Drug Class Detail

Drug Class FGFR Inhibitor (Pan)

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ODM-203 FGFR Inhibitor (Pan) 18 VEGFR Inhibitor (Pan) 30 ODM-203 inhibits FGFR and VEGFR family members, potentially resulting in decreased tumor cell proliferation and decreased tumor growth (PMID: 30301864).
Ponatinib Iclusig AP24534 BCR-ABL Inhibitor 23 DDR1 Inhibitor 8 DDR2 inhibitor 7 FGFR Inhibitor (Pan) 18 FLT3 Inhibitor 48 KIT Inhibitor 48 PDGFR-alpha Inhibitor 7 RET Inhibitor 36 SRC Inhibitor 26 VEGFR Inhibitor (Pan) 30 Iclusig (ponatinib) inhibits the Bcr-Abl fusion, and other tyrosine kinases, such as RET, DDR, VEGFR, FGFR, KIT, and FLT3 (PMID: 23526464, PMID: 25284748, PMID: 19878872). Iclusig (ponatinib) is FDA approved for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph positive ALL) as well as ABL1 T315I CML and ABL1 T315I Ph positive ALL (FDA.gov).
SSR128129E FGFR Inhibitor (Pan) 18 SSR128129E is an allosteric pan-FGFR inhibitor which may inhibit angiogenesis and tumor growth (PMID: 23597562, PMID: 24760775).
Dovitinib TKI258|CHIR-258 CSF1R Inhibitor 22 FGFR Inhibitor (Pan) 18 FLT3 Inhibitor 48 KIT Inhibitor 48 PDGFR Inhibitor (Pan) 27 VEGFR Inhibitor (Pan) 30 Dovitinib (TKI258) targets multiple receptor tyrosine kinases including Flt3, c-Kit, CSF1R, FGFR 1-4, VEGFR 1-3, and PDGFR alpha and beta, potentially resulting in decreased tumor growth (PMID: 15598814, PMID: 25219510, PMID: 23658459, PMID: 16033847).
Rogaratinib BAY 1163877|BAY-1163877|BAY1163877 FGFR Inhibitor (Pan) 18 Rogaratinib (BAY 1163877) is a small molecule pan-FGFR inhibitor, which reduces downstream signaling, potentially resulting in decreased tumor cell proliferation (PMID: 27429073, PMID: 29451369).
FIIN-1 FGFR Inhibitor (Pan) 18 FIIN-1 is an irreversible pan-FGFR inhibitor which blocks activation and downstream signaling and may inhibit transformation and proliferation in cancer cells (PMID: 20338520).
PRN1371 FGFR Inhibitor (Pan) 18 PRN1371 is an irreversible inhibitor of FGFR1-4 that blocks FGFR signaling, leading to apoptosis and tumor regression in animal models (Eu J Cancer 2014 Vol 50, Suppl 6:157).
TAS-120 FGFR Inhibitor (Pan) 18 TAS-120 is a pan-FGFR inhibitor, which result in the inhibition of FGFR-mediated signal transduction pathways and tumor cell proliferation (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 372PD).
HMPL-453 HMPL453|HMPL 453 FGFR Inhibitor (Pan) 18 HMPL-453 binds and inhibits FGFR -1, -2, and -3, which may result in the inhibition of FGFR mediated signal transduction pathways and inhibition of tumor cell proliferation (NCI Drug Dictionary).
Lenvatinib Lenvima E7080 FGFR Inhibitor (Pan) 18 KIT Inhibitor 48 PDGFR Inhibitor (Pan) 27 RET Inhibitor 36 VEGFR Inhibitor (Pan) 30 Lenvima (lenvatinib) inhibits VEGFR, FGFR, PDGFR, KIT, and RET, and suppresses cell proliferation and angiogenesis (PMID: 21781317, PMID: 25295214, PMID: 17943726). Lenvima (lenvatinib) is FDA approved for use in patients with radioactive iodine-refractory differentiated thyroid cancer, unresectable hepatocellular carcinoma, and in combination with Afinitor (everolimus) for renal cell carcinoma (FDA.gov).
ASP5878 FGFR Inhibitor (Pan) 18 ASP5878 is an inhibitor of FGFR1-4 that inhibits tumor cell proliferation (Mol Cancer Ther December 2015 14; A170).
BGJ398 Infigratinib FGFR Inhibitor (Pan) 18 Infigratinib (BGJ398) is pan-FGFR inhibitor, which inhibits tumor angiogenesis and tumor cell proliferation (NCI Drug Dictionary).
Erdafitinib JNJ-42756493 FGFR Inhibitor (Pan) 18 Erdafitinib (JNJ-42756493) selectively inhibits FGFR1-4, resulting in decreased downstream signaling, and potentially leading to reduced growth of tumors with activated FGFR signaling (PMID: 28341788).
Nintedanib Ofev BIBF 1120|Vargatef FGFR Inhibitor (Pan) 18 PDGFR Inhibitor (Pan) 27 RET Inhibitor 36 VEGFR Inhibitor (Pan) 30 Ofev (nintedanib) is a triple angiokinase inhibitor that acts by blocking VEGFR, FGFR, RET, and PDGFR, thereby preventing tumorigenesis (PMID: 24947258, PMID: 24561444). Ofev (nintedanib) is FDA approved for use in patients with idiopathic pulmonary fibrosis (FDA.gov).
AZ6089 AZ12576089 FGFR Inhibitor (Pan) 18 AZ6089 (AZ12576089) binds and inhibits FGFR1, 2, 3, and 4, which may result in the inhibition of FGFR mediated signal transduction pathways and inhibition of tumor cell proliferation (PMID: 22869148).
FIIN-2 FGFR Inhibitor (Pan) 18 FIIN-2 is a selective, irreversible Fgfr inhibitor that can inhibits Fgfr mutants that confer resistance to first-generation Fgfr inhibitors, resulting in growth inhibition in tumor cells (PMID: 25349422).
LY2874455 FGFR Inhibitor (Pan) 18 LY2874455, a pan-FGFR inhibitor, has equivalent potency against FGFR1-4 and inhibits FGF/FGFR mediated signaling to reduce tumor growth (PMID: 21900693).
MPT0L145 FGFR Inhibitor (Pan) 18 MPT0L145 is a dual FGFR and PIK3C3 inhibitor, which enhances autophagy and may result in increased tumor cell death (PMID: 29222162).
Molecular Profile Protein Effect Treatment Approaches
FGFR3 V788M gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G382R gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K650N gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R200C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR1 V561M gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 N546K gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR3 N540K gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 M536I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 S249C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 amp no effect FGFR Inhibitor (Pan) FGFR2 Antibody FGFR2 Inhibitor
FGFR2 N549K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 C228R gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 act mut gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L761Tfs*55 unknown FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 K650E gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 I548V gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 R669G gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 K650M gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 Y376C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2-CCDC6 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C383R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR1 K656E gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR2 L618M gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 D641G gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 S371C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 I538V gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 N550K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564F gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 V555M gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 Y375C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 N540S gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R669Q gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3-TACC3 gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor U0126
FGFR2 S267_D273dup gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 G372C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G380R gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 V564I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR1-TACC1 gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR2-BICC1 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3-BAIAP2L1 gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 V565I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 K652E gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 C342Y gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR1 amp no effect FGFR Inhibitor (Pan) FGFR1 Inhibitor GSK3052230
FGFR2 G663E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 G382D gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 over exp no effect FGFR Inhibitor (Pan) FGFR3 Antibody FGFR3 Inhibitor
FGFR2 E565G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 over exp no effect FGFR Inhibitor (Pan) FGFR2 Inhibitor GSK3052230
FGFR2 K659E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 Y647C gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 N549T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR1 P252S gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR2 K659N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W290_I291delinsC gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 D101Y gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K526E gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 D641N gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 V50I gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R248C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 G370C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 E565A gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K641R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2-AHCYL1 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K525E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 T341P gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 D786N gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 K641N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E566A gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E566G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R203C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 F276C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 Y375C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W290C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L617F gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M538I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 K650T gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR1 over exp no effect FGFR Inhibitor (Pan) FGFR1 Inhibitor GSK3052230
FGFR2 S252W gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor GSK3052230
FGFR1 act mut gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR2 - TACC3 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR1 T695A gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR3 Y373C gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR1 P252T gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR2 C382R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564L gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K660E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N550S gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 A391E gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 amp no effect FGFR Inhibitor (Pan) FGFR3 Antibody FGFR3 Inhibitor
FGFR3 K650Q gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 S372C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R678G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR3 act mut gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR3 R124W gain of function - predicted FGFR Inhibitor (Pan) FGFR3 Inhibitor
FGFR2 P253R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 N549H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K660N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor