | RECRUITING | Charlotte | North Carolina | 28204 | United States | Details |
| Duke University Medical Center | RECRUITING | Durham | North Carolina | 27705 | United States | Details |
| The Ohio State University Wexner Medical Center | RECRUITING | Columbus | Ohio | 43210 | United States | Details |
| Tennessee Oncology | RECRUITING | Chattanooga | Tennessee | 37404 | United States | Details |
| SCRI - Tennessee Oncology | RECRUITING | Nashville | Tennessee | 37203 | United States | Details |
| Houston Methodist Hospital Cancer Center | RECRUITING | Houston | Texas | 77030 | United States | Details |
| University of Texas MD Anderson Cancer Center | RECRUITING | Houston | Texas | 77030 | United States | Details |
| Baylor Scott & White Health | RECRUITING | Round Rock | Texas | 78665 | United States | Details |
| University Of Virginia | RECRUITING | Charlottesville | Virginia | 22903 | United States | Details |
| Virginia Commonwealth University (VCU) Massey Cancer Center | RECRUITING | Richmond | Virginia | 843042 | United States | Details |
| Swedish Cancer Institute | RECRUITING | Seattle | Washington | 98104 | United States | Details |
| MultiCare Health System Institute for Research and Innovation | RECRUITING | Spokane | Washington | 99218 | United States | Details |
| UW Cancer Center at ProHealth Care | RECRUITING | Waukesha | Wisconsin | 53188 | United States | Details |
| Border Medical Oncology | RECRUITING | Albury | New South Wales | 2640 | Australia | Details |
| Concord Repatriation General Hospital | RECRUITING | Concord | New South Wales | 2139 | Australia | Details |
| Royal Adelaide Hospital | RECRUITING | Adelaide | South Australia | 5000 | Australia | Details |
| Flinders Medical Centre | RECRUITING | Adelaide | South Australia | 5042 | Australia | Details |
| Royal Hobart Hospital | RECRUITING | Hobart | Tasmania | 7000 | Australia | Details |
| St. Vincent's Hospital | RECRUITING | Fitzroy | Victoria | 3065 | Australia | Details |
| Peninsula Private Hospital | RECRUITING | Frankston | Victoria | 3199 | Australia | Details |
| The Alfred Hospital | RECRUITING | Melbourne | Victoria | 3004 | Australia | Details |
| Fiona Stanley Hospital | RECRUITING | Murdoch | Western Australia | 6150 | Australia | Details |
| Sir Charles Gairdner Hospital | RECRUITING | Nedlands | Western Australia | 6009 | Australia | Details |
| Universitair Ziekenhuis Gent | RECRUITING | Gent | 900 | Belgium | Details | |
| Hôpital de Jolimont | RECRUITING | Haine-Saint-Paul | 7100 | Belgium | Details | |
| CHU UCL Namur | RECRUITING | Yvoir | 5530 | Belgium | Details | |
| Tom Baker Cancer Centre | RECRUITING | Calgary | Alberta | T2N 4N2 | Canada | Details |
| Foothills Medical Centre | RECRUITING | Calgary | Alberta | T2N4N2 | Canada | Details |
| Cross Cancer Institute | RECRUITING | Edmonton | Alberta | T6G 1Z2 | Canada | Details |
| BC Cancer Vancouver | RECRUITING | Vancouver | British Columbia | V5Z4E6 | Canada | Details |
| CancerCare Manitoba | RECRUITING | Winnipeg | Manitoba | R3E 0V9 | Canada | Details |
| Sunnybrook Health Sciences Centre | RECRUITING | Toronto | Ontario | M4N3M5 | Canada | Details |
| CIUSSS du Centre Ouest de l'lle de Montreal | RECRUITING | Montreal | Quebec | H3T 1E2 | Canada | Details |
| The First Affiliated Hospital of Anhui Medical University | RECRUITING | Hefei | Anhui | 230022 | China | Details |
| Peking University First Hospital | RECRUITING | Beijing | Beijing | 100034 | China | Details |
| Fujian Cancer Hospital | RECRUITING | Fuzhou | Fujian | 350015 | China | Details |
| Affiliated Cancer Hospital and Institute of Guangzhou Medical University | RECRUITING | Guangzhou | Guangdong | 510000 | China | Details |
| Zhongshan City People's Hospital | RECRUITING | Zhongshan | Guangdong | 528403 | China | Details |
| Guangxi Medical University Cancer Hospital | RECRUITING | Nanning | Guangxi | 530021 | China | Details |
| Henan Provincial People's Hospital | RECRUITING | Zhengzhou | Henan | 450003 | China | Details |
| Tongji Hospital Affiliated to Tongji Medicine University | RECRUITING | Wuhan City | Hubei | 430030 | China | Details |
| Union Hospital,Tongji Medical College, Huazhong University of Science and Technology | RECRUITING | Wuhan | Hubei | 430022 | China | Details |
| Yichang Central People's Hospital | RECRUITING | Yichang | Hubei | 443003 | China | Details |
| The Second Xiangya Hospital of Central South University | RECRUITING | Changsha | Hunan | 410011 | China | Details |
| The First Affiliated Hospital Of University Of South China | RECRUITING | Hengshan | Hunan | 421001 | China | Details |
| The Affiliated Hospital of Inner Mongolia Medical University | RECRUITING | Hohhot | Inner Mongolia | 10050 | China | Details |
| Nantong Tumor Hospital | RECRUITING | Nantong | Jiangsu | 226361 | China | Details |
| Wuxi People's Hospital | RECRUITING | Wuxi | Jiangsu | 214023 | China | Details |
| Jiangxi Cancer Hospital | RECRUITING | Nanchang | Jiangxi | 330029 | China | Details |
| Shengjing Hospital of China Medical University | RECRUITING | Shenyang | Liaoning | 110022 | China | Details |
| Jiangsu Province Hospital | RECRUITING | Nanjing | Nanjing | 210029 | China | Details |
| The Affiliated Hospital of Qingdao University | RECRUITING | Qingdao City | Shandong | 266555 | China | Details |
| Shanghai Tongren Hospital | RECRUITING | Changning District | Shanghai | 200050 | China | Details |
| Ruijin Hospital of Shanghai Jiaotong University School of Medicine | RECRUITING | Shanghai | Shanghai | 200025 | China | Details |
| Tianjin Medical University Cancer Institute and Hospital | RECRUITING | Tianjin | Tianjin | 300060 | China | Details |
| The First People's Hospital of Yunnan Province | RECRUITING | Kunming | Yunnan | 650034 | China | Details |
| First Affiliated Hosp of College of Med, Zhejiang University | RECRUITING | Hangzhou | Zhejiang | 310003 | China | Details |
| Chongqing University Cancer Hospital | RECRUITING | Chongqing | 400030 | China | Details | |
| Fakultni nemocnice Brno | RECRUITING | Brno | 62500 | Czechia | Details | |
| Fakultni nemocnice Hradec Kralove | RECRUITING | Hradec Kralove | 500 05 | Czechia | Details | |
| Fakultni nemocnice Kralovske Vinohrady | RECRUITING | Praha 10 | 100 34 | Czechia | Details | |
| Vseobecna fakultni nemocnice v Praze | RECRUITING | Praha 2 | 12808 | Czechia | Details | |
| Rigshospitalet | RECRUITING | Copenhagen | 2100 | Denmark | Details | |
| Institut de Cancérologie de Strasbourg Europe - ICANS | RECRUITING | Strasbourg Cedex | Bas Rhin | 67033 | France | Details |
| Groupe Hospitalier Pitie-Salpetriere | RECRUITING | Paris | Cedex 13 | 75651 | France | Details |
| CHU de Nantes - Hôtel-Dieu | RECRUITING | Nantes | Cedex 1 | 44093 | France | Details |
| CHU Rennes - Hopital Pontchaillou | RECRUITING | Rennes | Cedex 9 | 35033 | France | Details |
| Institut Universitaire du Cancer de Toulouse- IUCT-O | RECRUITING | Toulouse | Cedex 9 | 31100 | France | Details |
| Centre Hospitalier Lyon Sud | RECRUITING | Pierre-Bénite | Cedex | 69495 | France | Details |
| CHU de Limoges - Hôpital Dupuytren | RECRUITING | Limoges | France Cédex | 87042 | France | Details |
| Hopital Saint Eloi | RECRUITING | Montpellier Cedex 5 | Herault | 34295 | France | Details |
| Hôpital Saint-Louis | RECRUITING | Paris cedex 10 | Paris | 75475 | France | Details |
| Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen | RECRUITING | Rouen | Seine-Maritime | 76038 | France | Details |
| CHU Tours - Hôpital Bretonneau | RECRUITING | Tours | Tours Cedex 9 | 37044 | France | Details |
| CHU Poitiers - Hôpital la Milétrie | RECRUITING | Politiers | Vienne | 86021 | France | Details |
| Centre Hospitalier du Mans | RECRUITING | Le Mans | 72000 | France | Details | |
| CHU de Nancy - Hôpital de Brabois Adultes | RECRUITING | Vandœuvre-lès-Nancy | 54500 | France | Details | |
| Muenchen Klinikum Schwabing | RECRUITING | Muenchen | Bayern | 80804 | Germany | Details |
| Universitaetsmedizin Rostock | RECRUITING | Rostock | Mecklenburg Vorpommern | 18057 | Germany | Details |
| Universitaetsklinikum Koeln | RECRUITING | Koeln | Nordrhein Westfalen | 50937 | Germany | Details |
| Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz | RECRUITING | Mainz | Rheinland Pfalz | 55131 | Germany | Details |
| Klinikum Chemnitz gGmbH | RECRUITING | Chemnitz | Sachsen | 9113 | Germany | Details |
| Universitaetsklinikum Leipzig AoeR | RECRUITING | Leipzig | Sachsen | 4103 | Germany | Details |
| Charité Universitaetsmedizin Berlin - Campus Benjamin Franklin | RECRUITING | Berlin | 12203 | Germany | Details | |
| Orszagos Onkologiai Intezet | RECRUITING | Budapest | 1122 | Hungary | Details | |
| Debreceni Egyetem | RECRUITING | Debrecen | 4032 | Hungary | Details | |
| Somogy Varmegyei Kaposi Mor Oktato Korhaz | RECRUITING | Kaposvar | 7400 | Hungary | Details | |
| Mater Misericordiae University Hospital | RECRUITING | Dublin | D07 R2WY | Ireland | Details | |
| University Hospital Waterford | RECRUITING | Waterford | X91 ER8E | Ireland | Details | |
| Bnai Zion Medical Center | RECRUITING | Haifa | 3339419 | Israel | Details | |
| Health Corporation of Galilee Medical Center | RECRUITING | Naharia | 2210010 | Israel | Details | |
| Rabin Medical Center-Beilinson Campus | RECRUITING | Petah-Tikva | 4941492 | Israel | Details | |
| Kaplan Medical Center | RECRUITING | Reẖovot | 76100 | Israel | Details | |
| Tel Aviv Sourasky Medical Center | RECRUITING | Tel Aviv | 6423906 | Israel | Details | |
| Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS | RECRUITING | Bologna | 40138 | Italy | Details | |
| Azienda Ospedaliera di Catanzaro "Pugliese-Ciaccio" | RECRUITING | Catanzaro | 88100 | Italy | Details | |
| Azienda Ospedaliera Universitaria Arcispedale Sant'Anna | RECRUITING | Cona | 44124 | Italy | Details | |
| Azienda Ospedaliera Santa Croce e Carle | RECRUITING | Cuneo | 12100 | Italy | Details | |
| Azienda Ospedaliera Universitaria Careggi | RECRUITING | Firenze | 50134 | Italy | Details | |
| IRCCS Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" - IRST | RECRUITING | Meldola | 47014 | Italy | Details | |
| Ospedale San Raffaele | RECRUITING | Milano | 20132 | Italy | Details | |
| Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda) | RECRUITING | Milano | 20162 | Italy | Details | |
| A.O.U. Policlinico di Modena | RECRUITING | Modena | 41124 | Italy | Details | |
| Ospedale Maggiore di Novara | RECRUITING | Novara | 28100 | Italy | Details | |
| Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza | RECRUITING | Roma | 00161 | Italy | Details | |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | RECRUITING | Roma | 00168 | Italy | Details | |
| Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino | RECRUITING | Torino | 10126 | Italy | Details | |
| Nagoya City University Hospital | RECRUITING | Nagoya-shi | Aichi-Ken | 467-8602 | Japan | Details |
| NHO Nagoya Medical Center | RECRUITING | Nagoya | Aichi | 460-0001 | Japan | Details |
| Hokkaido University Hospital | RECRUITING | Sapporo | Hokkaido | 060-8648 | Japan | Details |
| Kanagawa cancer center | RECRUITING | Yokohama | Kanagawa | 241-8515 | Japan | Details |
| Kochi Medical School Hospital | RECRUITING | Nankoku | Kochi | 783-8505 | Japan | Details |
| University Hospital, Kyoto Prefectural University of Medicine | RECRUITING | Kyoto-shi | Kyoto | 602-8566 | Japan | Details |
| Tohoku University Hospital | RECRUITING | Sendai-shi | Miyagi | 980-8574 | Japan | Details |
| Kindai University Hospital | RECRUITING | Osaka Sayama-shi | Osaka | 589 8511 | Japan | Details |
| Saitama Medical Center | RECRUITING | Kawagoe-shi | Saitama-Ken | 350-8550 | Japan | Details |
| National Cancer Center Hospital | RECRUITING | Chuo-ku | Tokyo | 104-0045 | Japan | Details |
| Cancer Institute Hospital of JFCR | RECRUITING | Koto | Tokyo | 135-8550 | Japan | Details |
| Ome Municipal General Hospital | RECRUITING | Ome | Tokyo | 198-0042 | Japan | Details |
| NTT Medical Center Tokyo | RECRUITING | Shinagawa-Ku | Tokyo | 141-8625 | Japan | Details |
| University of Fukui Hospital | RECRUITING | Fukui | 9101193 | Japan | Details | |
| Kumamoto University Hospital | RECRUITING | Kumamoto | 860-8556 | Japan | Details | |
| Okayama University Hospital | RECRUITING | Okayama | 700-8558 | Japan | Details | |
| Severance Hospital, Yonsei University Health System | RECRUITING | Seoul | Seoul-teukbyeolsi [Seoul] | 03722 | Korea, Republic of | Details |
| The Catholic University of Korea-Seoul St. Mary's Hospital | RECRUITING | Seocho-Gu | Seoul | 06591 | Korea, Republic of | Details |
| Seoul National University Hospital | RECRUITING | Seoul | 03080 | Korea, Republic of | Details | |
| Samsung Medical Center | RECRUITING | Seoul | 06351 | Korea, Republic of | Details | |
| Szpitale Pomorskie spółka z ograniczoną odpowiedzialnością | RECRUITING | Gdynia | Pomorskie | 81-519 | Poland | Details |
| Pratia Onkologia Katowice | RECRUITING | Katowice | 40519 | Poland | Details | |
| Pratia MCM Krakow | RECRUITING | Krakow | 30-510 | Poland | Details | |
| Instytut Hematologii i Transfuzjologii | RECRUITING | Warszawa | 02-776 | Poland | Details | |
| Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi | RECRUITING | Łódź | 93510 | Poland | Details | |
| National Cancer Centre Singapore | RECRUITING | Singapore | 169610 | Singapore | Details | |
| Singapore General Hospital | RECRUITING | Singapore | 169856 | Singapore | Details | |
| Hospital Universitario Central de Asturias | RECRUITING | Oviedo | Asturias | 33011 | Spain | Details |
| Complejo Hospitalario de Toledo | RECRUITING | Toledo | Castilla La Mancha | 45004 | Spain | Details |
| Hospital Universitario Puerta de Hierro Majadahonda | RECRUITING | Majadahonda | Madrid | 28222 | Spain | Details |
| Hospital Costa Del Sol | RECRUITING | Marbella | Malaga | 29603 | Spain | Details |
| Hospital Universitario de La Princesa | RECRUITING | Salamanca | Mandrid | 28006 | Spain | Details |
| Hospital Universitario Quironsalud Madrid | RECRUITING | Madrid | Pozuelo De Alarcón | 28223 | Spain | Details |
| Hospital Universitari Vall d'Hebron | RECRUITING | Barcelona | 8035 | Spain | Details | |
| Hospital Universitario Infanta Leonor | RECRUITING | Madrid | 28031 | Spain | Details | |
| Hospital Universitario Fundación Jiménez Díaz | RECRUITING | Madrid | 28040 | Spain | Details | |
| Hospital Universitario Virgen Macarena | RECRUITING | Sevilla | 41009 | Spain | Details | |
| Hospital Universitario Virgen del Rocío | RECRUITING | Sevilla | 41013 | Spain | Details | |
| Hospital Universitari i Politecnic La Fe | RECRUITING | Valencia | 46026 | Spain | Details | |
| Skane University Hospital | RECRUITING | Lund | 22185 | Sweden | Details | |
| Karolinska Universitetssjukhuset, Huddinge | RECRUITING | Stockholm | 141 86 | Sweden | Details | |
| Akademiska Sjukhuset | RECRUITING | Uppsala | 75185 | Sweden | Details | |
| Istituto Oncologico della Svizzera Italiana (IOSI)- Ente Ospedaliero Cantonale (EOC) | RECRUITING | Bellinzona | Ticino | 6500 | Switzerland | Details |
| Luzerner Kantonsspital - Luzern | RECRUITING | Luzern | 6000 | Switzerland | Details | |
| Chang Gung Memorial Hospital - Linkou | RECRUITING | Guei Shan Township | Taoyuan City | 333 | Taiwan | Details |
| National Taiwan University Hospital | RECRUITING | Taipei | 10002 | Taiwan | Details | |
| Derriford Hospital | RECRUITING | Plymouth | Devon | PL6 8DH | United Kingdom | Details |
| Leicester Royal Infirmary | RECRUITING | Leicester | England | LE15WW | United Kingdom | Details |
| Birmingham Heartlands Hospital | RECRUITING | Birmingham | West Midlands | B9 5SS | United Kingdom | Details |
| St James's University Hospital | RECRUITING | Leeds | West Yorkshire | LS97TF | United Kingdom | Details |
| Churchill Hospital | RECRUITING | Oxford | OX3 7LJ | United Kingdom | Details | |
| Royal Marsden Hospital | RECRUITING | Surrey | SM2 5PT | United Kingdom | Details |