Drug Class Detail

Drug Class CHK1 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
UCN-01 sc-3510|7-hydroxystaurosporine CDK Inhibitor (Pan) 3 CHK1 Inhibitor 14 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 PKC Inhibitor (Pan) 9 UCN-01 (sc-3510) is a derivative of staurosporine that inhibits CHK1 and PKC, with higher potency toward PKC-alpha, PKC-beta, and PKC-gamma, and also modulates CDK activity through upregulation of CDK inhibitors, potentially resulting in inhibition of tumor growth (PMID: 8022414, PMID: 15831461, PMID: 15150122).
CBP501 CHK1 Inhibitor 14 CBP501 is a peptide drug that inhibits the activity of several kinases responsible for phosphorylation of CDC25C, including MAPKAP-K2, C-Tak1, and CHK1, resulting in disruption of the G2 checkpoint and potentially leading to cell-cycle arrest and increased tumor cell death (PMID: 17237275).
MU380 CHK1 Inhibitor 14 MU380 is a selective inhibitor of CHK1, which increases sensitivity of tumor cells to DNA damaging agents, potentially resulting in decreased tumor growth (PMID: 28619751).
V158411 CHK1 Inhibitor 14 V158411 is a small molecule that selectively inhibits CHK1, which results in increased DNA damage, and potentially leads to decreased growth of tumor cells (PMID: 27829224, PMID: 24913641).
Prexasertib LY2606368|IC-83 CHK1 Inhibitor 14 Prexasertib (LY2606368) inhibits checkpoint kinase 1 (Chk1), which may result in accumulation of DNA damage and decreased tumor growth (PMID: 26141948, PMID: 28270495).
PF-00477736 PF-477736 CHK1 Inhibitor 14 PF-00477736 is an ATP-competitive inhibitor of Chk1, which potentially increases sensitivity to chemotherapeutic agents, resulting in decreased tumor growth (PMID: 18723486).
LY2603618 CHK1 Inhibitor 14 LY2603618 is a small molecule that inhibits CHK1, which may lead to disruption of DNA synthesis, early mitosis, and apoptosis, and may increase tumor cell sensitivity to chemotherapeutics (PMID: 24114124).
GDC-0575 ARRY-575|RG7741 CHK1 Inhibitor 14 GDC-0575 selectively inhibits CHK1, which potentially results in increased response to chemotherapeutic agents (PMID: 29162833).
CCT244747 SYN-1216 CHK1 Inhibitor 14 CCT244747 inhibits CHK1, potentially resulting in increased tumor cell death and increased sensitivity to other antitumor agents (PMID: 22929806, PMID: 27422809).
GDC-0425 RG7602 CHK1 Inhibitor 14 GDC-0425 is a selective CHK1 inhibitor, which may enhance chemosenstivity, potentially resulting in decreased tumor growth (PMID: 27815358).
SRA737 CCT245737 CHK1 Inhibitor 14 SRA737 (CCT245737) is a selective oral inhibitor of CHK1, which may enhance sensitivity of tumor cells to chemotherapeutics, thereby resulting in increased antitumor activity (PMID: 27167172).
LY2880070 ESP-01 CHK1 Inhibitor 14 LY2880070 selectively inhibits CHK1, which potentially results in increased response to chemotherapeutic agents (PMID: 28331049).
MK-8776 SCH900776 CHK1 Inhibitor 14 MK-8776 is a selective CHK1 inhibitor, which may enhance sensitivity of tumor cells to chemotherapeutic agents (PMID: 22203733).
CHIR-124 CHK1 Inhibitor 14 CHIR-124 is a selective inhibitor of CHK1, which may enhance sensitivity of tumor cells to chemotherapeutic agents (PMID: 17255282, PMID: 22244109).
Molecular Profile Protein Effect Treatment Approaches