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| NCT ID | NCT06065748 |
| Title | A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer) |
| Recruitment | Recruiting |
| Gender | both |
| Phase | Phase III |
| Variant Requirements | No |
| Sponsors | Hoffmann-La Roche |
| Indications | |
| Therapies | |
| Age Groups: | adult | senior |
| Covered Countries | USA | NZL | ITA | FRA | ESP | DEU | CAN | BEL | AUS |
| Facility | Status | City | State | Zip | Country | Details |
|---|---|---|---|---|---|---|
| Kaiser Permanente - Harbor City | RECRUITING | Harbor City | California | 90710 | United States | Details |
| USC Norris Comprehensive Cancer Center | RECRUITING | Los Angeles | California | 90033 | United States | Details |
| USC Norris Cancer Center; Oncology/Hematology - Newport Beach Treatment Center | RECRUITING | Newport Beach | California | 92663 | United States | Details |
| The Lundquist Institute for BioMedical Innovation at Harbor-UCLA Medical Cente | RECRUITING | Torrance | California | 90502 | United States | Details |
| Georgetown University Medical Center | RECRUITING | Washington | District of Columbia | 20007 | United States | Details |
| MedStar Washington Hosp Center | RECRUITING | Washington | District of Columbia | 20010 | United States | Details |
| Cancer Specialists of North Florida | RECRUITING | Jacksonville | Florida | 32256-6932 | United States | Details |
| New England Cancer Specialists | RECRUITING | Scarborough | Maine | 04074 | United States | Details |
| Frederick Health Hospital | RECRUITING | Frederick | Maryland | 21701 | United States | Details |
| Astera Cancer Care East Brunswick | RECRUITING | East Brunswick | New Jersey | 08816 | United States | Details |
| Asante Rogue Regional Medical Center | RECRUITING | Medford | Oregon | 97504-8332 | United States | Details |
| Ann B. Barshinger Cancer Institute | RECRUITING | Lancaster | Pennsylvania | 17604 | United States | Details |
| WellSpan Oncology Research | RECRUITING | York | Pennsylvania | 17403 | United States | Details |
| Avera Cancer Institute - Aberdeen | RECRUITING | Aberdeen | South Dakota | 57401 | United States | Details |
| Avera Cancer Institute | RECRUITING | Sioux Falls | South Dakota | 57105 | United States | Details |
| West Cancer Center | RECRUITING | Germantown | Tennessee | 38138 | United States | Details |
| Fundación CENIT para la Investigación en Neurociencias | RECRUITING | Buenos Aires | C1125ABD | Argentina | Details | |
| Inst. de Oncologia Angel H. Roffo ; Oncology Dept | RECRUITING | Buenos aires | C1417DTB | Argentina | Details | |
| Centro Oncologico Korben; Oncology | RECRUITING | Ciudad Autonoma Buenos Aires | C1426AGE | Argentina | Details | |
| Sanatorio Allende | RECRUITING | Cordoba | X5000JHQ | Argentina | Details | |
| Centro Oncologico Riojano Integral (CORI) | RECRUITING | La Rioja | F5300COE | Argentina | Details | |
| Hospital Alemán | RECRUITING | Recoleta | C1118AAT | Argentina | Details | |
| Instituto de Oncología de Rosario | RECRUITING | Rosario | S2000KZE | Argentina | Details | |
| Sanatorio Parque S.A. | RECRUITING | Rosario | S2000QGB | Argentina | Details | |
| Hospital Provincial del Centenario | RECRUITING | Rosario | S2002KDS | Argentina | Details | |
| Centro Oncológico de Excelencia | RECRUITING | San Juan | J5402BGA | Argentina | Details | |
| Northern Beaches Hospital | RECRUITING | Frenchs Forest | New South Wales | 2086 | Australia | Details |
| Nepean Hospital; Nepean Cancer Care Centre | RECRUITING | Kingswood | New South Wales | 2747 | Australia | Details |
| Mater Hospital; Patricia Ritchie Centre for Cancer Care and Research | RECRUITING | North Sydney | New South Wales | 2060 | Australia | Details |
| University of the Sunshine Coast | RECRUITING | Sippy Downs | Queensland | 4556 | Australia | Details |
| Mater Misericordiae Limited | RECRUITING | South Brisbane | Queensland | 4101 | Australia | Details |
| Cancer Research SA | RECRUITING | Adelaide | South Australia | 5000 | Australia | Details |
| Barwon Health | RECRUITING | Geelong | Victoria | 3220 | Australia | Details |
| Sunshine Hospital | RECRUITING | St Albans | Victoria | 3021 | Australia | Details |
| South West Healthcare | RECRUITING | Warrnambool | Victoria | 3280 | Australia | Details |
| Cliniques Universitaires St-Luc | RECRUITING | Bruxelles | 1200 | Belgium | Details | |
| UZ Gent | RECRUITING | Gent | 9000 | Belgium | Details | |
| UZ Leuven Gasthuisberg | RECRUITING | Leuven | 3000 | Belgium | Details | |
| CHU Sart-Tilman | RECRUITING | Liège | 4000 | Belgium | Details | |
| Clinique Ste-Elisabeth | RECRUITING | Namur | 5000 | Belgium | Details | |
| Sint Augustinus Wilrijk | RECRUITING | Wilrijk | 2610 | Belgium | Details | |
| Obras Sociais Irma Dulce - Osid | RECRUITING | Salvador | BA | 40415-006 | Brazil | Details |
| Crio - Centro Regional Integrado de Oncologia | RECRUITING | Fortaleza | CE | 60336-232 | Brazil | Details |
| CEDOES - Diagnóstico e Pesquisa | RECRUITING | Vitoria | ES | 29055-450 | Brazil | Details |
| Hospital Araujo Jorge; Departamento de Ginecologia E Mama | RECRUITING | Goiania | GO | 74605-070 | Brazil | Details |
| Hospital do Cancer de Pernambuco - HCP | RECRUITING | Recife | PE | 50040-000 | Brazil | Details |
| Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda | RECRUITING | Ijui | RS | 98700-000 | Brazil | Details |
| Santa Casa de Misericordia de Porto Alegre | RECRUITING | Porto Alegre | RS | 90020-090 | Brazil | Details |
| Hospital Moinhos de Vento | RECRUITING | Porto Alegre | RS | 90035-000 | Brazil | Details |
| Hospital Sao Lucas - PUCRS | RECRUITING | Porto Alegre | RS | 90610-000 | Brazil | Details |
| Hospital de Cancer de Barretos | RECRUITING | Barretos | SP | 14784-400 | Brazil | Details |
| Hospital Amaral Carvalho | RECRUITING | Jau | SP | 17210-120 | Brazil | Details |
| Hospital Sírio-Libanês | RECRUITING | Sao Paulo | SP | 01308-050 | Brazil | Details |
| Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda | RECRUITING | Sao Paulo | SP | 01317-001 | Brazil | Details |
| Hospital A. C. Camargo; Oncologia | RECRUITING | Sao Paulo | SP | 01509-010 | Brazil | Details |
| Royal Victoria Regional Health Centre | RECRUITING | Barrie | Ontario | L4M 6M2 | Canada | Details |
| Lakeridge Health Oshawa | RECRUITING | Oshawa | Ontario | L1G 2B9 | Canada | Details |
| North York General Hospital | RECRUITING | Toronto | Ontario | M2K 1E1 | Canada | Details |
| Princess Margaret Cancer Center | RECRUITING | Toronto | Ontario | M5G 2M9 | Canada | Details |
| CIUSSS du Saguenay Lac-Saint-Jean, Chicoutimi Hospital | RECRUITING | Chicoutimi | Quebec | G7H 5H6 | Canada | Details |
| CISSS Chaudière-Appalaches | RECRUITING | Levis | Quebec | G6V 3Z1 | Canada | Details |
| Centre Hospitalier de l'Universite de Montreal (CHUM) | RECRUITING | Montreal | Quebec | H2X 0C1 | Canada | Details |
| McGill University Health Centre - Glen Site | RECRUITING | Montreal | Quebec | H4A 3J1 | Canada | Details |
| CHU de Québec - Hôpital du Saint-Sacrement | RECRUITING | Quebec City | Quebec | G1S 4L8 | Canada | Details |
| Hopital regional de saint jerome | RECRUITING | Saint-jerome | Quebec | J7Z 5T3 | Canada | Details |
| Clínica Puerto Montt | RECRUITING | Puerto Montt | 5500243 | Chile | Details | |
| Oncovida | RECRUITING | Santiago | 7510032 | Chile | Details | |
| Centro De Cancer Universidad Catolica | RECRUITING | Santiago | 8330032 | Chile | Details | |
| Icegclinic | RECRUITING | Santiago | Chile | Details | ||
| Beijing Cancer Hospital | RECRUITING | Beijing | 100142 | China | Details | |
| the First Hospital of Jilin University; Cancer Center | RECRUITING | Changchun City | 130021 | China | Details | |
| Hunan Cancer Hospital | RECRUITING | Changsha CITY | 410013 | China | Details | |
| West China Hospital of Sichuan University | RECRUITING | Chengdu City | 610041 | China | Details | |
| Sichuan Provincial People's Hospital | RECRUITING | Chengdu | 610072 | China | Details | |
| The First Affiliated Hospital, Chongqing Medical University | RECRUITING | Chongqing | 400016 | China | Details | |
| Fujian Medical University Union Hospital | RECRUITING | Fuzhou City | 350001 | China | Details | |
| No. 900 Hospital (Fuzhou General Hospital) | RECRUITING | Fuzhou City | 350009 | China | Details | |
| Cancer Center, Sun Yat-sen University of Medical Sciences; Department of Medical Oncology | RECRUITING | Guangzhou City | 510060 | China | Details | |
| The Second Affiliated Hospital of Zhejiang University College | RECRUITING | Hangzhou | 310009 | China | Details | |
| Harbin Medical University Cancer Hospital | RECRUITING | Harbin | 150081 | China | Details | |
| Jinan Central Hospital | RECRUITING | Jinan City | 250013 | China | Details | |
| Shandong Cancer Hospital | RECRUITING | Jinan | 250117 | China | Details | |
| The First People's Hospital of Yunnan Province | RECRUITING | Kunming City | 650034 | China | Details | |
| The First Affiliated Hospital to Henan University of Science and Technology | RECRUITING | Luoyang City | 471031 | China | Details | |
| Guangxi Cancer Hospital of Guangxi Medical University | RECRUITING | Nanning City | 530021 | China | Details | |
| Fudan University Shanghai Cancer Center | RECRUITING | Shanghai City | 200120 | China | Details | |
| Shanxi Province Cancer Hospital | RECRUITING | Taiyuan City | 030013 | China | Details | |
| Taizhou Hospital of Zhejiang Province | RECRUITING | Taizhou | China | Details | ||
| Tianjin Cancer Hospital; Department of Breast Oncology | RECRUITING | Tianjin | 300000 | China | Details | |
| The Tumor Hospital of Xinjiang Medical University | RECRUITING | Urumqi | 830000 | China | Details | |
| Union Hospital Tongji Medical College Huazhong University of Science and Technology | RECRUITING | Wuhan City | 430023 | China | Details | |
| Hubei Cancer Hospital | RECRUITING | Wuhan | 430079 | China | Details | |
| The Second Affiliated Hospital of Xi'an Jiao Tong University | RECRUITING | Xi'an City | 710004 | China | Details | |
| Xi'an International Medical Center Hospital | RECRUITING | Xian | 710100 | China | Details | |
| The Affiliated Hospital of Xuzhou Medical University | RECRUITING | Xuzhou | China | Details | ||
| Zhejiang Cancer Hospital | RECRUITING | Zhejiang | 310022 | China | Details | |
| The First Affiliated Hospital of Zhengzhou University | RECRUITING | Zhengzhou | 450052 | China | Details | |
| Fundación CTIC - Centro de Tratamiento e Investigación sobre Cáncer Luis Carlos Sarmiento Angulo | RECRUITING | Bogota, D.C. | 110131 | Colombia | Details | |
| Oncomedica S.A. | RECRUITING | Monteria | 230002 | Colombia | Details | |
| Sociedad de Oncología y hematología del Cesar Ltda | RECRUITING | Valledupar | 200001 | Colombia | Details | |
| Clinica CIMCA | RECRUITING | San José | 10103 | Costa Rica | Details | |
| ICIMED Instituto de Investigación en Ciencias Médicas | RECRUITING | San José | 10108 | Costa Rica | Details | |
| Proclinical Pharma | RECRUITING | San José | 11303 | Costa Rica | Details | |
| Institut Sainte Catherine | RECRUITING | Avignon | 84082 | France | Details | |
| HOPITAL JEAN MINJOZ; Oncologie | RECRUITING | Besancon | 25030 | France | Details | |
| Centre Hospitalier Saint Louis; Oncologie Medicale | RECRUITING | La Rochelle | 17019 | France | Details | |
| Centre Leon Berard; Departement Oncologie Medicale | RECRUITING | Lyon | 69373 | France | Details | |
| Centre Cancerologie Grand Montpellier | RECRUITING | Montpellier | 34070 | France | Details | |
| Institut Jean Godinot; Oncologie Medicale | RECRUITING | Reims CEDEX | 51056 | France | Details | |
| IUCT Oncopole | RECRUITING | Toulouse | 31100 | France | Details | |
| Gustave Roussy | RECRUITING | Villejuif | 94805 | France | Details | |
| St. Elisabeth Krankenhaus Köln GmbH; Gynäkologie und Geburtshilfe | RECRUITING | Koeln | 50935 | Germany | Details | |
| Celan S.A. | RECRUITING | Ciudad de Guatemala | 01010 | Guatemala | Details | |
| INTEGRA Cancer Institute | RECRUITING | Ciudad de Guatemala | 01010 | Guatemala | Details | |
| Sanatorio MEDIK-Cayala | RECRUITING | Ciudad de Guatemala | 01016 | Guatemala | Details | |
| Grupo Angeles | RECRUITING | Guatemala City | 01015 | Guatemala | Details | |
| Oncomedica | RECRUITING | Guatemala | 01010 | Guatemala | Details | |
| Centro Medico Integral de Cancerologia CEMIC | RECRUITING | Quetzaltenango | 09001 | Guatemala | Details | |
| Queen Mary Hospital; Dept of Medicine | RECRUITING | Hong Kong | Hong Kong | Details | ||
| B-A-Z Vármegyei Központi Kórház és Egyetemi Oktatókórház; Klin. Onkológiai és Sugárterápiás Centrum | RECRUITING | Miskolc | 3526 | Hungary | Details | |
| Nograd Varmegyei Szent Lazar Korhaz; Onkologiai es Sugarterapias Centrum | RECRUITING | Salgótarján | 3100 | Hungary | Details | |
| Grant Medical Foundation, Ruby Hall Clinic | RECRUITING | Pune | Maharashtra | 411001 | India | Details |
| Hadassah Ein Karem Hospital; Oncology Dept | RECRUITING | Jerusalem | 9112000 | Israel | Details | |
| Rabin Medical Center; Oncology Dept | RECRUITING | Petah Tikva | 4910000 | Israel | Details | |
| Sheba MC | RECRUITING | Ramat Gan | 5265601 | Israel | Details | |
| Sourasky Medical Center; Oncology Department | RECRUITING | Tel-Aviv | 6423900 | Israel | Details | |
| Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati | ACTIVE_NOT_RECRUITING | Avellino | Campania | 83100 | Italy | Details |
| Policlinico S.Orsola-Malpighi; Istituto Oncologia R. Addarii | RECRUITING | Bologna | Emilia-Romagna | 40138 | Italy | Details |
| I.R.S.T Srl IRCCS; Oncologia Medica | RECRUITING | Meldola | Emilia-Romagna | 47014 | Italy | Details |
| Policlinico Universitario Agostino Gemelli | ACTIVE_NOT_RECRUITING | Roma | Lazio | 00168 | Italy | Details |
| Università Campus Bio-Medico di Roma; Oncologia Medica | RECRUITING | Roma | Lazio | 128 | Italy | Details |
| ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica | RECRUITING | Brescia | Lombardia | 25123 | Italy | Details |
| Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1 | RECRUITING | Milano | Lombardia | 20133 | Italy | Details |
| Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia | RECRUITING | Rozzano | Lombardia | 20089 | Italy | Details |
| A.O.U. Maggiore della Carità | RECRUITING | Novara | Piemonte | 28100 | Italy | Details |
| Presidio Ospedaliero di Summa-Perrino; Oncologia Medica | RECRUITING | Brindisi | Puglia | 72100 | Italy | Details |
| Humanitas Centro Catanese Di Oncologia; Oncologia Medica | RECRUITING | Misterbianco (CT) | Sicilia | 95045 | Italy | Details |
| Azienda Ospedaliera Universitaria Careggi | RECRUITING | Florence | Toscana | 50134 | Italy | Details |
| IOV - Istituto Oncologico Veneto - IRCCS; Oncologia Medica II | RECRUITING | Padova | Veneto | 35128 | Italy | Details |
| Kyungpook National University Chilgok Hospital | RECRUITING | Daegu | 41404 | Korea, Republic of | Details | |
| Seoul National University Bundang Hospital | ACTIVE_NOT_RECRUITING | Seongnam-si | 463-707 | Korea, Republic of | Details | |
| Korea University Anam Hospital | RECRUITING | Seoul | 02841 | Korea, Republic of | Details | |
| Seoul National University Hospital | RECRUITING | Seoul | 03080 | Korea, Republic of | Details | |
| Severance Hospital, Yonsei University Health System; Clinical Pharmacy | RECRUITING | Seoul | 03722 | Korea, Republic of | Details | |
| Asan Medical Center | RECRUITING | Seoul | 05505 | Korea, Republic of | Details | |
| Gangnam Severance Hospital | RECRUITING | Seoul | 06273 | Korea, Republic of | Details | |
| Samsung Medical Center | ACTIVE_NOT_RECRUITING | Seoul | 06351 | Korea, Republic of | Details | |
| Ewha Womans University Mokdong Hospital | RECRUITING | Seoul | 07985 | Korea, Republic of | Details | |
| Ulsan University Hosiptal | RECRUITING | Ulsan | 44033 | Korea, Republic of | Details | |
| Palmerston North Hospital; Regional Cancer Treatment Service | RECRUITING | Palmerston North | 4442 | New Zealand | Details | |
| Instytut "Centrum Zdrowia Matki Polki"; Klinika Onkologii | RECRUITING | ?ód? | 93-338 | Poland | Details | |
| Szpital Morski Im. Pck; Oncology & Radiotherapy Dept | RECRUITING | Gdynia | 81-519 | Poland | Details | |
| Przychodnia Lekarska KOMED, Roman Karaszewski | RECRUITING | Konin | 62-500 | Poland | Details | |
| Mazowiecki Szpital Wojewódzki im. ?w. Jana Paw?a II; Oddzial Onkologii Klinicznej i Radioterapii | RECRUITING | Siedlce | 08-110 | Poland | Details | |
| IPO de Coimbra; Servico de Oncologia Medica | RECRUITING | Coimbra | 3000-075 | Portugal | Details | |
| Hospital de S. Francisco Xavier; Unidade de Oncologia Medica | RECRUITING | Lisboa | 1495-005 | Portugal | Details | |
| Hospital da Luz; Departamento de Oncologia Medica | RECRUITING | Lisboa | 1500-650 | Portugal | Details | |
| IPO do Porto; Servico de Oncologia Medica | RECRUITING | Porto | 4200-072 | Portugal | Details | |
| CHVNG/E_Unidade 1; Servico de Oncologia Medica | RECRUITING | Vila Nova de Gaia | 4434-502 | Portugal | Details | |
| Institut Catala d?Oncologia Hospital Germans Trias i Pujol | RECRUITING | Badalona | Barcelona | 08916 | Spain | Details |
| Hospital Univ Vall d'Hebron; Servicio de Oncologia | RECRUITING | Sant Andreu de La Barca | Barcelona | 08740 | Spain | Details |
| Hospital de Jerez de la Frontera; Servicio de Oncologia | RECRUITING | Jerez de La Frontera | Cadiz | 11407 | Spain | Details |
| Hospital Quiron de Madrid; Servicio de Oncologia | RECRUITING | Pozuelo de Alarcon | Madrid | 28223 | Spain | Details |
| Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia | RECRUITING | El Palmar | Murcia | 30120 | Spain | Details |
| Hospital Alvaro Cunqueiro; Servicio de Oncologia | RECRUITING | Vigo | Pontevedra | 36213 | Spain | Details |
| Hospital Universitari Dexeus - Grupo Quironsalud; Servicio de Oncologia Medica | RECRUITING | Barcelona | 08028 | Spain | Details | |
| Hospital Juan Ramon Jimenez;Servicio de Oncologia | RECRUITING | Huelva | 21005 | Spain | Details | |
| Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia | RECRUITING | Jaen | 23007 | Spain | Details | |
| Centro Oncologico MD Anderson Internacional; Servicio de Oncologia | RECRUITING | Madrid | 28033 | Spain | Details | |
| HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia | RECRUITING | Madrid | 28050 | Spain | Details | |
| Hospital Universitario Virgen Macarena; Servicio de Oncologia | RECRUITING | Sevilla | 41009 | Spain | Details | |
| Hospital Universitario Virgen del Rocio; Servicio de Oncologia | RECRUITING | Sevilla | 41013 | Spain | Details | |
| Instituto Valenciano Oncologia; Oncologia Medica | RECRUITING | Valencia | 46009 | Spain | Details | |
| Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia | RECRUITING | Valencia | 46015 | Spain | Details | |
| Hsin-Chu Branch of National Taiwan University Hospital | RECRUITING | Hsinchu City | 300 | Taiwan | Details | |
| China Medical University Hospital; Surgery | RECRUITING | Taichung | 404 | Taiwan | Details | |
| Koo Foundation Sun Yat-Sen Cancer Center; Hemato-Oncology | RECRUITING | Taipei City | 11259 | Taiwan | Details | |
| VETERANS GENERAL HOSPITAL; Department of General Surgery | RECRUITING | Taipei | 00112 | Taiwan | Details | |
| National Taiwan Uni Hospital; Dept of Oncology | RECRUITING | Taipei | 100 | Taiwan | Details | |
| Veterans General Hospital - Taichung | RECRUITING | Xitun Dist. | 40705 | Taiwan | Details | |
| Maharaj Nakorn Chiang Mai Hospital; Depart of Radiology; Divis of Therapeutic Radiology and Oncology | RECRUITING | Muang Chiang MAI Delivery Branch 3 | 50200 | Thailand | Details | |
| Songklanagarind Hospital; Department of Oncology | RECRUITING | Songkhla | 90110 | Thailand | Details |