Drug Class Detail

Drug Class ATR Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
VX-970 VE-822|M6620 ATR Inhibitor 9 VX-970 is a small molecule inhibitor of ATR, which may enhance the sensitivity of chemotherapeutic agents resulting in antitumor activity (PMID: 25269479).
BEZ235 NVP-BEZ235|Dactolisib ATR Inhibitor 9 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 BEZ235 inhibits PI3K kinase, mTOR kinase, and ATR, which may result in tumor cell apoptosis and growth inhibition of tumor cells (PMID: 18606717, PMID: 21552262).
VE-821 ATR Inhibitor 9 VE-821 is a small molecule inhibitor of ATR, which may inhibit cell growth and enhance the sensitivity of chemotherapeutics (PMID: 22825331).
AZ20 ATR Inhibitor 9 AZ20 is a small molecule inhibitor of ATR, which may inhibit tumor growth and induce cell death (Cancer Res April 15, 2012 72; 1823).
ETP-46464 ATR Inhibitor 9 ETP-46464 inhibits ATR, potentially resulting in increased tumor cell sensitivity to other anti-cancer agents (PMID: 25560806, PMID: 21552262).
AZD6738 ATR Inhibitor 9 AZD6738 is an inhibitor of ATR, which may enhance the sensitivity of chemotherapeutic agents, potentially resulting in tumor regression (PMID: 26517239).
BAY1895344 ATR Inhibitor 9 BAY1895344 is a selective Atr inhibitor that inhibits proliferation of a variety of tumor cells (Proceedings of the AACR, Vol 58, Apr 2017, Abstract 983).
Torin 2 ATM Inhibitor 6 ATR Inhibitor 9 mTOR Inhibitor 48 Torin 2 inhibits ATM, ATR and mTOR signaling through mTORC1/2, thereby preventing cell proliferation (PMID: 21322566, PMID: 23436801).
NU6027 ATR Inhibitor 9 NU6027 is a small molecule inhibitor of ATR, which may enhance the sensitivity of chemotherapeutic agents and result in decreased cell survival (PMID: 21730979).
Molecular Profile Protein Effect Treatment Approaches