Drug Class Detail

Drug Class Aurkb Inhibitors

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
BRD-7880 Aurkb Inhibitors 17 Aurkc Inhibitors 2 BRD-7880 selectively inhibits Aurora kinase B and C, resulting in growth inhibition in tumor cells (PMID: 26928769).
Barasertib AZD1152 Aurkb Inhibitors 17 Barasertib (AZD1152) is a selective Aurora B kinase inhibitor, which induces cell cycle arrest (PMID: 17495131).
Aurora Kinase Inhibitor II AI II Aurka Inhibitors 23 Aurkb Inhibitors 17 Aurora Kinase Inhibitor II (AI II) inhibits Aurora kinase A and B, which potentially results in reduced tumor cell proliferation and increased tumor cell death (PMID: 16337122, PMID: 26842935).
ZM447439 ZM 447439 Aurka Inhibitors 23 Aurkb Inhibitors 17 ZM447439 inhibits Aurora Kinase A and B, resulting in increased tumor cell death (PMID: 26732741, PMID: 24152827).
TAK-901 Aurkb Inhibitors 17 FGFR2 Inhibitor 15 FLT3 Inhibitor 48 TAK-901 is a selective inhibitor of Aurora B kinase, FLT3, and FGFR2, and has demonstrated anti-tumor activity in several cancer models (PMID: 23358665).
AZD2811 Aurkb Inhibitors 17 AZD2811 is nanoparticle formulation of Barasertib (AZD1152), which inhibits Aurora kinase B to induce cell cycle arrest and results in tumor regression (PMID: 26865565, PMID: 28292940).
PF-03814735 Aurka Inhibitors 23 Aurkb Inhibitors 17 PF-03814735 is an inhibitor of Aurora kinases A and B, which prevents cell division and proliferation (PMID: 20354118).
AJI-100 Aurka Inhibitors 23 Aurkb Inhibitors 17 JAK2 Inhibitor 17 AJI-100 is a dual-AURKA/B, JAK2 inhibitor, which prevents cell growth and induces apoptosis (PMID: 24930769, PMID: 28077684).
Chiauranib CS2164 Aurkb Inhibitors 17 CSF1R Inhibitor 22 KIT Inhibitor 48 PDGFR-alpha Inhibitor 7 VEGFR Inhibitor (Pan) 30 Chiauranib (CS2164) is a multi-kinase inhibitor that inhibits AURKB, CSF-1R, VEGFRs, KIT, and PDGFRA, resulting in decreased tumor growth and angiogenesis (PMID: 28004478).
BMS-754807 ALK Inhibitor 19 Aurka Inhibitors 23 Aurkb Inhibitors 17 IGF-1R Inhibitor 17 MET Inhibitor 50 TrkA Receptor Inhibitor 7 BMS-754807 is a multi-kinase inhibitor with activity against IGF-1R, insulin receptor, MET, ALK, TRKA, TRKB, AURKA, and AURKB, potentially resulting in decreased tumor cell proliferation (PMID: 25748921).
TY-011 Aurka Inhibitors 23 Aurkb Inhibitors 17 VEGFR2 Inhibitor 34 TY-011 inhibits Aurora kinase A and B, as well as KDR (VEGFR2), resulting in inhibition growth and angiogenesis in tumors (PMID: 27887633).
AJI-214 Aurka Inhibitors 23 Aurkb Inhibitors 17 JAK2 Inhibitor 17 AJI-214 is a dual-AURKA/B, JAK2 inhibitor, which prevents cell growth and induces apoptosis (PMID: 24930769, PMID: 28077684).
CYC116 Aurka Inhibitors 23 Aurkb Inhibitors 17 CYC116 is an Aurora A, B kinase inhibitor, which inhibits cell proliferation (PMID: 20462263).
JNJ-7706621 Aurka Inhibitors 23 Aurkb Inhibitors 17 CDK1 Inhibitor 12 CDK2 Inhibitor 16 JNJ-7706621 is a dual inhibitor of CDK1/2 and AURKA, B, which induces cell cycle arrest (PMID: 16204078).
KW-2450 Aurka Inhibitors 23 Aurkb Inhibitors 17 IGF-1R Inhibitor 17 KW-2450 is a multitargeted kinase inhibitor with activity against Aurora A and B, and IGF-1R, which potentially results in decreased tumor cell growth (PMID: 26443806).
AT9283 ABL1 Inhibitor 4 Aurka Inhibitors 23 Aurkb Inhibitors 17 JAK2 Inhibitor 17 JAK3 Inhibitor 4 AT9283 is a dual inhibitor of JAK 2 and 3 kinases, Aurora kinases A and B, and has activity against Abl T315I (PMID: 19143567).
GSK1070916 GSK1070916A Aurkb Inhibitors 17 Aurkc Inhibitors 2 GSK1070916 is a selective inhibitor of Aurora B/C kinases, which induces inhibition of tumor cell proliferation in culture and in xenograft models (PMID: 19567821).
Molecular Profile Protein Effect Treatment Approaches