Drug Class Detail

Drug Class BCL-XL inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Navitoclax ABT-263 BCL-XL inhibitor 9 BCL2 inhibitor 15 Navitoclax (ABT-263) is a BCL2, BCL-XL, and BCL-W inhibitor, which may enhance the efficacy of chemotherapeutics (PMID: 25787766).
A-1155463 BCL-XL inhibitor 9 A-1155463 inhibits BCL-XL, resulting in apoptosis in BCL-XL dependent tumor cells (PMID: 25787766).
TW-37 BCL-XL inhibitor 9 BCL2 inhibitor 15 MCL1 Inhibitor 12 TW-37 is a third-generation BH3 mimetic that inhibits BCL2, MCL1, and with lesser affinity, BCL-XL, which may result in increased tumor cell apoptosis and increased sensitivity to chemotherapeutics (PMID: 17404107).
APG-1252 BM-1252 BCL-XL inhibitor 9 BCL2 inhibitor 15 APG-1252 inhibits BCL2 and BCL-XL, potentially resulting in increased tumor cell apoptosis and decreased tumor growth (Eur J Cancer, 2014, Vol 50 , pp.109-10).
S44563 BCL-XL inhibitor 9 BCL2 inhibitor 15 S44563 binds to BCL-2 and BCL-XL and inhibits their interaction with BH3, which potentially results in increased tumor cell apoptosis and decreased tumor growth (PMID: 24454684).
ABT-737 BCL-XL inhibitor 9 BCL2 inhibitor 15 ABT-737 is a BH3 mimetic, which targets Bcl2, Bcl-xl, and Bcl-w to induce apoptosis (NCI Drug Dictionary).
A-1331852 BCL-XL inhibitor 9 A-1331852 inhibits BCL-XL, resulting in increased tumor cell apoptosis and decreased tumor growth (PMID: 25787766).
WEHI-539 BCL-XL inhibitor 9 WEHI-539 is a selective inhibitor of BCL-XL that stimulates apoptotic responses in cells, resulting in killing of tumor cells (PMID: 23603658).
BM-1197 BCL-XL inhibitor 9 BCL2 inhibitor 15 BM-1197 is a dual inhibitor of BCL2 and BCL-XL, which may result in increased apoptosis and decreased tumor growth (PMID: 24901320).
Molecular Profile Protein Effect Treatment Approaches