Drug Class Detail

Drug Class ERK Inhibitor (pan)


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Drug Name Trade Name Synonyms Drug Classes Drug Description
AEZS-131 ERK Inhibitor (pan) 13 AEZS-131 is an inhibitor of both Erk1 and Erk2, which may result in cell cycle arrest and inhibit tumor growth (Cancer Res April 15, 2011 71; 3563).
GDC-0994 ERK Inhibitor (pan) 13 GDC-0994 is a small molecule inhibitor of ERK1 and ERK2, which may decrease tumor growth (Cancer Res October 1, 2014 74:DDT02-03).
LY3214996 ERK Inhibitor (pan) 13 LY3214996 inhibits ERK1/2, potentially resulting in decreased growth of tumors with alterations in the RAS/MAPK pathway (AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4973).
ONC201 TIC-10|TIC10 Akt Inhibitor (Pan) 17 ERK Inhibitor (pan) 13 ONC201 (TIC-10) binds to the G-protein coupled receptor, DRD2, leading to inactivation of AKT and ERK, which relocates Foxo3a to the nucleus and then leads to tumor cell apoptosis mediated by (TNF)-related apoptosis-inducing ligand (TRAIL) signaling (PMID: 23390247).
MK-8353 SCH900353 ERK Inhibitor (pan) 13 MK-8353 is an analog of SCH772984, which targets both Erk1 and Erk2 and may inhibit cell growth (PMID: 25142146).
SCH772984 SCH984 ERK Inhibitor (pan) 13 SCH772984 is an ATP-competitive inhibitor of both ERK1 and ERK2, which may result in growth inhibition and tumor regression (PMID: 23614898).
Ulixertinib BVD-523 ERK Inhibitor (pan) 13 Ulixertinib (BVD-523) inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways and resulting in growth inhibition (PMID: 28939558).
VRT11E ERK Inhibitor (pan) 13 VRT11E is an inhibitor of Erk, which may result in decreased cell growth (PMID: 24265153).
VX-11e ERK Inhibitor (pan) 13 VX-11e is an ATP-competitive inhibitor of Mapk1 (Erk2) and Mapk3 (Erk1), which may result in growth inhibition and tumor regression (PMID: 17300186, PMID: 19827834).
LTT462 LTT 462 ERK Inhibitor (pan) 13 LTT462 inhibits ERK, resulting in decreased downstream signaling, and reduced ERK-dependent proliferation and survival of tumor cells (NCI Drug Dictionary).
DEL-22379 ERK Inhibitor (pan) 13 DEL-22379 inhibits ERK dimerization, resulting in decreased extranuclear ERK signaling and potentially leading to reduced growth of ERK pathway-driven tumors (PMID: 26267534).
CC-90003 ERK Inhibitor (pan) 13 CC-90003 inhibits ERK, which leads to decreased proliferation of ERK-dependent tumor cells and may be effective against KRAS-mutant tumors (PMID: 30275173).
KO-947 ERK Inhibitor (pan) 13 KO-947 is an inhibitor of both ERK 1 and 2, which results in inhibition of Erk signaling, thereby potentially blocking cell proliferation and inducing tumor regression (EJC Dec 2016, 69:1; S126).
Molecular Profile Protein Effect Treatment Approaches