Drug Class Detail

Drug Class AURK Inhibitor (Pan)


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Drug Name Trade Name Synonyms Drug Classes Drug Description
AMG 900 AMG900|AMG-900 AURK Inhibitor (Pan) 11 AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases (PMID: 25367255).
SNS-314 AURK Inhibitor (Pan) 11 SNS-314 is a pan-Aurora kinase inhibitor, which prevents cell division and proliferation (PMID: 18678489).
CCT137690 AURK Inhibitor (Pan) 11 CCT137690 selectively inhibits aurora kinases (AURKA, AURKB, and AURKC) with nanomolar affinities (PMID: 20565112).
Danusertib PHA-739358 ABL1 Inhibitor 4 AURK Inhibitor (Pan) 11 BCR-ABL Inhibitor 23 FGFR1 Inhibitor 21 RET Inhibitor 36 TrkA Receptor Inhibitor 7 Danusertib (PHA-739358) is a pan-Aurora kinase with additional activity against ABL, FGFR1, RET, TRKA, and BCR-ABL, including the T315I mutant (PMID: 20072840, PMID: 18089710).
CCT129202 AURK Inhibitor (Pan) 11 CCT129202 is a pan-Aurora A,B,C kinase inhibitor, which induces cell proliferation (PMID: 18089709).
BI-847325 BI 847325|BI847325 AURK Inhibitor (Pan) 11 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 BI-847325 is a dual pan-MEK/Aurora inhibitor, with specific activity against MEK 1 and 2, and Aurora kinases A, B, and C (PMID: 27496137).
Tozasertib MK-0457|VX-680 AURK Inhibitor (Pan) 11 BCR-ABL Inhibitor 23 Tozasertib (VX-680) is a pan-AURK inhibitor with increased potency against Aurora kinase A (AURKA), and has additional activity against BCR-ABL, potentially resulting in decreased tumor growth (PMID: 14981513, PMID: 22772060).
Reversine AURK Inhibitor (Pan) 11 MPS1 Inhibitor 24 Reversine is an A3 adenosine receptor antagonist and pan-Aurora kinase and TTK (MPS1) inhibitor, which prevents cell proliferation (PMID: 14719906, PMID: 18483302, PMID: 25043312).
Cenisertib AS703569 AURK Inhibitor (Pan) 11 FLT3 Inhibitor 48 Cenisertib (AS703569) is a pan-Aurora kinase inhibitor with additional activity against Flt3 to prevent cell proliferation (PMID: 19609559).
PHA-680632 PHA680632 AURK Inhibitor (Pan) 11 PHA-680632 is a pan-Aurora A,B, C kinase inhibitor, which inhibits cell proliferation (PMID: 16818708).
ABT-348 ilorasertib AURK Inhibitor (Pan) 11 PDGFR Inhibitor (Pan) 27 VEGFR Inhibitor (Pan) 30 Ilorasertib (ABT-348) is an ATP-competitive multitargeted kinase inhibitor with activity towards Aurora kinases, and VEGFR, and PDGFR kinase families (PMID: 22935731).
Molecular Profile Protein Effect Treatment Approaches