Drug Class Detail

Drug Class AKT Inhibitor (Pan) - ATP competitive

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Drug Name Trade Name Synonyms Drug Classes Drug Description
LYS6KAKT1 Akt Inhibitor (Pan) 17 AKT Inhibitor (Pan) - ATP competitive 7 S6 Kinase Inhibitor 5 LYS6KAKT1 is an ATP-competitive inhibitor of AKT and p70 S6 kinases, which prevents signaling of the PI3K/AKT pathway and may result in decreased tumor volume and slowed tumor growth (Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B117).
AT-7867 AT7687 Akt Inhibitor (Pan) 17 AKT Inhibitor (Pan) - ATP competitive 7 PKA Inhibitor 2 S6 Kinase Inhibitor 5 AT7867 is an ATP-competitive inhibitor of AKT1, AKT2, AKT3, PKA, and P70S6K, which inhibits cell proliferation and tumor growth (PMID: 20423992).
AT13148 AKT Inhibitor (Pan) - ATP competitive 7 PKA Inhibitor 2 AT13148 is a small molecule ATP-competitive inhibitor of AGC kinases including AKT1, AKT2, AKT3, p70S6K (RPS6KB1), PKA (PRKACA), ROCK1, ROCK2, RSK1, and SGK3, which results in decreased growth of tumor cells (PMID: 22781553, PMID: 25840982).
Afuresertib GSK2110183 Akt Inhibitor (Pan) 17 AKT Inhibitor (Pan) - ATP competitive 7 Afuresertib (GSK2110183) is a pan-AKT, ATP-competitive inhibitor, which may result in inhibition of the PI3K/AKT signaling pathway and tumor cell proliferation, and induction of tumor cell apoptosis (PMID: 25075128).
GSK690693 AKT Inhibitor (Pan) - ATP competitive 7 GSK690693 is a ATP-competitive pan-AKT inhibitor, which inhibits AKT signaling, resulting in decreased proliferation and increased apoptosis of tumor cells (PMID: 18381444).
CCT129254 AT11854 AKT Inhibitor (Pan) - ATP competitive 7 CCT129254 is a small molecule ATP-competitive inhibitor of AKT and Rho kinases, which results in decreased tumor cell migration and metastasis (PMID: 25840982).
Uprosertib GSK2141795 Akt Inhibitor (Pan) 17 AKT Inhibitor (Pan) - ATP competitive 7 Uprosertib (GSK2141795) is an ATP-competitive inhibitor of AKT, which leads to inhibition of PI3K/AKT signaling potentially resulting in inhibition of cell proliferation and anti-tumor growth (PMID: 24978597).
Molecular Profile Protein Effect Treatment Approaches