Drug Class Detail

Drug Class CDK5 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PHA-533533 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK5 Inhibitor 6 GSK-3beta Inhibitor 3 PHA-533533 is an inhibitor of CDK1, CDK2, CDK4, CDK5, and GSK3B, which inhibits phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 15828833, PMID: 24004674).
Seliciclib Roscovitine CYC202 CDK2 Inhibitor 16 CDK5 Inhibitor 6 Roscovotine (seliciclib) inhibits Cdc2, Cdk2 and Cdk5, which results in disruption of cell-cycle progression and decreased cell proliferation (PMID: 9030781, PMID: 9366565)
TG02 SB1317 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK5 Inhibitor 6 CDK7 Inhibitor 9 CDK9 Inhibitor 12 FLT3 Inhibitor 48 JAK2 Inhibitor 17 TG02 is a pyrimidine-based molecule that inhibits CDK1, CDK2, CDK3, CDK5, CDK7, CDK9, JAK2, and FLT3, which results in growth inhibition in tumor cells (PMID: 21860433).
AT7519 AT7519M CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK4/6 Inhibitor 8 CDK5 Inhibitor 6 CDK6 Inhibitor 3 CDK9 Inhibitor 12 AT7519 is an ATP competitive inhibitor of CDK1, CDK2, CDK4, CDK5, CDK6, and CDK9, which may induce cell cycle arrest and apoptosis in cancer cells (PMID: 19174555).
Dinaciclib SCH727965 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK5 Inhibitor 6 CDK9 Inhibitor 12 Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 24900195, PMID: 24004674, PMID: 27880910).
Milciclib PHA-848125AC CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK4 Inhibitor 12 CDK5 Inhibitor 6 CDK7 Inhibitor 9 TrkA Receptor Inhibitor 7 Milciclib (PHA-848125AC) is a TRKA inhibitor with additional activity against CDK1, CDK2, CDK4, CDK5, and CDK7, potentially resulting in decreased tumor cell growth (PMID: 22160853).
Molecular Profile Protein Effect Treatment Approaches