Drug Class Detail

Drug Class Gamma secretase inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MK0752 MK-0752 Gamma secretase inhibitor 12 MK-0752 is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 20463236, PMID: 23340294).
YO-01027 Dibenzazepine Gamma secretase inhibitor 12 YO-01027 (dibenzazepine) is a dipeptidic gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 20064975).
LY900009 Gamma secretase inhibitor 12 LY900009 inhibits gamma secretase, resulting in decreased Notch signaling and potentially leading to reduced tumor growth (PMID: 26798966).
RO4929097 Gamma secretase inhibitor 12 RO4929097 is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 19773430).
PF-03084014 Nirogacestat Gamma secretase inhibitor 12 Nirogacestat (PF-03084014) is a small molecule that selectively binds and inhibits Gamma-secretase inhibiting its proteolytic activity on downstream targets including NOTCH receptor proteins thus blocking pathway activation in cancer (NCI Drug Dictionary).
LY411575 Gamma secretase inhibitor 12 LY411575 is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 14709552).
DAPT GSI-IX Gamma secretase inhibitor 12 DAPT (GSI-IX) is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 11145990).
MRK-003 Gamma secretase inhibitor 12 MRK-003 is a gamma-secretase inhibitor which inhibits Notch3 signaling and induces apoptosis in cancer cells (PMID: 17804716).
L-685458 L-685,458 Gamma secretase inhibitor 12 L-685458 is a small molecule which selectively binds and inhibits gamma-secretase inhibiting proteolytic cleavage of downstream targets including NOTCH receptor proteins thus blocking pathway activation in cancer (PMID: 10913280).
Semagacestat LY450139 Gamma secretase inhibitor 12 Semagacestat (LY450139) is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 22323718).
Avagacestat BMS-708163 Gamma secretase inhibitor 12 Avagacestat (BMS-708163) is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 24900185).
GSI-18 Gamma secretase inhibitor 12 GSI-18 is a small molecule compound that binds and inhibits Gamma-secretase inhibiting its activity on downstream targets including NOTCH signaling proteins thus blocking pathway activation in cancer (PMID: 15603957).
Molecular Profile Protein Effect Treatment Approaches
NOTCH1 S2467fs gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 A1552G gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 I1680S gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 R1627L gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 I1616N gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 Q2459* gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 amp no effect Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 L1593P gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 V1676D gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 R1683W gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 act mut gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 A1701P gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 A1552V gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 A1570G gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 L1596H gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 V1575A gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 F1592S gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 S2467* gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 H2428fs gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 V2443fs unknown Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 Q2440* gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 V1576E gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 R1598P gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 L1678P gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 A1707T gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 V1599M gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 P2475fs gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 L1600P gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 S2449fs gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 I1616T gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 I1718T gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 L1574P gain of function Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 V1676I gain of function - predicted Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor
NOTCH1 over exp no effect Gamma secretase inhibitor NOTCH Inhibitor (Pan) NOTCH1 Antibody NOTCH1 Inhibitor