Drug Class Detail

Drug Class CTNNB1 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
iCRT-3 CTNNB1 Inhibitor 26 iCRT-3 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling and results in apoptosis and inhibition of cell proliferation (PMID: 24188694).
RX-5902 CTNNB1 Inhibitor 26 RX-5902 binds to and inhibits Ddx5, which in turn inhibits beta-catenin signaling, results in down-regulation of gene expression and tumor cell growth inhibition (PMID: 25649741).
JW67 CTNNB1 Inhibitor 26 JW67 is a small molecule that inhibits canonical Wnt signaling, potentially resulting in decreased tumor cell growth (PMID: 21199802).
ICG-001 CTNNB1 Inhibitor 26 ICG-001 disrupts the interaction of CTNNB1 and c-AMP response element-binding protein, thereby preventing downstream CTNNB1 signaling to promote apoptosis (PMID: 15314234).
CCT036477 CTNNB1 Inhibitor 26 CCT036477 inhibits TCF/CTNNB1 dependent transcription thereby blocking Wnt signaling, which results in apoptosis (PMID: 20610623).
Pri-724 CTNNB1 Inhibitor 26 PRI-724 is a Wnt signaling pathway inhibitor which antagonistically inhibits the recruiting of beta-catenin with its coactivator CBP, thereby inhibiting tumor growth (NCI Drug Dictionary).
CCT031374 CTNNB1 Inhibitor 26 CCT031374 inhibits TCF/CTNNB1 dependent transcription thereby blocking Wnt signaling, which results in apoptosis (PMID: 20610623).
Niclosamide Niclocide CTNNB1 Inhibitor 26 Niclosamide inhibits Wnt signaling, potentially resulting in decreased tumor growth (PMID: 21531761).
iCRT-14 CTNNB1 Inhibitor 26 iCRT-14 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling and results in inhibition of cell proliferation (PMID: 24188694).
PKF115-584 CTNNB1 Inhibitor 26 PKF115-584 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling and promote apoptosis (PMID: 20360943).
BC21 CTNNB1 Inhibitor 26 BC21 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling, which can prevent cell proliferation and induce apoptosis (PMID: 22224445).
PKF118-310 CTNNB1 Inhibitor 26 KDM4 Inhibitor 2 PKF118-310 inhibits KDM4A activity (PMID: 27767379) and the CTNNB1/TCF interaction, which results in apoptosis and anti-tumor activity (PMID: 19662654).
FH535 CTNNB1 Inhibitor 26 FH535 is PPAR antagonist and Wnt/CTNNB1 pathway inhibitor, which prevents cell proliferation (PMID: 18347139).
JW74 CTNNB1 Inhibitor 26 JW74 is a small molecule that inhibits canonical Wnt signaling, potentially resulting in decreased tumor cell growth (PMID: 21199802).
NC043 CTNNB1 Inhibitor 26 NC043 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling resulting in apoptosis and interruption of the cell cycle (PMID: 21321609).
Pyrvinium CTNNB1 Inhibitor 26 Pyrvinium activates CK1-alpha, which leads to CTNNB1 degradation and inhibition of Wnt signaling thereby inducing apoptosis (PMID: 20890287).
LF3 CTNNB1 Inhibitor 26 LF3 is a small molecule that inhibits the interaction between Beta-catenin and TCF, resulting in reduced Wnt target gene expression, decreased migration of tumor cells, and potentially resulting in decreased tumor growth (PMID: 26645562).
PMED-1 CTNNB1 Inhibitor 26 PMED-1 inhibits Ctnnb1 and CBP interactions to decrease Wnt signalling thereby inhibiting cell proliferation (PMID: 24819961).
CCT070535 CTNNB1 Inhibitor 26 CCT070535 inhibits TCF/CTNNB1 dependent transcription thereby blocking Wnt signaling, which results in apoptosis (PMID: 20610623).
iCRT-5 CTNNB1 Inhibitor 26 iCRT-5 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling and results in inhibition of cell proliferation (PMID: 23155232).
StAx-35 CTNNB1 Inhibitor 26 StAx-35 inhibits CTNNB1/TCF4 mediated transcription, thereby decreasing downstream Wnt signaling to prevent cell proliferation (PMID: 23071338).
CWP232291 CTNNB1 Inhibitor 26 CWP23229 inhibits beta-catenin mediated transcriptional activity, which potentially leads to decreased tumor cell proliferation (PMID: 21317452).
BC2059 CTNNB1 Inhibitor 26 BC2059 binds to beta-catenin (CTNNB1) and interferes with binding to TBL1 and TBLR1, resulting in increased degradation of beta-catenin and potentially leading to increased apoptosis of tumor cells with activated canonical Wnt signaling (PMID: 28500235).
PNU-74654 CTNNB1 Inhibitor 26 PNU-74654 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling thereby preventing transcription of downstream target genes (PMID: 21565795).
CWP232228 CTNNB1 Inhibitor 26 CWP232228 is a small molecule that inhibits binding of Ctnnb1 to TCF, resulting in decreased Wnt signaling and inhibition of tumor growth (PMID: 25660951).
CGP049090 CTNNB1 Inhibitor 26 CGP049090 inhibits the interaction of CTNNB1 with TCF7L2 to block Wnt signaling and promote apoptosis (PMID: 20360943).
Molecular Profile Protein Effect Treatment Approaches
APC C1274fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1444* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC Y1376* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34E gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 T41A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 H36P gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC N1300fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1483fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K716* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1197* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1484fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1305fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 A21T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34V gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34R gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC E1464fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC N741fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1374* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC N1455fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1315* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1364fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1378fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1096* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1554fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R213* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1312* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1556fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1306fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 A13T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC E1408* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1301fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1318fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 E67K gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC E1317* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1451* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1470fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1513* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1291* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45F gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC R1450* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1345* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32G gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC K1310fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1443fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1547* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E763* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R640G loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC W553* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 V22A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC Q1303* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1294* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 P44_S45del gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC L684* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R216* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R232* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1465fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC E1295* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32V gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 P44A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37C gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC A1351fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1289fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1440fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1356fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1307fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1400* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1557fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1309Afs*3 loss of function CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1461* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 A39G gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC I1311fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1496fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC H1490fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1447* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC H1375fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1310* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45P gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC N1455Ifs*18 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Y737* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC A928fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1578fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1309fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1471fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1346* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1314fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1127* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L795Sfs*25 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1356* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1348fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1435fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R405* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1378* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 T41I gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC E1309* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1453fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1303fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E853* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Y935* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 E54K gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC N869fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1486fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1499* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1312fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1817fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35S gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC A952Qfs*10 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1379* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC C1387* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1462fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1480* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1411fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1497fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC F1491fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1429* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R499* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1488Ffs*26 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC M1431fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 W383R gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC Q1131* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1439fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1309Dfs*4 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32E gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G48D gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC G1416* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1465Wfs*3 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33C gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC R1114* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1485fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E658* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G1357fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1387fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1215* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 H36Y gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC A1402fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1544* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC G471* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1355fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC N1026S loss of function CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 act mut gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC T1438fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P950Afs*13 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I606fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1372fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1322* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33L gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC T1301Pfs*4 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Y1376fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1308* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32H gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G38P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC I1164fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1449fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1394fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1475fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1493fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1370* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1564* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C207* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1296fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32N gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC K1555* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1446fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1458fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q424* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC D1297fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R283* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1577* unknown CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC D1425fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1445fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S811* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R302* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC C1410* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1488* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 K335I gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A43P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC P1361fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1350* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45C gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC Q1406* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 N387K gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC P1373fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 W25_D32del gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC L1489fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1436fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37F gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC A1492fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1469* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC F1354fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 A43T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC S1278* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1464* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R876* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1397* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A39T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC R1399Ffs*9 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1554* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1495fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E190* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1316fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1353* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC R554* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1367* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC A1325fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33F gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC R564* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC R1435* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC T1459fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45del gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC Q1294fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S31fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC I1307Kfs*14 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1338* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC E1306* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q886* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC P1319fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC S1315fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC Q1067* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1552* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L665* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
APC D1422fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC V1377fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC K1555fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC L1488fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
APC inact mut loss of function CTNNB1 Inhibitor Tankyrase Inhibitor
APC E1494fs loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor