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| NCT ID | NCT05048797 |
| Title | A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | Yes |
| Sponsors | AstraZeneca |
| Indications | |
| Therapies | |
| Age Groups: | senior |
| Covered Countries | USA | NLD | ITA | FRA | ESP | DEU | CAN | BEL | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Research Site | RECRUITING | Anchorage | Alaska | 99508 | United States | Details |
| Research Site | RECRUITING | Los Alamitos | California | 90720 | United States | Details |
| Research Site | RECRUITING | Los Angeles | California | 90048 | United States | Details |
| Research Site | RECRUITING | Orange | California | 92868 | United States | Details |
| Research Site | RECRUITING | San Francisco | California | 94143 | United States | Details |
| Research Site | RECRUITING | Santa Monica | California | 90404 | United States | Details |
| Research Site | RECRUITING | Santa Rosa | California | 95403 | United States | Details |
| Research Site | RECRUITING | Silver Spring | Maryland | 20910 | United States | Details |
| Research Site | WITHDRAWN | Boston | Massachusetts | 02118 | United States | Details |
| Research Site | RECRUITING | Boston | Massachusetts | 02215 | United States | Details |
| Research Site | RECRUITING | Ann Arbor | Michigan | 48109 | United States | Details |
| Research Site | RECRUITING | Basking Ridge | New Jersey | 07920 | United States | Details |
| Research Site | RECRUITING | East Brunswick | New Jersey | 08816 | United States | Details |
| Research Site | RECRUITING | Middletown | New Jersey | 07748 | United States | Details |
| Research Site | RECRUITING | Montvale | New Jersey | 07645 | United States | Details |
| Research Site | RECRUITING | New Brunswick | New Jersey | 08901 | United States | Details |
| Research Site | RECRUITING | Commack | New York | 11725 | United States | Details |
| Research Site | RECRUITING | Harrison | New York | 10604 | United States | Details |
| Research Site | RECRUITING | New York | New York | 10065 | United States | Details |
| Research Site | RECRUITING | Uniondale | New York | 11553 | United States | Details |
| Research Site | RECRUITING | Canton | Ohio | 44710 | United States | Details |
| Research Site | WITHDRAWN | Columbus | Ohio | 43201 | United States | Details |
| Research Site | RECRUITING | Pittsburgh | Pennsylvania | 15232 | United States | Details |
| Research Site | RECRUITING | Dallas | Texas | 75246 | United States | Details |
| Research Site | RECRUITING | Kennewick | Washington | 99336 | United States | Details |
| Research Site | WITHDRAWN | La Crosse | Wisconsin | 54601 | United States | Details |
| Research Site | WITHDRAWN | Milwaukee | Wisconsin | 53226 | United States | Details |
| Research Site | WITHDRAWN | Graz | 8036 | Austria | Details | |
| Research Site | SUSPENDED | Innsbruck | 6020 | Austria | Details | |
| Research Site | RECRUITING | Linz | 4020 | Austria | Details | |
| Research Site | WITHDRAWN | Rankweil | 6830 | Austria | Details | |
| Research Site | RECRUITING | Wien | 1210 | Austria | Details | |
| Research Site | RECRUITING | Gent | 9000 | Belgium | Details | |
| Research Site | RECRUITING | Hasselt | 3500 | Belgium | Details | |
| Research Site | RECRUITING | Leuven | 3000 | Belgium | Details | |
| Research Site | RECRUITING | Barretos | 14784-400 | Brazil | Details | |
| Research Site | RECRUITING | Blumenau | 89010-340 | Brazil | Details | |
| Research Site | RECRUITING | Brasília | 70200-730 | Brazil | Details | |
| Research Site | RECRUITING | Florianópolis | 88034-000 | Brazil | Details | |
| Research Site | RECRUITING | Natal | 59075-740 | Brazil | Details | |
| Research Site | RECRUITING | Salvador | 40170-110 | Brazil | Details | |
| Research Site | RECRUITING | Sao Paulo | 01327-001 | Brazil | Details | |
| Research Site | RECRUITING | São Paulo | 01321-001 | Brazil | Details | |
| Research Site | RECRUITING | Uberlândia | 38408-150 | Brazil | Details | |
| Research Site | RECRUITING | Vancouver | British Columbia | V5Z 4E6 | Canada | Details |
| Research Site | RECRUITING | Brampton | Ontario | L6R 3J7 | Canada | Details |
| Research Site | RECRUITING | Toronto | Ontario | M5G 1Z5 | Canada | Details |
| Research Site | RECRUITING | Montreal | Quebec | H4A 3J1 | Canada | Details |
| Research Site | RECRUITING | Beijing | 100142 | China | Details | |
| Research Site | RECRUITING | Beijing | 100730 | China | Details | |
| Research Site | RECRUITING | Changchun | 130021 | China | Details | |
| Research Site | RECRUITING | Changsha | 410008 | China | Details | |
| Research Site | RECRUITING | Changsha | 410013 | China | Details | |
| Research Site | RECRUITING | Chengdu | 610041 | China | Details | |
| Research Site | RECRUITING | Fuzhou | 350014 | China | Details | |
| Research Site | RECRUITING | Guangzhou | 510080 | China | Details | |
| Research Site | RECRUITING | Hangzhou | 310020 | China | Details | |
| Research Site | WITHDRAWN | Harbin | 150049 | China | Details | |
| Research Site | RECRUITING | Jinan | 250117 | China | Details | |
| Research Site | RECRUITING | Kunming | 650101 | China | Details | |
| Research Site | RECRUITING | Kunming | 650118 | China | Details | |
| Research Site | RECRUITING | Linhai | 317000 | China | Details | |
| Research Site | SUSPENDED | Nanchang | 330006 | China | Details | |
| Research Site | RECRUITING | Nanjing | 210029 | China | Details | |
| Research Site | WITHDRAWN | Shanghai | 200030 | China | Details | |
| Research Site | RECRUITING | Shanghai | 200032 | China | Details | |
| Research Site | RECRUITING | Shenyang | 110001 | China | Details | |
| Research Site | RECRUITING | Shenyang | 110016 | China | Details | |
| Research Site | RECRUITING | ShenZhen | 518020 | China | Details | |
| Research Site | RECRUITING | Wenzhou | CN-325000 | China | Details | |
| Research Site | RECRUITING | Wuhan | 430022 | China | Details | |
| Research Site | RECRUITING | Xi'an | 710061 | China | Details | |
| Research Site | RECRUITING | Xiamen | 361003 | China | Details | |
| Research Site | RECRUITING | Yangzhou | 225001 | China | Details | |
| Research Site | WITHDRAWN | Zhengzhou City | 450008 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Vejle | 7100 | Denmark | Details | |
| Research Site | RECRUITING | Bordeaux | 33000 | France | Details | |
| Research Site | RECRUITING | Dijon | 21079 | France | Details | |
| Research Site | RECRUITING | Le Mans Cedex | 72037 | France | Details | |
| Research Site | RECRUITING | Lyon | 69373 | France | Details | |
| Research Site | RECRUITING | Marseille cedex | 13915 | France | Details | |
| Research Site | RECRUITING | Nantes | 44093 | France | Details | |
| Research Site | WITHDRAWN | Rennes Cedex 9 | 35033 | France | Details | |
| Research Site | RECRUITING | Toulouse Cedex 9 | 31059 | France | Details | |
| Research Site | RECRUITING | Villejuif Cedex | 94805 | France | Details | |
| Research Site | WITHDRAWN | Berlin-Zehlendorf | 14165 | Germany | Details | |
| Research Site | RECRUITING | Dresden | 01307 | Germany | Details | |
| Research Site | WITHDRAWN | Erfurt | 99089 | Germany | Details | |
| Research Site | WITHDRAWN | Heidelberg | 69126 | Germany | Details | |
| Research Site | WITHDRAWN | Immenhausen | 34376 | Germany | Details | |
| Research Site | RECRUITING | Köln | 50937 | Germany | Details | |
| Research Site | RECRUITING | Mainz | 55131 | Germany | Details | |
| Research Site | WITHDRAWN | Mannheim | 68167 | Germany | Details | |
| Research Site | RECRUITING | München | 81377 | Germany | Details | |
| Research Site | RECRUITING | Oldenburg | 26121 | Germany | Details | |
| Research Site | WITHDRAWN | Ravensburg | 88212 | Germany | Details | |
| Research Site | WITHDRAWN | Würzburg | 97080 | Germany | Details | |
| Research Site | RECRUITING | Hong Kong | Hong Kong | Details | ||
| Research Site | RECRUITING | Jordan | Hong Kong | Details | ||
| Research Site | NOT_YET_RECRUITING | Shatin | 00000 | Hong Kong | Details | |
| Research Site | RECRUITING | Bangalore | 560027 | India | Details | |
| Research Site | RECRUITING | Delhi | 110085 | India | Details | |
| Research Site | RECRUITING | Hyderabad | 500032 | India | Details | |
| Research Site | RECRUITING | Mumbai | 400012 | India | Details | |
| Research Site | RECRUITING | Nashik | 422002 | India | Details | |
| Research Site | RECRUITING | Milan | 20141 | Italy | Details | |
| Research Site | RECRUITING | Monza | 20090 | Italy | Details | |
| Research Site | RECRUITING | Orbassano | 10043 | Italy | Details | |
| Research Site | RECRUITING | Parma | 43100 | Italy | Details | |
| Research Site | RECRUITING | Roma | 00168 | Italy | Details | |
| Research Site | RECRUITING | Verona | 37126 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Chuo-ku | 104-0045 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Fukuoka-shi | 812-8582 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Kashiwa | 277-8577 | Japan | Details | |
| Research Site | RECRUITING | Matsuyama-shi | 791-0280 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Niigata-shi | 951-8566 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Okayama-shi | 700-8558 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Osaka-shi | 541-8567 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Osakasayama-shi | 589-8511 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Sapporo-shi | 060-8638 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Sendai-shi | 980-0873 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Sunto-gun | 411-8777 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Yokohama-shi | 241-8515 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Yonago-shi | 683-8504 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Cheongju-si | 28644 | Korea, Republic of | Details | |
| Research Site | RECRUITING | Goyang-si | 10408 | Korea, Republic of | Details | |
| Research Site | RECRUITING | Gyeonggi-do | 13620 | Korea, Republic of | Details | |
| Research Site | RECRUITING | Seoul | 03080 | Korea, Republic of | Details | |
| Research Site | RECRUITING | Seoul | 05505 | Korea, Republic of | Details | |
| Research Site | RECRUITING | Seoul | 06351 | Korea, Republic of | Details | |
| Research Site | RECRUITING | Cdmx | 03810 | Mexico | Details | |
| Research Site | WITHDRAWN | Culiacán | 80230 | Mexico | Details | |
| Research Site | WITHDRAWN | Guadalajara Jalisco | 44280 | Mexico | Details | |
| Research Site | WITHDRAWN | Merida | 97000 | Mexico | Details | |
| Research Site | RECRUITING | Mexico City | '14080 | Mexico | Details | |
| Research Site | RECRUITING | Oaxaca | 68020 | Mexico | Details | |
| Research Site | WITHDRAWN | San Luis Potosí | 78200 | Mexico | Details | |
| Research Site | RECRUITING | Amsterdam | 1081 HV | Netherlands | Details | |
| Research Site | RECRUITING | Groningen | 9700 RB | Netherlands | Details | |
| Research Site | WITHDRAWN | Leiden | 2333 ZA | Netherlands | Details | |
| Research Site | RECRUITING | Nijmegen | 6525 GA | Netherlands | Details | |
| Research Site | RECRUITING | Bystra | 43-360 | Poland | Details | |
| Research Site | RECRUITING | Gdańsk | 80-214 | Poland | Details | |
| Research Site | RECRUITING | Olsztyn | 10-357 | Poland | Details | |
| Research Site | RECRUITING | Przemysl | 37-700 | Poland | Details | |
| Research Site | RECRUITING | Warszawa | 02-781 | Poland | Details | |
| Research Site | RECRUITING | L'Hospitalet de Llobregat | 08908 | Spain | Details | |
| Research Site | RECRUITING | Madrid | 28041 | Spain | Details | |
| Research Site | RECRUITING | Malaga | 29730 | Spain | Details | |
| Research Site | RECRUITING | Valencia | 46026 | Spain | Details | |
| Research Site | RECRUITING | Kaohsiung | 833 | Taiwan | Details | |
| Research Site | RECRUITING | Taichung | 40201 | Taiwan | Details | |
| Research Site | RECRUITING | Taichung | 40705 | Taiwan | Details | |
| Research Site | RECRUITING | Tainan | 70403 | Taiwan | Details | |
| Research Site | RECRUITING | Taipei | 10048 | Taiwan | Details | |
| Research Site | RECRUITING | Taipei | 235 | Taiwan | Details | |
| Research Site | RECRUITING | Taipei | TAIWAN | Taiwan | Details | |
| Research Site | RECRUITING | Taoyuan | 333 | Taiwan | Details | |
| Research Site | RECRUITING | Edirne | 22030 | Turkey | Details | |
| Research Site | RECRUITING | Izmir | 35040 | Turkey | Details | |
| Research Site | RECRUITING | Kadıkoy/Istanbul | 34722 | Turkey | Details | |
| Research Site | RECRUITING | Çankaya | 06680 | Turkey | Details |