Drug Class Detail

Drug Class DNMT inhibitor (Pan)


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Decitabine Dacogen 5-aza-2-deoxycytidine DNMT inhibitor (Pan) 5 Dacogen (decitabine) is cytidine analog that incorporates into DNA and forms covalent bonds with DNA methyltransferases (DNMTs), resulting in decreased DNMT activity and hypomethylation, and potentially leading to reduced tumor growth (PMID: 28159832, PMID: 25130173). Dacogen (decitabine) is FDA approved for use in patients with myelodysplastic syndromes (FDA.gov).
Zebularine 1-beta-D-ribofuranosyl-2(1H)-pyrimidinone DNMT inhibitor (Pan) 5 Zebularine is a cytidine analog that is incorporated into DNA and forms a complex with DNA methyltransferases, resulting in decreased DNA methylation and potentially leading to activation of silenced tumor suppressor genes and decreased tumor cell growth (PMID: 16239434, PMID: 15324698).
Guadecitabine S110|DNMT inhibitor SGI-110 DNMT inhibitor (Pan) 5 Guadecitabine (SGI-110) is a dinucleotide comprised of decitabine and deoxyguanosine, which inhibits DNA methylation, potentially resulting in decreased tumor cell growth (PMID: 20442312, PMID: 17616700).
SGI-1027 DNMT inhibitor (Pan) 5 SGI-1027 binds and inhibits DNMT1, DNMT3A, and DNMT3B, which leads to decreased DNA methylation and may result the activation of silenced tumor suppressor genes (PMID: 19417133).
Azacitidine Vidaza azacytidine|CC-486|5-azacytidine|5-AC|U-18496 DNMT inhibitor (Pan) 5 Vidaza (azacitidine) is a cytidine analog that incorporates into DNA and RNA and binds to DNA methyltransferases (DNMTs), resulting in DNMT degradation and decreased DNA methylation, and leading to increased tumor cell death (PMID: 28159832, PMID: 28067760). Vidaza (azacitidine) is FDA-approved for use in patients with some subtypes of myelodysplastic syndrome (FDA.gov).
Molecular Profile Protein Effect Treatment Approaches