Drug Class Detail

Drug Class EGFR Inhibitor 1st gen

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Erlotinib Tarceva CP358774 EGFR Inhibitor (Pan) 38 EGFR Inhibitor 1st gen 3 Tarceva (erlotinib) is a first-generation EGFR inhibitor, which is FDA approved for non-small cell lung carcinoma patients with EGFR exon 19 deletions and/or EGFR L858R and in combination with gemcitabine for patients with advanced pancreatic cancer (FDA.gov; PMID: 25302162).
Icotinib BPI-2009|Conmana EGFR Inhibitor 1st gen 3 Icotinib is a selective EGFR inhibitor that inhibits both wild-type and mutant forms of EGFR, which may result in decreased tumor cell proliferation (PMID: 22112293).
Gefitinib Iressa ZD1839 EGFR Inhibitor (Pan) 38 EGFR Inhibitor 1st gen 3 Iressa (gefitinib) is a first-generation EGFR inhibitor that binds EGFR and inhibits downstream signaling, potentially resulting in decreased growth of tumors with EGFR activation (PMID: 26980062, PMID: 25302162, PMID: 15284455). Iressa (gefitinib) is FDA approved for use in patients with non-small cell lung cancer harboring an EGFR exon 19 deletion or EGFR L858R (FDA.gov).
Molecular Profile Protein Effect Treatment Approaches