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| NCT ID | NCT05113251 |
| Title | Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | AstraZeneca |
| Indications | |
| Therapies | |
| Age Groups: | senior | adult |
| Covered Countries | USA | ITA | ESP | DEU | CAN | AUT |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Research Site | ACTIVE_NOT_RECRUITING | Springdale | Arkansas | 72762 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Beverly Hills | California | 90211 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Glendale | California | 91204 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Los Alamitos | California | 90720 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Orange | California | 92868 | United States | Details |
| Research Site | WITHDRAWN | Denver | Colorado | 80218 | United States | Details |
| Research Site | RECRUITING | Grand Junction | Colorado | 81501 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | New Haven | Connecticut | 06510 | United States | Details |
| Research Site | WITHDRAWN | Fort Myers | Florida | 33901 | United States | Details |
| Research Site | WITHDRAWN | Miami | Florida | 33136 | United States | Details |
| Research Site | WITHDRAWN | Saint Petersburg | Florida | 33705 | United States | Details |
| Research Site | WITHDRAWN | Tallahassee | Florida | 32308 | United States | Details |
| Research Site | WITHDRAWN | West Palm Beach | Florida | 33401 | United States | Details |
| Research Site | WITHDRAWN | Coeur d'Alene | Idaho | 83814 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Fort Wayne | Indiana | 46804 | United States | Details |
| Research Site | COMPLETED | Lexington | Kentucky | 40503 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Louisville | Kentucky | 40202 | United States | Details |
| Research Site | TERMINATED | Shreveport | Louisiana | 71101 | United States | Details |
| Research Site | RECRUITING | Scarborough | Maine | 04074 | United States | Details |
| Research Site | RECRUITING | Baltimore | Maryland | 21201 | United States | Details |
| Research Site | WITHDRAWN | Grand Rapids | Michigan | 49503 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Minneapolis | Minnesota | 55407 | United States | Details |
| Research Site | WITHDRAWN | Billings | Montana | 59102 | United States | Details |
| Research Site | WITHDRAWN | Omaha | Nebraska | 68198 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Las Vegas | Nevada | 89102 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | East Brunswick | New Jersey | 08816 | United States | Details |
| Research Site | WITHDRAWN | Hackensack | New Jersey | 07601 | United States | Details |
| Research Site | WITHDRAWN | Little Silver | New Jersey | 07739 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Summit | New Jersey | 07901 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Commack | New York | 11725 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Durham | North Carolina | 27710 | United States | Details |
| Research Site | WITHDRAWN | Pittsburgh | Pennsylvania | 15213 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Greenville | South Carolina | 29607 | United States | Details |
| Research Site | TERMINATED | Germantown | Tennessee | 38138 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Nashville | Tennessee | 37203 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Fort Worth | Texas | 76104 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Ogden | Utah | 84405 | United States | Details |
| Research Site | WITHDRAWN | Salt Lake City | Utah | 84106 | United States | Details |
| Research Site | WITHDRAWN | Burlington | Vermont | 05401 | United States | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Tacoma | Washington | 98405 | United States | Details |
| Research Site | WITHDRAWN | Innsbruck | 6020 | Austria | Details | |
| Research Site | WITHDRAWN | Salzburg | 5020 | Austria | Details | |
| Research Site | WITHDRAWN | Wien | 1130 | Austria | Details | |
| Research Site | WITHDRAWN | Wien | 1190 | Austria | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Goiânia | 74000-000 | Brazil | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Ijuí | 98700-000 | Brazil | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Natal | 59075-740 | Brazil | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Porto Alegre | 90610-000 | Brazil | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Porto Alegre | 91350-200 | Brazil | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | São Paulo | 01221-020 | Brazil | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | São Paulo | 01229-010 | Brazil | Details | |
| Research Site | WITHDRAWN | Vitoria | 29043-260 | Brazil | Details | |
| Research Site | COMPLETED | Panagyurishte | 4500 | Bulgaria | Details | |
| Research Site | WITHDRAWN | Pleven | 5804 | Bulgaria | Details | |
| Research Site | WITHDRAWN | Plovdiv | 4000 | Bulgaria | Details | |
| Research Site | WITHDRAWN | Sofia | 1303 | Bulgaria | Details | |
| Research Site | COMPLETED | Sofia | 1330 | Bulgaria | Details | |
| Research Site | WITHDRAWN | Sofia | 1407 | Bulgaria | Details | |
| Research Site | WITHDRAWN | Sofia | Bulgaria | Details | ||
| Research Site | ACTIVE_NOT_RECRUITING | Edmonton | Alberta | T6G 1Z2 | Canada | Details |
| Research Site | WITHDRAWN | Victoria | British Columbia | V8R 6V5 | Canada | Details |
| Research Site | WITHDRAWN | Sault Ste. Marie | Ontario | P6A 0A8 | Canada | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Toronto | Ontario | M5G 1X5 | Canada | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Montreal | Quebec | H4A-3J1 | Canada | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Quebec City | Quebec | G1S 4L8 | Canada | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Sherbrooke | Quebec | J1H 5N4 | Canada | Details |
| Research Site | ACTIVE_NOT_RECRUITING | Montreal | H3T 1E2 | Canada | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Beijing | 100039 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Changsha | 410008 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Changsha | 410013 | China | Details | |
| Research Site | RECRUITING | Chengdu | 610041 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Chongqing | 400030 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Guangzhou | 510060 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Guangzhou | 510080 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Guangzhou | 510700 | China | Details | |
| Research Site | WITHDRAWN | Hangzhou | 310022 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Kunming | 650118 | China | Details | |
| Research Site | TERMINATED | Nanjing | 210029 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Nanning | 530021 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Qingdao | 266100 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Shanghai | 200032 | China | Details | |
| Research Site | TERMINATED | Shanghai | 200433 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Shenyang | 110001 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Tianjin | 300060 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Wuhan | 430060 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Wuhan | 430079 | China | Details | |
| Research Site | WITHDRAWN | Xi'an | 710032 | China | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Zhengzhou | 450008 | China | Details | |
| Research Site | WITHDRAWN | Aschaffenburg | 63739 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Augsburg | 86156 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Berlin | 10117 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Erlangen | 91054 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Hamburg | 20357 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Heidelberg | 69120 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Kiel | 24105 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Leipzig | 4103 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Muenster | 48149 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Mönchengladbach | 41061 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | München | 81377 | Germany | Details | |
| Research Site | WITHDRAWN | Offenbach am Main | 63069 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Paderborn | 33098 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Tübingen | 72076 | Germany | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Gurgaon | 122001 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Howrah | 711103 | India | Details | |
| Research Site | WITHDRAWN | Ludhiana | 141002 | India | Details | |
| Research Site | WITHDRAWN | Manipal | 576104 | India | Details | |
| Research Site | WITHDRAWN | Mumbai | 400012 | India | Details | |
| Research Site | WITHDRAWN | Mumbai | 400092 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Nagpur | 440001 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Nashik | 422002 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | New Delhi | 110 085 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | New Delhi | 110029 | India | Details | |
| Research Site | TERMINATED | Raipur | 492001 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Rishikesh | 249203 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Surat | 395002 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Thiruvananthapuram | 695011 | India | Details | |
| Research Site | WITHDRAWN | Vadodara | 390012 | India | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Bologna | 40138 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Candiolo | 10060 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Livorno | 57100 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Milano | 20132 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Naples | 80131 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Napoli | 80131 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Negrar | 37024 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Padova | 35128 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Rome | 168 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Rozzano | 20089 | Italy | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Chuo-ku | 104-8560 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Chuo-ku | 862-8655 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Hidaka-shi | 350-1298 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Hiroshima-shi | 734-8551 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Kawasaki-shi | 216-8511 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Koto-ku | 135-8550 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Nagoya-shi | 466-8560 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Nagoya-shi | 467-0001 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Ota-shi | 373-8550 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Shinjuku-ku | 162-8655 | Japan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Goyang-si | 10408 | Korea, Republic of | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Seoul | 03080 | Korea, Republic of | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Seoul | 03722 | Korea, Republic of | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Seoul | 05505 | Korea, Republic of | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Seoul | 06273 | Korea, Republic of | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Seoul | 06351 | Korea, Republic of | Details | |
| Research Site | WITHDRAWN | Arequipa | AREQUIPA01 | Peru | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Lima | 15033 | Peru | Details | |
| Research Site | WITHDRAWN | Lima | L41 | Peru | Details | |
| Research Site | WITHDRAWN | Lima | LIMA 27 | Peru | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Lima | LIMA 29 | Peru | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Lima | Lima 32 | Peru | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Lima | LIMA 34 | Peru | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Bacolod | 6100 | Philippines | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Cebu City | 6000 | Philippines | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Davao City | 8000 | Philippines | Details | |
| Research Site | TERMINATED | Iloilo | 5000 | Philippines | Details | |
| Research Site | WITHDRAWN | Manila | 1000 | Philippines | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Quezon City | 1112 | Philippines | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | San Juan | Philippines | Details | ||
| Research Site | ACTIVE_NOT_RECRUITING | Biała Podlaska | 21-500 | Poland | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Białystok | 15-027 | Poland | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Bydgoszcz | 85-796 | Poland | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Koszalin | 75-581 | Poland | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Lublin | 20-090 | Poland | Details | |
| Research Site | TERMINATED | Rzeszów | 30-055 | Poland | Details | |
| Research Site | WITHDRAWN | Rzeszów | 35-021 | Poland | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Warszawa | 02-781 | Poland | Details | |
| Research Site | WITHDRAWN | Wroclaw | 53-413 | Poland | Details | |
| Research Site | WITHDRAWN | Łódź | 90-242 | Poland | Details | |
| Research Site | WITHDRAWN | Łódź | 92-213 | Poland | Details | |
| Research Site | WITHDRAWN | Moscow | 111123 | Russian Federation | Details | |
| Research Site | WITHDRAWN | Moscow | 115478 | Russian Federation | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Moscow | 117997 | Russian Federation | Details | |
| Research Site | WITHDRAWN | Moscow | 121205 | Russian Federation | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Moscow | 143423 | Russian Federation | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Saint Petersburg | 190020 | Russian Federation | Details | |
| Research Site | WITHDRAWN | Saint Petersburg | 194017 | Russian Federation | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Saint Petersburg | 197758 | Russian Federation | Details | |
| Research Site | WITHDRAWN | Saint Petersburg | 198217 | Russian Federation | Details | |
| Research Site | WITHDRAWN | Saint-Petersburg | 197758 | Russian Federation | Details | |
| Research Site | RECRUITING | Ar Riyāḑ | 11426 | Saudi Arabia | Details | |
| Research Site | RECRUITING | Dammam | 31444 | Saudi Arabia | Details | |
| Research Site | RECRUITING | Jeddah | 21423 | Saudi Arabia | Details | |
| Research Site | RECRUITING | Jeddah | 23214 | Saudi Arabia | Details | |
| Research Site | WITHDRAWN | Riyadh | 11525 | Saudi Arabia | Details | |
| Research Site | WITHDRAWN | Riyadh | 12987 | Saudi Arabia | Details | |
| Research Site | RECRUITING | Riyadh | 3354 | Saudi Arabia | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Barcelona | 08028 | Spain | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Barcelona | 08035 | Spain | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Madrid | 28007 | Spain | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Madrid | 28040 | Spain | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Sevilla | 41013 | Spain | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Vigo | 36312 | Spain | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Kaohsiung | 82445 | Taiwan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Taichung | 40443 | Taiwan | Details | |
| Research Site | WITHDRAWN | Tainan | 70403 | Taiwan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Tainan | 710 | Taiwan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Taipei 112 | Taiwan | Details | ||
| Research Site | ACTIVE_NOT_RECRUITING | Taipei City | 114 | Taiwan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Taipei | 100 | Taiwan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Taoyuan | 333 | Taiwan | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Bangkok | 10210 | Thailand | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Bangkok | 10330 | Thailand | Details | |
| Research Site | WITHDRAWN | Bangkok | 10330 | Thailand | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Bangkok | 10400 | Thailand | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Chiang Mai | 50200 | Thailand | Details | |
| Research Site | ACTIVE_NOT_RECRUITING | Hat Yai | 90110 | Thailand | Details | |
| Research Site | TERMINATED | Khon Kaen | 40002 | Thailand | Details |