Drug Class Detail

Drug Class DNA_PK Inhibitor


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Drug Name Trade Name Synonyms Drug Classes Drug Description
MSC2490484A M3814|M-3814 DNA_PK Inhibitor 5 MSC2490484A is a DNA-dependent protein kinase (DNA-PK) inhibitor that blocks DNA damage repair, which may lead to antitumor activity (NCI Drug Dictionary).
NU7026 DNA_PK Inhibitor 5 NU7026 is an ATP-competitive inhibitor of DNA-PKcs, which may increase sensitivity of tumor cells to radiotherapy (PMID: 26716839, PMID: 16249792).
KU60648 KU-0060648 DNA_PK Inhibitor 5 KU60648 is a DNA protein kinase inhibitor, which may lead to impairment of double stranded break repair, thereby resulting in decreased cell viability (PMID: 28224663).
NU7441 DNA_PK Inhibitor 5 NU7441 inhibits DNA-PK, which may result in increased sensitivity of tumor cells to radiation and chemotherapy (PMID: 16707462).
Panulisib P7170 ALK Inhibitor 19 DNA_PK Inhibitor 5 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 Panulisib (P7170) inhibits Pi3k, mTOR, Alk, and DNA-PK, resulting in inhibition of cancer cell growth (PMID: 25466244).
Molecular Profile Protein Effect Treatment Approaches