Drug Class Detail

Drug Class CDK2 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PHA-533533 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK5 Inhibitor 6 GSK-3beta Inhibitor 3 PHA-533533 is an inhibitor of CDK1, CDK2, CDK4, CDK5, and GSK3B, which inhibits phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 15828833, PMID: 24004674).
JNJ-7706621 Aurka Inhibitors 23 Aurkb Inhibitors 17 CDK1 Inhibitor 12 CDK2 Inhibitor 16 JNJ-7706621 is a dual inhibitor of CDK1/2 and AURKA, B, which induces cell cycle arrest (PMID: 16204078).
Alvocidib flavopiridol|HMR 1275|L-868275|DSP-2033 CDK Inhibitor (Pan) 3 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK6 Inhibitor 3 CDK7 Inhibitor 9 CDK9 Inhibitor 12 Alvocidib (flavopiridol) is an inhibitor of CDK1, CDK2, CDK4, CDK6, CDK7, and CDK9, which may induce cell cycle arrest and apoptosis in cancer cells (PMID: 12165651, PMID: 8674031, PMID: 24470357).
FN-1501 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK6 Inhibitor 3 FLT3 Inhibitor 48 FN-1501 inhibits FLT3, CDK2, CDK4, and CDK6, resulting in decreased downstream signaling and potentially leading to reduced tumor cell proliferation and tumor growth (PMID: 29357250).
Purvalanol A CDK2 Inhibitor 16 CDK4 Inhibitor 12 Purvalanol A inhibits CDC2, CDK2, and CDK4, which may promote cell cycle arrest and induction of apoptosis in cancer cells (PMID: 9677190, PMID: 24190492).
Milciclib PHA-848125AC CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK5 Inhibitor 6 CDK7 Inhibitor 9 TrkA Receptor Inhibitor 7 Milciclib (PHA-848125AC) is a TRKA inhibitor with additional activity against CDK1, CDK2, CDK4, CDK5, and CDK7, potentially resulting in decreased tumor cell growth (PMID: 22160853).
Seliciclib Roscovitine CYC202 CDK2 Inhibitor 16 CDK5 Inhibitor 6 Roscovotine (seliciclib) inhibits Cdc2, Cdk2 and Cdk5, which results in disruption of cell-cycle progression and decreased cell proliferation (PMID: 9030781, PMID: 9366565)
SNS-032 BMS-387032 CDK2 Inhibitor 16 CDK7 Inhibitor 9 CDK9 Inhibitor 12 GSK-3alpha Inhibitor 1 SNS-032 (BMS-387032) is an inhibitor of CDK2, CDK7, CDK9, and GSK3A, which may promote cell cycle arrest and induction of apoptosis in cancer cells (PMID: 19169685).
TG02 SB1317 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK5 Inhibitor 6 CDK7 Inhibitor 9 CDK9 Inhibitor 12 FLT3 Inhibitor 48 JAK2 Inhibitor 17 TG02 is a pyrimidine-based molecule that inhibits CDK1, CDK2, CDK3, CDK5, CDK7, CDK9, JAK2, and FLT3, which results in growth inhibition in tumor cells (PMID: 21860433).
SU 9516 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 SU 9516 is an inhibitor of CDK1, CDK2, and CDK4, which inhibits phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 11507069).
CYC065 CDK2 Inhibitor 16 CDK9 Inhibitor 12 CYC065 inhibits CDK2 and CDK9, potentially resulting in decreased tumor cell growth (PMID: 28376145, PMID: 27351214).
Dinaciclib SCH727965 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK5 Inhibitor 6 CDK9 Inhibitor 12 Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 24900195, PMID: 24004674, PMID: 27880910).
AT7519 AT7519M CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK4/6 Inhibitor 8 CDK5 Inhibitor 6 CDK6 Inhibitor 3 CDK9 Inhibitor 12 AT7519 is an ATP competitive inhibitor of CDK1, CDK2, CDK4, CDK5, CDK6, and CDK9, which may induce cell cycle arrest and apoptosis in cancer cells (PMID: 19174555).
AZD5438 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK9 Inhibitor 12 AZD5438 is an inhibitor of CDK1, CDK2, and CDK9, which may promote cell cycle arrest and induction of apoptosis in cancer cells (PMID: 19509270).
R547 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 R547 is a small molecule that selectively inhibits cyclin-dependent kinases, leading to cell cycle arrest and apoptosis in cancer cells (PMID: 17121911).
ZK 304709 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK7 Inhibitor 9 CDK9 Inhibitor 12 PDGFR-beta Inhibitor 13 VEGFR Inhibitor (Pan) 30 ZK 304709 is a small molecule kinase inhibitor of CDKs 1, 2, 4, 7, and 9, VEGFR-1,2,3, and PDGFR-beta, which may result in inhibition of both the cell cycle and angiogenesis (PMID: 18653327).
Molecular Profile Protein Effect Treatment Approaches