Drug Class Detail

Drug Class BCL2 Family Inhibitor


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Obatoclax GX015-070 BCL2 Family Inhibitor 6 Obatoclax (GX015-070) is a pan-BCL2 family inhibitor, which leads to induction of tumor cell apoptosis (PMID: 18040043, PMID: 17332241).
Sabutoclax BI-97C1 BCL2 Family Inhibitor 6 Sabutoclax is a Pan-BCL2 family inhibitor, which inhibits BCL-2, BCL-XL, MCL-1, and BFL-1, resulting in decreased tumor cell growth (PMID: 20443627).
AT-101 R-(-)-gossypol acetic acid  BCL2 Family Inhibitor 6 AT-101 is a pan-BCL2 inhibitor that inhibits the anti-apoptotic proteins BCL2, BCL-XL, and MCL1, potentially resulting in increased tumor cell apoptosis and decreased cell proliferation (PMID: 26089640, PMID: 16611409).
Paclitaxel Taxol 7-Epipaclitaxel Antimicrotubule Agent 11 BCL2 Family Inhibitor 6 Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).
(-)BI97D6 BCL2 Family Inhibitor 6 (-)BI97D6 is a pan-BCL2 family inhibitor, which inhibits BCL-2, MCL1, BCL-XL, and BFL1, resulting in increased tumor cell apoptosis (PMID: 26045609).
Ch282-5 BCL2 Family Inhibitor 6 Ch282-5 is a gossypol derivative that binds to and inhibits BCL2, family proteins, resulting in decreased tumor cell growth and increased sensitivity to chemotherapeutic agents (PMID: 26515494).
Molecular Profile Protein Effect Treatment Approaches